10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 6 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Information
Calcium D-Panthotenate (D-Pantothenic Acid Calcium), also called vitamin B5 Calcium, is a water-soluble vitamin and an essential nutrient for many animals.
In vitro
Pantothenic\xa0acid\xa0increases mainly the content of free\xa0glutathione, with little effect on protein-boundglutathione in human lymphoblastoic (Jurkat) cells.\xa0Pantothenic\xa0acid also increases\xa0cell\xa0respiration with pyruvate as the exogenous substrate. Pantothenic\xa0acid belongs to vitamin B group and is the building stone of coenzyme A. Pantothenic\xa0acid can be therefore infer that its beneficial effect in various kinds of cell damage by ROS is related to the increased content or stimulated biosynthesis of this coenzyme. Pantothenic\xa0acid increases the glutathione content by more than 50% and increases the GSH/GSSG ratio by approximately the same factor. Pantothenic\xa0acid\xa0and N-acetylcysteine alleviates the\xa0ultraviolet-induced decrease of glutathione content, diminished lipid peroxidation, and partly protects the\xa0cells\xa0against\xa0apoptosisproduced by\xa0ultraviolet\xa0irradiation.
In vivo
Pantothenic acid-treated rats exhibited higher basal levels of corticosterone and progesterone than control rats in Adrenal cells. The response of ACTH and/or PRL on corticosterone and progesterone release is higher in the pantothenic acid-treated rats than in the control rats. Pantothenic acid supplementation stimulates the ability of adrenal cells in male rats to secrete corticosterone and progesterone. Pantothenic acid supplementation induces adrenalhyperresponsiveness to ACTH stimulation, and PRL further stimulated adrenal sensitivity to ACTH. Pantothenic acid prior to valproic acid (VPA) significantly protects against VPA-induced neural tube defects (NTDs) in CD-1mice. Pantothenic acid prevents VPA-induced alterations in NF-kappaB, Pim-1, and c-Myb in CD-1 mice.
Cell Data
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Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →| Rotação específica [α] | 27 ° (C=5, H2O) |
|---|---|
| Ponto de fusão (°C) | 195-196°C |
