Carbimazole - 10mM in DMSO , Thyroid peroxidase inhibitor, CAS No.22232-54-8, Thyroid peroxidase inhibitor

CAS: 22232-54-8 Cat. No.: C408083 Fórmula: C₇H₁₀N₂O₂S Peso molecular: 186.23 Número CE: 244-854-4

GRADE & PURITY 10mM in DMSO

Synonyms

1H-Imidazole-1-carboxylic acid, 2,3-dihydro-3-methyl-2-thioxo-, ethyl ester

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Visão geral

Information

Carbimazole is an imidazole antithyroid agent.
In vitro

Carbimazole is an effective thyroid hormone inhibitor under a class of drugs known as pro-drugs. It is considered a pro-drug because it converts to methimazole after being absorbed by the body, generating an antithyroid action that works against hyperthyroidism (excessive production of thyroid hormones) and thyrotoxicosis (inflammation of the thyroid gland). Methimazole prevents the thyroid peroxidase enzyme from coupling and iodinating the tyrosine residues on thyroglobulin, hence reducing the production of the thyroid hormones T3 and T4 (thyroxine).

In vivo

Cell Data

cell lines：Human breast cancer cells MDA-MB-231

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Sinónimos

1H-Imidazole-1-carboxylic acid, 2,3-dihydro-3-methyl-2-thioxo-, ethyl ester

Especificações e pureza

10mM in DMSO

Mecanismos bioquímicos e fisiológicos

Carbimazole is an imidazole antithyroid agent.

Condições de armazenamento de armazenamento

Store at -80°C

Enviado em

Dry ice packs + Cold packs

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Tipo de ação

INHIBITOR

Mecanismo de ação

Thyroid peroxidase inhibitor

Propriedades do produto

• ALogP: 0.7

Nomes e identificadores

• SMILES isoméricas: CCOC(=O)N1C=CN(C1=S)C
• WGK Alemanha: 3
• Peso molecular: 186.23
• Reaxy-Rn: 144339
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=144339&ln=

Propriedades químicas e físicas

• Ponto de fusão (°C): 124 °C

Referências

1. Nian Liu, Shuchao Zhang, Yiliang Liu, Xing Lu, Xiaozhen He.  (2025)  Potential Mechanisms Underlying Carbimazole-Induced Cardiotoxicity and Hepatotoxicity in Zebrafish.  JOURNAL OF APPLIED TOXICOLOGY,      [PMID:40784728] [10.1002/jat.4889]