Carboplatina - Moligand™, ≥99,95% base de metais , CAS No.41575-94-4

CAS: 41575-94-4 Cat. No.: C295384 Fórmula: C₆H₁₂N₂O₄Pt Peso molecular: 371.25 Número CE: 255-446-0

GRADE & PURITY Moligand™, ≥99.95% metals basis

Synonyms

AB01273939-01 | EN300-123065 | NSC758182 | NSC-758182 | STL451040 | Tox21_112586_1 | Carboplatina | DTXCID201476080 | Impureza I da amicacina, Norma de Referência da Farmacopeia Europeia (EP) | Pharmakon1600-01502106 | SCHEMBL4964 | Lopac0_000230 | NSC201

Storage

Armazenar a 2-8°C, protegido da luz

Shipped In

Gelo húmido

Visão geral

Pensa-se que a carboplatina forma aductos de ADN inter e intratrilhos que activam vias de sinalização que culminam em apoptose. O desenvolvimento da carboplatina foi inspirado na eficácia do seu progenitor, a cisplatina (sc-200896), o primeiro desta classe de agentes antineoplásicos. A ação deste grupo de compostos à base de platina é atribuída principalmente à formação de adutos de ADN, mas estas moléculas também se ligam a outras moléculas biológicas, incluindo enzimas, que podem desempenhar um papel no seu mecanismo de ação.
Um agente antitumoral que se liga ao ADN levando à apoptose

Classe de produtos
hAPIs, hAPIs de base metálica

Propriedades químicas

Fórmula química

C6H12N2O4Pt

Fórmula empírica

[Pt(NH3)2(cbdc)]

Massa molecular

371.25

Metal

Pt

Teor teórico de metal

53

Estado físico

pó

Cor
Pureza do metal

branco

99.95

Specifications

Sinónimos

AB01273939-01 | EN300-123065 | NSC758182 | NSC-758182 | STL451040 | Tox21_112586_1 | Carboplatina | DTXCID201476080 | Impureza I da amicacina, Norma de Referência da Farmacopeia Europeia (EP) | Pharmakon1600-01502106 | SCHEMBL4964 | Lopac0_000230 | NSC201

Especificações e pureza

Moligand™, ≥99,95% base de metais

Mecanismos bioquímicos e fisiológicos

A carboplatina danifica o ADN através da formação de ligações cruzadas intratrilho com resíduos de guanina vizinhos. Os tumores adquirem resistência a estes fármacos através da perda da atividade de reparação da incompatibilidade do ADN (MMR) e da consequ

Informações legais

Produto da Umicore

Condições de armazenamento de armazenamento

Armazenar a 2-8°C, protegido da luz

Enviado em

Gelo húmido

Grau

Moligand™

Pureza

≥99.95% metals basis

Nomes e identificadores

Pubchem Sid

504758672

Pubchem Sid Url

https://pubchem.ncbi.nlm.nih.gov/substance/504758672

Sorrisos canónicos

C1CC(C1)(C(=O)O)C(=O)O.[NH2-].[NH2-].[Pt+2]

IUPAC Name

azanide;cyclobutane-1,1-dicarboxylic acid;platinum(2+)

InChIKey

VSRXQHXAPYXROS-UHFFFAOYSA-N

INCHI

1S/C6H8O4.2H2N.Pt/c7-4(8)6(5(9)10)2-1-3-6;;;/h1-3H2,(H,7,8)(H,9,10);2*1H2;/q;2*-1;+2

SMILES isoméricas

C1CC(C1)(C(=O)O)C(=O)O.[NH2-].[NH2-].[Pt+2]

WGK Alemanha

3

RTECS

TP2300000

CAS alternativo

41575-94-4

Número NSC

201345

Termos de entrada MeSH

Blastocarb;Carboplat;Carboplatin;Carbosin;Carbotec;CBDCA;cis-Diammine(cyclobutanedicarboxylato)platinum II;Ercar;JM 8;JM-8;JM8;Nealorin;Neocarbo;NSC 241240;NSC-241240;NSC241240;Paraplatin;Paraplatine;Platinwas;Ribocarbo

Peso molecular

371.25

Reaxy-Rn

25079300

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=25079300&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic acids and derivatives
    • Classe Carboxylic acids and derivatives
      • Subclass Dicarboxylic acids and derivatives

• Kingdom: Organic compounds
• Superclass: Organic acids and derivatives
• Classe: Carboxylic acids and derivatives
• Subclass: Dicarboxylic acids and derivatives
• Intermediate Tree Nodes: Not available
• Direct Parent: Dicarboxylic acids and derivatives
• Alternative Parents: Organic transition metal salts Carboxylic acids Organic oxides Organic nitrogen compounds Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aliphatic homomonocyclic compounds
• Substituents: Dicarboxylic acid or derivatives - Organic transition metal salt - Carboxylic acid - Organic nitrogen compound - Organic oxygen compound - Organic oxide - Hydrocarbon derivative - Organic salt - Organooxygen compound - Carbonyl group - Aliphatic homomonocyclic compound
• Descrição: This compound belongs to the class of organic compounds known as dicarboxylic acids and derivatives. These are organic compounds containing exactly two carboxylic acid groups.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Propriedades químicas e físicas

• Solubilidade: Soluble in water.
• Sensibilidade: Light sensitive.
• Ponto de fusão (°C): >275℃
• Peso molecular: 371.250 g/mol
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 0
• Exact Mass: 371.045 Da
• Monoisotopic Mass: 371.045 Da
• Topological Polar Surface Area: 76.600 Ų
• Heavy Atom Count: 13
• Formal Charge: 0
• Complexity: 177.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 4

XLogP3

Perguntas frequentes

What does the trace-metals specification mean?

This product is specified at ≥99.95% on a trace-metals basis. That figure describes metallic impurity content rather than overall chemical assay, so it is the relevant specification for ICP-MS, semiconductor and battery applications. Lot-specific values are stated on the Certificate of Analysis.

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How should this product be stored?

Store at 2–8 °C, protected from light. The material is light-sensitive — keep it in its original opaque or amber container.

How is this product shipped?

This product ships chilled on wet ice. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 41575-94-4, the molecular formula is C6H12N2O4Pt, and the molecular weight is 371.25 g/mol. InChIKey VSRXQHXAPYXROS-UHFFFAOYSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.