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· · COA & SDS Disponível para todos os produtos · Envio no mesmo dia em itens em estoque CB-5083 - ≥98% , CAS No.1542705-92-9
Disponível para encomenda
Synonyms
1H-Indole-4-carboxamide, 1-(7,8-dihydro-4-((phenylmethyl)amino)-5H-pyrano(4,3-d)pyrimidin-2-yl)-2-methyl- | AS-55872 | BC177445 | NCGC00481317-01 | NCGC00481317-03 | 1542705-92-9 | AC-29018 | CB 5083 | HMS3873E13 | JDP | 1-[4-(benzylamino)-7,8-dihydro-5H-
Shipped In
Ice chest + Ice pads
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Why this grade ≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
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Quality documents SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof Cited in 1 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Visão geral In vitro
In A549 cells, CB-5083 causes significant K48 poly-ubiquitinated protein and CHOP accumulation as well as p62 reduction, and kills tumor cells with IC50 of 680 nM.
Specifications Sinónimos
1H-Indole-4-carboxamide, 1-(7,8-dihydro-4-((phenylmethyl)amino)-5H-pyrano(4,3-d)pyrimidin-2-yl)-2-methyl- | AS-55872 | BC177445 | NCGC00481317-01 | NCGC00481317-03 | 1542705-92-9 | AC-29018 | CB 5083 | HMS3873E13 | JDP | 1-[4-(benzylamino)-7,8-dihydro-5H-
Especificações e pureza
≥98%
Mecanismos bioquímicos e fisiológicos
CB-5083 is a potent, selective, and orally bioavailable p97 AAA ATPase inhibitor with IC50 of 11 nM. Phase 1.
Condições de armazenamento de armazenamento
Store at -20°C
Enviado em
Ice chest + Ice pads
Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.
Propriedades do produto ALogP 3.748 hba_count 4 Contagem HBD 2 Ligação rotativa 5
Nomes e identificadores Pubchem Sid 504772314 Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/504772314 Sorrisos canónicos CC1=CC2=C(C=CC=C2N1C3=NC4=C(COCC4)C(=N3)NCC5=CC=CC=C5)C(=O)N IUPAC Name 1-[4-(benzylamino)-7,8-dihydro-5H-pyrano[4,3-d]pyrimidin-2-yl]-2-methylindole-4-carboxamide InChIKey RDALZZCKQFLGJP-UHFFFAOYSA-N INCHI 1S/C24H23N5O2/c1-15-12-18-17(22(25)30)8-5-9-21(18)29(15)24-27-20-10-11-31-14-19(20)23(28-24)26-13-16-6-3-2-4-7-16/h2-9,12H,10-11,13-14H2,1H3,(H2,25,30)(H,26,27,28) SMILES isoméricas CC1=CC2=C(C=CC=C2N1C3=NC4=C(COCC4)C(=N3)NCC5=CC=CC=C5)C(=O)N Peso molecular 413.47 Reaxy-Rn 26539278 Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=26539278&ln=
Documentation 📋 Safety Data Sheet (SDS) Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS → ✅ Certificate of Analysis (COA) Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA → 📊 Datasheet Quick-reference summary of product specifications and applications.
View datasheet → 🔬 Specification Sheet Full quality attributes and acceptance criteria for this grade.
View spec sheet →
Advanced Data Taxonomic Classification Kingdom Organic compounds Superclass Organoheterocyclic compounds Classe Indoles and derivatives Subclass Indolecarboxylic acids and derivatives Intermediate Tree Nodes Not available Direct Parent Indolecarboxamides and derivatives Alternative Parents Pyranopyridines Pyranopyrimidines Indoles Benzylamines Aminopyrimidines and derivatives Substituted pyrroles Imidolactams Pyridines and derivatives Heteroaromatic compounds Primary carboxylic acid amides Oxacyclic compounds Dialkyl ethers Azacyclic compounds Organic oxides Amines Hydrocarbon derivatives Molecular Framework Aromatic heteropolycyclic compounds Substituents Indolecarboxamide derivative - Pyranopyridine - Pyranopyrimidine - Indole - Benzylamine - Aminopyrimidine - Monocyclic benzene moiety - Pyridine - Pyrimidine - Substituted pyrrole - Benzenoid - Imidolactam - Pyrrole - Heteroaromatic compound - Carboxamide group - Primary carboxylic acid amide - Azacycle - Oxacycle - Carboxylic acid derivative - Dialkyl ether - Ether - Amine - Organic oxygen compound - Organic nitrogen compound - Organic oxide - Hydrocarbon derivative - Organonitrogen compound - Organooxygen compound - Aromatic heteropolycyclic compound Descrição This compound belongs to the class of organic compounds known as indolecarboxamides and derivatives. These are compounds containing a carboxamide group attached to an indole. External Descriptors Not available Data sources 1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
Estrutura 3D Alvos associados (humanos) Alvos associados (não humanos) Mecanismos de ação Certificados（CoA,COO,BSE/TSE e Mapa de Análise) Propriedades químicas e físicas Solubilidade Solubility (25°C) In vitro DMSO: 82 mg/mL (198.32 mM); Ethanol: 29 mg/mL warmed with 50ºC Water: bath (70.13 mM); Water: Insoluble; DMSO (mg/mL) Solubilidade máxima 82 DMSO (mM) Solubilidade máxima 198.3215227 Água (mg/mL) Solubilidade máxima ＜1 Peso molecular 413.500 g/mol XLogP3 3.100 Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 5 Rotatable Bond Count 5 Exact Mass 413.185 Da Monoisotopic Mass 413.185 Da Topological Polar Surface Area 95.100 Ų Heavy Atom Count 31 Formal Charge 0 Complexity 627.000 Isotope Atom Count 0 Defined Atom Stereocenter Count 0 Undefined Atom Stereocenter Count 0 Defined Bond Stereocenter Count 0 Undefined Bond Stereocenter Count 0 The total count of all stereochemical bonds 0 Covalently-Bonded Unit Count 1
FAQs e artigos Citations of This Product Referências 1. Jiajian Wang, Yongnan Su, Lanqing Zhang, Hanchuan Mou, Wei Wu, Yunxin Xia, Fei Yu, Fan Yang, Jihong Zhang. (2026) Buxus alkaloid KBA01 targets Valosin-containing protein to inhibit colorectal cancer progression via the p53-Wnt/β-catenin axis. PHYTOMEDICINE, [PMID:42208104 ] [10.1016/j.phymed.2026.158314 ]
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