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Início
Por alvo / caminho / doença
Por vias de sinalização
Enzima metabólica/protease
Fosfoglicerato desidrogenase (PHGDH)
CBR 5884 - 10mM in DMSO , CAS No.681159-27-3

CBR 5884 - 10mM in DMSO , CAS No.681159-27-3

Name: CBR 5884 - 10mM in DMSO , CAS No.681159-27-3
SKU: C425422
Availability: InStock

CAS: 681159-27-3 Cat. No.: C425422 Fórmula: C₁₄H₁₂N₂O₄S₂ Peso molecular: 336.39 Número CE: 100-774-0

COA

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CBR 5884 - 10mM in DMSO CAS No(681159-27-3) by Aladdin Scientific

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Disponível para encomenda

GRADE & PURITY 10mM in DMSO

Synonyms

Ethyl 5-[(2-furanylcarbonyl)amino]-3-methyl-4-thiocyanato-2-thiophenecarboxylate

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Visão geral Specifications Nomes e identificadores Documentation Advanced Data Estrutura 3D Mecanismos de ação Certificados（CoA,COO,BSE/TSE e Mapa de Análise) Propriedades químicas e físicas Calculadoras de soluções Revisões

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Why this grade

10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

🌡

Storage & shipping

Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.

📋

Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

📚

Literature proof

Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Visão geral

Application：

CBR-5884 has been used as a 3-phosphoglycerate dehydrogenase (PHGDH) inhibitor to explore the role of PHGDH in Müller cells from different retinal regions and also used in trypan blue exclusion assay to determine the number of viable MYCN cells.

Specifications

Sinónimos

Ethyl 5-[(2-furanylcarbonyl)amino]-3-methyl-4-thiocyanato-2-thiophenecarboxylate

Especificações e pureza

10mM in DMSO

Mecanismos bioquímicos e fisiológicos

Phosphoglycerate dehydrogenase (PHGDH) inhibitor (IC50= 33μM). Decreasesde novoserine synthesis in cancer cells. Inhibits proliferation of cancer cell lines having high PHGDH expression levels.

Condições de armazenamento de armazenamento

Store at -80°C

Enviado em

Dry ice packs + Cold packs

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Nomes e identificadores

Pubchem Sid	528763677
Sorrisos canónicos	CCOC(=O)C1=C(C(=C(S1)NC(=O)C2=CC=CO2)SC#N)C
IUPAC Name	ethyl 5-(furan-2-carbonylamino)-3-methyl-4-thiocyanatothiophene-2-carboxylate
InChIKey	QBVIRPJBDIZKBC-UHFFFAOYSA-N
INCHI	1S/C14H12N2O4S2/c1-3-19-14(18)11-8(2)10(21-7-15)13(22-11)16-12(17)9-5-4-6-20-9/h4-6H,3H2,1-2H3,(H,16,17)
SMILES isoméricas	CCOC(=O)C1=C(C(=C(S1)NC(=O)C2=CC=CO2)SC#N)C
Peso molecular	336.39
Reaxy-Rn	29216596
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=29216596&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Estrutura 3D

Mecanismos de ação

Certificados（CoA,COO,BSE/TSE e Mapa de Análise)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Propriedades químicas e físicas

Peso molecular	336.400 g/mol
XLogP3	3.600
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	6
Exact Mass	336.024 Da
Monoisotopic Mass	336.024 Da
Topological Polar Surface Area	146.000 Å²
Heavy Atom Count	22
Formal Charge	0
Complexity	479.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

Calculadoras de soluções

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Revisões

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