CCG258208 hydrochloride - ≥98% , CAS No.C659401

CAS: C659401 Cat. No.: C659401 Fórmula: C₂₄H₂₆ClFN₄O₄ Peso molecular: 488.94

GRADE & PURITY ≥98%

Storage

Store at 2-8°C,Desiccated

Shipped In

Wet ice

Visão geral

CCG258208 (GRK2-IN-1) hydrochloride is a potent and selective GRK2 ( G protein-coupled receptor kinase 2 ) inhibitor ( IC 50 =30 nM) while maintaining 230-fold selectivity over GRK5 ( IC 50 =7.09 μM) and more than 2500-fold selectivity over GRK1 ( IC 50 =

Appearance:Solid

IC50& Target:GRK2 30 nM (IC 50 ) GRK5 7.1 μM (IC 50 )

In Vitro:CCG258208 (Compound 14as) (0-1 μM; 10 min) shows significant improvement in βAR-stimulated contractility in mouse cardiomyocytes. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability Assay

In Vivo:CCG258208 (Compound 14as) (intraperitoneal injection; 10mg/kg; once) treatment shows superior half-life in vivo . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: CD-1 mice Dosage: 10 m

Biological Activity:CCG258208 (GRK2-IN-1) hydrochloride is a potent and selective GRK2 ( G protein-coupled receptor kinase 2 ) inhibitor ( IC 50 =30 nM) while maintaining 230-fold selectivity over GRK5 ( IC 50 =7.09 μM) and more than 2500-fold selectivity over GRK1 ( IC 50 =

Specifications

Especificações e pureza

≥98%

Condições de armazenamento de armazenamento

Store at 2-8°C,Desiccated

Enviado em

Wet ice

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Pureza

≥98%

Nomes e identificadores

Sorrisos canónicos

FC1=C(C(NCC2=NNC=C2)=O)C=C([C@H]3[C@H](COC4=CC=C(OCO5)C5=C4)CNCC3)C=C1.[H]Cl

Peso molecular

488.94

Propriedades químicas e físicas

• Solubilidade: DMSO : 250 mg/mL (511.31 mM; Need ultrasonic) H2O : 50 mg/mL (102.26 mM; Need ultrasonic)