CDK8-IN-1 - 10mM in DMSO , CAS No.1629633-48-2

CAS: 1629633-48-2 Cat. No.: C655866 Fórmula: C₁₁H₈F₃N₃O Peso molecular: 255.20 PubChem CID: 86274989

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Visão geral

CDK8-IN-1 is a potent and selective CDK8 inhibitor with an IC 50 of 3 nM.

In Vivo

CDK8-IN-1 displays low systemic clearance, very good exposure and oral bioavailability. The t max is 0.25 h by PO. The mean values of C max are 9940 μg/L, 12740 μg/L by IV and PO respectively. The values of AUC are 9378, 25952 by IV and PO respectively . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:CDK8 3 nM (IC 50 )

Specifications

Especificações e pureza

10mM in DMSO

Mecanismos bioquímicos e fisiológicos

CDK8-IN-1 is a potent and selective CDK8 inhibitor with an IC 50 of 3 nM.

Condições de armazenamento de armazenamento

Store at -80°C

Enviado em

Dry ice packs + Cold packs

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Tipo de ação

INHIBITOR

Nomes e identificadores

• SMILES isoméricas: C1=CN=CC=C1C2=CNC(=C2C(F)(F)F)C(=O)N
• PubChem CID: 86274989
• Peso molecular: 255.20