Cholic acid - ≥98% , CAS No.81-25-4

CAS: 81-25-4 Cat. No.: C103690 Molecular Weight: 408.57 Beilstein Registry Number: 2822009 EC Number: 201-337-8
AVAILABLE TO ORDER
GRADE & PURITY ≥98%
Synonyms
5b-Cholic acid | 5beta-Cholan-24-oic acid, 3alpha,7alpha,12alpha-trihydroxy- | cholicacid | cholic-acid | MFCD00003672 | (4R)-4-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-trihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cycl
Storage
Room temperature
Shipped In
Normal
 ·  off list, applied to all prices below.
Size
Status
Price
Qty
5g
C103690-5g
1
$9.90
25g
C103690-25g
3
$29.90
100g
C103690-100g
3
$65.90
250g
C103690-250g
3
$139.90
500g
C103690-500g
2
$249.90
Enter a quantity for the sizes you want to add.
🧪

Why this grade

≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

🌡

Storage & shipping

Room temperature Ships Normal Check lot-specific COA for exact specifications.

📋

Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

📚

Literature proof

Cited in 53 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Overview

Non-denaturing ionic detergent used for extraction of membrane proteins.

Specifications

Synonyms
5b-Cholic acid | 5beta-Cholan-24-oic acid, 3alpha, 7alpha, 12alpha-trihydroxy- | cholicacid | cholic-acid | MFCD00003672 | (4R)-4-[(3R, 5S, 7R, 8R, 9S, 10S, 12S, 13R, 14S, 17R)-3, 7, 12-trihydroxy-10, 13-dimethyl-2, 3, 4, 5, 6, 7, 8, 9, 11, 12, 14, 15, 16, 17-tetradecahydro-1H-cycl
Specifications & Purity
≥98%
Biochemical and Physiological Mechanisms
Non-denaturing ionic detergent used for extraction of membrane proteins. Major primary bile acid produced in the liver and usually conjugated with glycine or taurine to form bile salts. Facilitates fat absorption and cholesterol excretion.
Storage
Room temperature
Shipped In
Normal
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Purity
≥98%
Names and Identifiers
Canonical SmilesCC(CCC(=O)O)C1CCC2C1(C(CC3C2C(CC4C3(CCC(C4)O)C)O)O)C
IUPAC Name(4R)-4-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-trihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid
InChIKeyBHQCQFFYRZLCQQ-OELDTZBJSA-N
INCHI1S/C24H40O5/c1-13(4-7-21(28)29)16-5-6-17-22-18(12-20(27)24(16,17)3)23(2)9-8-15(25)10-14(23)11-19(22)26/h13-20,22,25-27H,4-12H2,1-3H3,(H,28,29)/t13-,14+,15-,16-,17+,18+,19-,20+,22+,23+,24-/m1/s1
Isomeric SMILES C[C@H](CCC(=O)O)[C@H]1CC[C@@H]2[C@@]1([C@H](C[C@H]3[C@H]2[C@@H](C[C@H]4[C@@]3(CC[C@H](C4)O)C)O)O)C
WGK Germany 2
RTECS FZ9350000
Molecular Weight 408.57
Beilstein 2822009
Reaxy-Rn 2822005
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2822005&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassLipids and lipid-like molecules
ClassSteroids and steroid derivatives
SubclassBile acids, alcohols and derivatives
Intermediate Tree Nodes Hydroxy bile acids, alcohols and derivatives
Direct ParentTrihydroxy bile acids, alcohols and derivatives
Alternative Parents 7-hydroxysteroids  3-alpha-hydroxysteroids  12-hydroxysteroids  Secondary alcohols  Cyclic alcohols and derivatives  Polyols  Monocarboxylic acids and derivatives  Carboxylic acids  Organic oxides  Hydrocarbon derivatives  Carbonyl compounds  
Molecular FrameworkAliphatic homopolycyclic compounds
Substituents Trihydroxy bile acid, alcohol, or derivatives - 3-hydroxysteroid - 12-hydroxysteroid - 7-hydroxysteroid - 3-alpha-hydroxysteroid - Hydroxysteroid - Cyclic alcohol - Secondary alcohol - Carboxylic acid derivative - Carboxylic acid - Polyol - Monocarboxylic acid or derivatives - Organic oxide - Alcohol - Organic oxygen compound - Hydrocarbon derivative - Carbonyl group - Organooxygen compound - Aliphatic homopolycyclic compound
DescriptionThis compound belongs to the class of organic compounds known as trihydroxy bile acids, alcohols and derivatives. These are prenol lipids structurally characterized by a bile acid or alcohol which bears three hydroxyl groups.
External Descriptors C24 bile acids, alcohols, and derivatives
3D Structure
Interactive Chemical Structure Model





Associated Targets(Human)
GPBAR1 Tchem G-protein coupled bile acid receptor 1 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
PDE5A Tclin Phosphodiesterase 5A (5113 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ABL1 Tclin Tyrosine-protein kinase ABL (18331 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
EGFR Tclin Epidermal growth factor receptor erbB1 (33727 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
F2 Tclin Thrombin (11687 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CA2 Tclin Carbonic anhydrase II (17698 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ESR1 Tclin Estrogen receptor alpha (17718 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HMGCR Tclin HMG-CoA reductase (2475 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NR3C1 Tclin Glucocorticoid receptor (14987 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
INSR Tclin Insulin receptor (5558 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PGR Tclin Progesterone receptor (8562 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRB2 Tclin Beta-2 adrenergic receptor (11824 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CHRM2 Tclin Muscarinic acetylcholine receptor M2 (10671 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRB1 Tclin Beta-1 adrenergic receptor (6630 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR1A Tclin Serotonin 1a (5-HT1a) receptor (14969 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRA2A Tclin Alpha-2a adrenergic receptor (9450 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
AR Tclin Androgen Receptor (11781 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CHRM1 Tclin Muscarinic acetylcholine receptor M1 (12690 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
VDR Tclin Vitamin D receptor (26531 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ACE Tclin Angiotensin-converting enzyme (1423 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DRD2 Tclin Dopamine D2 receptor (23596 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MAOA Tclin Monoamine oxidase A (11911 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CNR1 Tclin Cannabinoid CB1 receptor (20913 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DRD1 Tclin Dopamine D1 receptor (9720 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DRD4 Tchem Dopamine D4 receptor (7907 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ACHE Tclin Acetylcholinesterase (18204 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PTGS1 Tclin Cyclooxygenase-1 (9233 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC6A2 Tclin Norepinephrine transporter (10102 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HRH2 Tclin Histamine H2 receptor (5428 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRA1D Tclin Alpha-1d adrenergic receptor (4171 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR1B Tclin Serotonin 1b (5-HT1b) receptor (2801 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR2A Tclin Serotonin 2a (5-HT2a) receptor (14758 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR2C Tclin Serotonin 2c (5-HT2c) receptor (11471 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADORA1 Tclin Adenosine A1 receptor (17603 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CALCR Tclin Calcitonin receptor (2215 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC6A4 Tclin Serotonin transporter (12625 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRA1A Tclin Alpha-1a adrenergic receptor (8359 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PTGS2 Tclin Cyclooxygenase-2 (13999 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HRH1 Tclin Histamine H1 receptor (7573 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRA1B Tclin Alpha-1b adrenergic receptor (2912 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
OPRM1 Tclin Mu opioid receptor (19785 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DRD3 Tclin Dopamine D3 receptor (14368 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
AVPR1A Tclin Vasopressin V1a receptor (5412 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
OPRD1 Tclin Delta opioid receptor (15096 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
OPRK1 Tclin Kappa opioid receptor (16155 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC6A3 Tclin Dopamine transporter (10535 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KCNH2 Tclin HERG (29587 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR4 Tclin Serotonin 4 (5-HT4) receptor (2068 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PDE3A Tclin Phosphodiesterase 3A (3309 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ESR2 Tclin Estrogen receptor beta (9272 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYSLTR1 Tclin Cysteinyl leukotriene receptor 1 (2118 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Associated Targets(non-human)
PLA2G1B Phospholipase A2 group 1B (227 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Agtr2 Angiotensin II type 2 (AT-2) receptor (803 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mc4r Melanocortin receptor 4 (1205 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Ltc4s Leukotriene C4 synthase (1 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Sigmar1 Sigma opioid receptor (160 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Npy1r Neuropeptide Y receptor type 1 (8 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Cruzipain (33337 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Cckar Cholecystokinin A receptor (90 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Nos2 Nitric oxide synthase, inducible (3573 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mapk1 MAP kinase ERK2 (650 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mmp9 Matrix metalloproteinase 9 (38 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Fgfr3 Fibroblast growth factor receptor 3 (21 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Pseudomonas aeruginosa (123386 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Staphylococcus aureus (210822 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Klebsiella aerogenes (4963 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Escherichia coli (133304 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mycobacterium tuberculosis (203094 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Enterococcus faecalis (29875 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Priestia megaterium (1154 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Yarrowia lipolytica (267 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Trypanosoma brucei brucei (13300 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Plasmodium falciparum (966862 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Cryptococcus neoformans (21258 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Candida albicans (78123 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Fusarium oxysporum (3998 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Oryctolagus cuniculus (11301 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Rattus norvegicus (775804 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Human immunodeficiency virus 1 (70413 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Benjaminiella poitrasii (79 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Danio rerio (3092 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Glra2 Glycine receptor (1745 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SARS-CoV-2 (38078 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mechanisms of Action
Certificates(CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

31 results found

Lot NumberCertificate TypeDateItem
I2209293Certificate of AnalysisJun 11, 2026 C103690
I2209294Certificate of AnalysisJun 11, 2026 C103690
B2624046Certificate of AnalysisJan 31, 2026 C103690
B2624047Certificate of AnalysisJan 31, 2026 C103690
B2624048Certificate of AnalysisJan 31, 2026 C103690
B2624049Certificate of AnalysisJan 31, 2026 C103690
C2201445Certificate of AnalysisDec 22, 2025 C103690
C2201444Certificate of AnalysisDec 22, 2025 C103690
G2503055Certificate of AnalysisJul 14, 2025 C103690
I2102095Certificate of AnalysisJun 09, 2025 C103690
A2607093Certificate of AnalysisDec 27, 2024 C103690
A2521099Certificate of AnalysisDec 27, 2024 C103690
A2521089Certificate of AnalysisDec 27, 2024 C103690
I2523077Certificate of AnalysisDec 27, 2024 C103690
A2521096Certificate of AnalysisDec 27, 2024 C103690
A2521095Certificate of AnalysisDec 27, 2024 C103690
I2403278Certificate of AnalysisAug 17, 2024 C103690
I2403277Certificate of AnalysisAug 17, 2024 C103690
L2412439Certificate of AnalysisAug 05, 2024 C103690
F2503145Certificate of AnalysisJul 05, 2024 C103690
F2503144Certificate of AnalysisJul 05, 2024 C103690
H2414036Certificate of AnalysisJul 23, 2022 C103690
I2209295Certificate of AnalysisJul 23, 2022 C103690
I2209296Certificate of AnalysisJul 23, 2022 C103690
I2209306Certificate of AnalysisJul 23, 2022 C103690
C2414070Certificate of AnalysisJul 23, 2022 C103690
G2218015Certificate of AnalysisJan 24, 2022 C103690
I2320097Certificate of AnalysisJan 24, 2022 C103690
F23051284Certificate of AnalysisJan 24, 2022 C103690
C2201447Certificate of AnalysisJan 24, 2022 C103690
C2201446Certificate of AnalysisJan 24, 2022 C103690

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Chemical and Physical Properties
SolubilitySoluble in alcohols, acetone, DMSO, methanol, and water (slightly).
SensitivityMoisture sensitive.
Melt Point(°C)197-202°C
Molecular Weight408.600 g/mol
XLogP33.600
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Exact Mass408.288 Da
Monoisotopic Mass408.288 Da
Topological Polar Surface Area98.000 Ų
Heavy Atom Count29
Formal Charge0
Complexity637.000
Isotope Atom Count0
Defined Atom Stereocenter Count11
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count1
Documents & Articles
Citations of This Product
References
1. Baofei Yan, Xian Zheng, Yun Wang, Jingwen Yang, Xingyu Zhu, Mengmeng Qiu, Kexin Xia, Yongan Wang, Mian Li, Sipan Li, Xinai Ma, Jianjun Xie, Fengtao Li, Tingming Fu, Wei Li.  (2023)  Liposome-Based Silibinin for Mitigating Nonalcoholic Fatty Liver Disease: Dual Effects via Parenteral and Intestinal Routes.  ACS Pharmacology & Translational Science,      [PMID:38093834] [10.1021/acsptsci.3c00210]
2. Wei Jia, Jiying Zhu.  (2023)  Molecular Mechanism of ε-Polylysine Treatment of Animal-Derived Foods: Glycine Amidinotransferase Activity Implicates Upregulation of l-Arginine and Creatine.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,      [PMID:37793042] [10.1021/acs.jafc.3c04033]
3. Dong Guo, Simin Chen, Weiguang Zhang, Jun Fan.  (2023)  Enantioselective effects of paclobutrazol and its enantiomers on glycolipid metabolism in zebrafish (Danio rerio).  PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY,      [PMID:37532357] [10.1016/j.pestbp.2023.105499]
4. Yin-Yi Ding, Yuxiang Pan, Wanyue Zhang, Yijing Sheng, Yanyun Cao, Zhenyu Gu, Qing Shen, Qingcheng Wang, Xi Chen.  (2022)  Preparation of Gum Arabic–Maltose–Pea Protein Isolate Complexes for 1−Octacosanol Microcapsule: Improved Storage Stability, Sustained Release in the Gastrointestinal Tract, and Its Effect on the Lipid Metabolism of High−Fat−Diet−Induced Obesity Mice.  Foods,  12  (1): (112).  [PMID:36613328] [10.3390/foods12010112]
5. Jiating Zheng, Xiaoru Peng, Taifeng Zhu, Shuyao Huang, Chao Chen, Guosheng Chen, Shuqin Liu, Gangfeng Ouyang.  (2022)  Detection of bile acids in small volume human bile samples via an amino metal-organic framework composite based solid-phase microextraction probe.  JOURNAL OF CHROMATOGRAPHY A,      [PMID:36345074] [10.1016/j.chroma.2022.463634]
6. Wei Xu, Yingying Kong, Tuo Zhang, Zhihua Gong, Wenjun Xiao.  (2022)  L-Theanine regulates lipid metabolism by modulating gut microbiota and bile acid metabolism.  JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE,  103  (3): (1283-1293).  [PMID:36087337] [10.1002/jsfa.12222]
7. Ma Wen, Yang Bingxin, Li Jun, Liu Mingxia, Li Xianjiang, Liu Huwei.  (2022)  Maltose-functional metal–organic framework assisted laser desorption/ionization mass spectrometry for small biomolecule determination.  MICROCHIMICA ACTA,  189  (7): (1-8).  [PMID:35689150] [10.1007/s00604-022-05338-x]
8. Xiaoxu Cheng, Zifeng Pi, Zhong Zheng, Shu Liu, Fengrui Song, Zhiqiang Liu.  (2022)  Combined 16S rRNA gene sequencing and metabolomics to investigate the protective effects of Wu-tou decoction on rheumatoid arthritis in rats.  JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,      [PMID:35447521] [10.1016/j.jchromb.2022.123249]
9. Ding Shen, Wei Hu, Suqing Zhao, Chuanbin Mao.  (2021)  Rapid Naked-Eye Detection of a Liver Disease Biomarker by Discovering Its Monoclonal Antibody to Functionalize Engineered Red-Colored Bacteria Probes.  ACS Omega,      [PMID:34870023] [10.1021/acsomega.1c04779]
10. Cui Xiping, He Qiyi, Yang Huiyi, Chen Yingshan, Shen Ding, Eremin Sergei A., Mu Yunping, Zhao Suqing.  (2021)  Development of enzyme-free single-step immunoassays for glycocholic acid based on palladium nanoparticle-mediated signal generation.  ANALYTICAL AND BIOANALYTICAL CHEMISTRY,  413  (23): (5733-5742).  [PMID:34476526] [10.1007/s00216-021-03548-5]
11. Jinxiu Lyu, Haijuan Li, Dengyang Yin, Meng Zhao, Qiang Sun, Mengzhe Guo.  (2021)  Analysis of eight bile acids in urine of gastric cancer patients based on covalent organic framework enrichment coupled with liquid chromatography-tandem mass spectrometry.  JOURNAL OF CHROMATOGRAPHY A,      [PMID:34348207] [10.1016/j.chroma.2021.462422]
12. Min Wen, Yubei Liu, Ruiying Chen, Ping He, Feihua Wu, Rui Li, Yining Lin.  (2021)  Geniposide suppresses liver injury in a mouse model of DDC-induced sclerosing cholangitis.  PHYTOTHERAPY RESEARCH,  35  (7): (3799-3811).  [PMID:33763888] [10.1002/ptr.7086]
13. Xiaoyu Lu, Hangyi Wu, Yiping Liang, Zhenhai Zhang, HuiXia Lv.  (2021)  Redox-responsive prodrug for improving oral bioavailability of paclitaxel through bile acid transporter-mediated pathway.  INTERNATIONAL JOURNAL OF PHARMACEUTICS,      [PMID:33746013] [10.1016/j.ijpharm.2021.120496]
14. Tao Gong, Rina Cheng, Xiaoyu Wang, Jing Li, Wenting Liang, Zhihong Wei, Shaomin Shuang, Yuyao Wang, Rui Guo.  (2021)  Supramolecular-interaction-mediated aggregation of anticarcinogens on triformyl cholic acid-functionalized Fe3O4 nanoparticles and their dual-targeting treatment for liver cancer.  NEW JOURNAL OF CHEMISTRY,  45  (15): (6880-6888).  [PMID:] [10.1039/D1NJ00248A]
15. Yufei Sun, Zhiqiang Liu, Zifeng Pi, Fengrui Song, Jianlin Wu, Shu Liu.  (2021)  Poria cocos could ameliorate cognitive dysfunction in APP/PS1 mice by restoring imbalance of Aβ production and clearance and gut microbiota dysbiosis.  PHYTOTHERAPY RESEARCH,  35  (5): (2678-2690).  [PMID:33432644] [10.1002/ptr.7014]
16. Chaochao Wen, Rina Cheng, Tao Gong, Yu Huang, Dan Li, Xuhua Zhao, Baofeng Yu, Dan Su, Zhiling Song, Wenting Liang.  (2020)  β-Cyclodextrin-cholic acid-hyaluronic acid polymer coated Fe3O4-graphene oxide nanohybrids as local chemo-photothermal synergistic agents for enhanced liver tumor therapy.  COLLOIDS AND SURFACES B-BIOINTERFACES,      [PMID:33341438] [10.1016/j.colsurfb.2020.111510]
17. Chao Liu, Kaiyu Zhang, Qinxing Sun, Weina Li.  (2020)  Bile acid-terpyridine conjugates: Steroidal skeleton controlled AIE effect and metal-tunable fluorescence and supramolecular assembly properties.  TETRAHEDRON,      [PMID:] [10.1016/j.tet.2020.131283]
18. Ma Chongyang, Wang Xueqian, Xu Tian, Zhang Shuang, Liu Shuling, Zhai Changming, Wang Zisong, Mu Jie, Li Changxiang, Cheng Fafeng, Wang Qingguo.  (2020)  An Integrative Pharmacology-Based Analysis of Refined Qingkailing Injection Against Cerebral Ischemic Stroke: A Novel Combination of Baicalin, Geniposide, Cholic Acid, and Hyodeoxycholic Acid.  Frontiers in Pharmacology,      [PMID:32457601] [10.3389/fphar.2020.00519]
19. Qiyi He, Huiyi Yang, Yingshan Chen, Ding Shen, Xiping Cui, Chunguo Zhang, Huanxin Xiao, Sergei A. Eremin, Yanxiong Fang, Suqing Zhao.  (2020)  Prussian blue nanoparticles with peroxidase-mimicking properties in a dual immunoassays for glycocholic acid.  JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,      [PMID:32416340] [10.1016/j.jpba.2020.113317]
20. Xia Lu, Zhefeng Fan.  (2019)  Determination of cholic acid in body fluids by β‑cyclodextrin-modified N-doped carbon dot fluorescent probes.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,      [PMID:30921656] [10.1016/j.saa.2019.03.066]
21. Jingjie Feng, Weiqiu Wen, Yong-Guang Jia, Sa Liu, Jianwei Guo.  (2019)  pH-Responsive Micelles Assembled by Three-Armed Degradable Block Copolymers with a Cholic Acid Core for Drug Controlled-Release.  Polymers,  11  (3): (511).  [PMID:30960495] [10.3390/polym11030511]
22. Sinan Wang, Wenxiao Dong, Li Liu, Mengque Xu, Yu Wang, Tianyu Liu, Yujie Zhang, Bangmao Wang, Hailong Cao.  (2019)  Interplay between bile acids and the gut microbiota promotes intestinal carcinogenesis.  MOLECULAR CARCINOGENESIS,  58  (7): (1155-1167).  [PMID:30828892] [10.1002/mc.22999]
23. Peng Xinwen, Xiang Zhihua, Du Fan, Tan Jiewen, Zhong Linxin, Sun Runcang.  (2017)  Amphiphilic xylan–cholic acid conjugates: synthesis and self-assembly behaviors in aqueous solution.  CELLULOSE,  25  (1): (245-257).  [PMID:] [10.1007/s10570-017-1595-0]
24. Ding Shen, Jie Zheng, Xiping Cui, Yingshan Chen, Qiyi He, Rui Lv, Zhaoxia Li, Suqing Zhao.  (2017)  Analysis of cholyglycine acid as a biomarker for the early diagnosis of liver disease by fluorescence polarization immunoassay.  SENSORS AND ACTUATORS B-CHEMICAL,      [PMID:] [10.1016/j.snb.2017.10.013]
25. Pan Chen, Dongshun Li, Yixin Chen, Jiahong Sun, Kaili Fu, Lihuan Guan, Huizhen Zhang, Yiming Jiang, Xi Li, Xuezhen Zeng, Xiao Chen, Min Huang, Huichang Bi.  (2017)  p53-mediated regulation of bile acid disposition attenuates cholic acid-induced cholestasis in mice.  BRITISH JOURNAL OF PHARMACOLOGY,  174  (23): (4345-4361).  [PMID:28910492] [10.1111/bph.14035]
26. Xueke Liu, Peng Wang, Chang Liu, Yiran Liang, Zhiqiang Zhou, Donghui Liu.  (2017)  Absorption, Distribution, Metabolism, and in Vitro Digestion of Beta-Cypermethrin in Laying Hens.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,      [PMID:28793773] [10.1021/acs.jafc.7b02581]
27. Ting Yang, Bangbang Wei, Jing Liu, Xinxin Si, Lulu Wang, Chunming Jiang.  (2024)  A landscape of metabolic variation among clinical outcomes of peritoneal dialysis in end-stage renal disease.  CLINICA CHIMICA ACTA,      [PMID:38342423] [10.1016/j.cca.2024.117826]
28. Shun Zhang, Ting Cai, Jing Lin, Jia-Juan Liu, Yong-Gang Zhao, Min-Yi Cao.  (2024)  Analysis of 15 bile acids in human plasma based on C18 functionalized magnetic organic polymer nanocomposite coupled with liquid chromatography-tandem mass spectrometry.  JOURNAL OF CHROMATOGRAPHY A,      [PMID:38704923] [10.1016/j.chroma.2024.464962]
29. Xiaohua Xu, Yongzhi Xu, Shengqiang Liang.  (2024)  Analytical Interference in Chemiluminescence Assay–Measured Angiotensin I, Angiotensin II, Aldosterone, and Renin.  JOURNAL OF CLINICAL LABORATORY ANALYSIS,  38  (10): (e25045).  [PMID:38822626] [10.1002/jcla.25045]
30. Hao Zhi, Zhongyan Wang, Xinyue Zhu, Wenhan Wu, Lu Yang, Yidong Dai, Zehua Wang, Ling Jiang, Yongmei Tan, Xiaodong Liu, Li Liu.  (2025)  Chronic liver injury decreases levels of cerebral carnitine and acetylcarnitine in rats partly due to the downregulation of OCTs and OCTN2 at the blood-brain barrier.  DRUG METABOLISM AND DISPOSITION,      [PMID:40300306] [10.1016/j.dmd.2025.100072]
31. Xinye Shi, Yuandi Xue, Yuxin Tu, Canrong Chen, Yajing Zhang, Zian Lin, Zongwei Cai.  (2024)  Covalent organic framework-based solid phase microextraction coupled with electrospray ionization mass spectrometry for the quantitative assessment of abnormal bile acids by triclosan exposure in mice.  TALANTA,      [PMID:39700720] [10.1016/j.talanta.2024.127398]
32. Xing Ren, Xiaojie Lu, Fan Wang, Jia Xu, Yueyuan Tan, Aiping Feng.  (2024)  Effects of dietary primary bile acids on the growth, intestinal morphology, gene expression, serum metabolites and intestinal microbiota in pearl gentian grouper fed a high lipid diet.  AQUACULTURE,      [PMID:] [10.1016/j.aquaculture.2024.741679]
33. Miao Zheng, Qi Su, Haoqing Wu, Chenggang Cai, Le Thanh Ninh, Haiying Cai.  (2024)  Elucidating Bile Acid Tolerance in Saccharomyces cerevisiae: Effects on Sterol Biosynthesis and Transport Protein Expression.  Foods,  13  (21): (3405).  [PMID:39517189] [10.3390/foods13213405]
34. Qingsheng Wang, Wen Huang, Qian Sun, Mengqi Le, Lili Cai, Yong-Guang Jia.  (2025)  Facially amphiphilic skeleton-derived antibacterial crown ether/silver ion complexes.  Soft Matter,      [PMID:39989433] [10.1039/D4SM01192A]
35. Qian Fang, Xiaoying Hou, Limei Fan, Yufei Deng, Xiaoxuan Li, Hongyun Zhang, Haiping Wang, Zhengqi Fu, Binlian Sun, Xiji Shu, Hongzhi Du, Yuchen Liu.  (2025)  Gut microbiota derived DCA enhances FOLFOX efficacy via Ugt1a6b mediated enterohepatic circulation in colon cancer.  PHARMACOLOGICAL RESEARCH,      [PMID:39894186] [10.1016/j.phrs.2025.107636]
36. Qin Kaili, Zhao Yingzhu, Zhang Yuqi, Zhu Huirui, Chang Bingmei, Zhai Xiang, Wang Xiaoyu, Gong Tao, Guo Rui.  (2024)  Methotrexate and triformyl cholic acid functionalized magnetic graphene oxide nanocomposite for multi-targeting chemo-photothermal therapy of hepatocellular carcinoma.  JOURNAL OF MATERIALS SCIENCE,      [PMID:] [10.1007/s10853-024-09965-y]
37. Wen Ma, Mingxia Liu, Mengling Tu, Gang Wang, Jun Li, Fen Liu, Jian Yang, Xianjiang Li.  (2024)  Novel multi-layered MXene as laser desorption ionization mass spectrometry matrix for rapid detection of small biomolecules.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2024.157466]
38. Sheng Chang, Qiang Yang, Jiahuan Liu, Li Yin, Jihong Han, Lanlan Zong, Xiaohui Pu.  (2024)  The Increased Dissolution and Oral Absorption of Itraconazole by Nanocrystals with an Endogenous Small-Molecule Surfactant as a Stabilizer.  MOLECULES,  29  (8): (1769).  [PMID:38675589] [10.3390/molecules29081769]
39. Yong Ding, Xi Luo, Jiasheng Guo, Baiying Xing, Haoyu Lin, Haohan Ma, Yicun Wang, Meng Li, Chuan Ye, Sen Yan, Kangjie Lin, Jinxin Zhang, Yingying Zhuo, Qixing Nie, Donghui Yang, Zhipeng Zhang, Yanli Pang, Kai Wang, Ming Ma, Luhua Lai, Changtao Jiang.  (2025)  Identification of gut microbial bile acid metabolic enzymes via an AI-assisted pipeline.  CELL,      [PMID:40780197] [10.1016/j.cell.2025.07.017]
40. Yilin Huang, Xingli Huo, Huijun Liu, Danni Li, Zongning Yin.  (2025)  Bile acids and polyphenols inhibit succinic anhydride-induced protein succinylation and amyloid aggregation: Mechanistic insights.  ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS,      [PMID:40854493] [10.1016/j.abb.2025.110601]
41. Lei Tang, Yinan Feng, Yifei Bian, Zhixiong Sun, Qiaoce Ding, Dongying Chen, Jian-Rong Wang, Xuefeng Mei.  (2025)  Bile Acid-based Microcapsule-Like Cocrystals of Phytosterols with Enhanced Solubility, Bioavailability, and Bioactivity.  MOLECULAR PHARMACEUTICS,      [PMID:40923148] [10.1021/acs.molpharmaceut.5c00851]
42. Jun Lin, Qixing Nie, Jie Cheng, Ya-Ni Zhong, Tianyao Zhang, Xiuying Zhang, Xiaoyan Ge, Yong Ding, Canyang Niu, Yuhua Gao, Kai Wang, Mingxin Gao, Xuemei Wang, Weixuan Chen, Chuyu Yun, Chuan Ye, Jinkun Xu, Weike Shaoyong, Lijun Zhang, Pan Shang, Xi Luo, Zhiwei Zhang, Xin Zheng, Xueying Sha, Jinxin Zhang, Shaoping Nie, Xuguang Zhang, Fazheng Ren, Huiying Liu, Erdan Dong, Xiao Yu, Linong Ji, Yanli Pang, Jin-Peng Sun, Changtao Jiang.  (2025)  A microbial amino-acid-conjugated bile acid, tryptophan-cholic acid, improves glucose homeostasis via the orphan receptor MRGPRE.  CELL,      [PMID:40446798] [10.1016/j.cell.2025.05.010]
43. Shuai Xue, Jianli Yin, Jiawei Shao, Yuanhuan Yu, Linfeng Yang, Yidan Wang, Mingqi Xie, Martin Fussenegger, Haifeng Ye.  (2017)  A Synthetic-Biology-Inspired Therapeutic Strategy for Targeting and Treating Hepatogenous Diabetes.  MOLECULAR THERAPY,      [PMID:28153094] [10.1016/j.ymthe.2016.11.008]
44. Yijie Wang, Ruolan Feng, Meijuan Shi, Huirui Zhu, Moxuan Zhao, Jinyu Li, Hongqin Wang, Xiaoning Li, Tao Gong, Rui Guo.  (2025)  Composites of graphene oxide and gold Nanospheres: A dual-targeted Recognition and dual-responsive release Chemophotothermal therapeutic platform.  ADVANCED POWDER TECHNOLOGY,      [PMID:] [10.1016/j.apt.2025.104874]
45. Yangzu Gao, Haoyu Li, Qian Wu, Bang Chen, Kangzhen Xu, Cong Li, Yehua Shen.  (2025)  Functions of Pugionium cornutum (L.) Gaertn Extracts: Investigating the Mechanism of Gastroparesis Amelioration from the Perspective of the Gut Microbiota and Its Metabolites.  Foods,  14  (16): (2800).  [PMID:40870711] [10.3390/foods14162800]
46. Jia Xu, Fajun Jiang, Yichao Li, Ermeng Yu, Shiwei Xie, Junxiang Lai, Fan Wang.  (2025)  A comparison of effects of glycocholic acid, taurocholic acid, and cholic acid on liver health in pearl gentian grouper (Epinephelus fuscoguttatus♂ × E. lanceolatus♀) fed a high-lipid diet.  Aquaculture Reports,      [PMID:] [10.1016/j.aqrep.2025.103185]
47. Zhiye Yan, Weiwei Tang, Bin Li.  (2025)  Expanding Metabolome Coverage in LC–MS/MS Analysis through Hydralazine-Based Multifunctional Derivatization.  ANALYTICAL CHEMISTRY,      [PMID:41277254] [10.1021/acs.analchem.5c02101]
48. Yunpeng Gao, Ran Chen, Kaojin Wang, Caihong Lin, Weimin Xiao, Qian Sun, Yukang Liu, Meng Zhang, Lin Wang, Yong-Guang Jia, Xiaoxia Zhu.  (2026)  Integration of Bile Acid-Based Facial Amphiphilicity and Lysine Chirality for Eradicating Drug-Resistant Bacteria.  Small,      [PMID:41607134] [10.1002/smll.202514941]
49. Ya Wang, Yuan Wang, Yan Sun, Xianbin Sun, Yuanming Li, Haijun Chen, Yu Gao.  (2026)  Ultrathin Oleanolic Acid/Perfluorocarbon-Ferrocene Nanosheets Trigger Reactive Species Storm to Reshape Tumor Microenvironment for Enhanced Chemodynamic Therapy.  ACS Nano,      [PMID:41740023] [10.1021/acsnano.5c20827]
50. Linghao Zhao, Wei Yang, Shengjin Cui, Jingang Luo, Yaxin Cao, Nan Yan, Hongying Wang.  (2026)  Interference Assessment for High-Performance Liquid Chromatography HbA1c Assays.  BIOMEDICAL CHROMATOGRAPHY,  40  (3): (e70382).  [PMID:41631984] [10.1002/bmc.70382]
51. Hongyu Jiang, Wenyan Xiong, Yingna Feng, Xingjie Li, Jinzhuo Tan, Zongde Zhang.  (2026)  Bile acids enrichment fuel tumor aerobic glycolysis and immune evasion via stabilizing FXR-RARα.  Frontiers in Immunology,      [PMID:] [10.3389/fimmu.2026.1750358]
52. Fan Wang, Fajun Jiang, Jia Xu, Yixin Liang, Xujia Liu, Yichao Li, Junlian Zhuang, Fangjuan Huang, Fu Lei, Chuhang Chen, Ermeng Yu, Junxiang Lai.  (2026)  Conjugated Bile Acids Enhance Growth Performance, Liver Health, and Bile Acid Metabolism in Pearl Gentian Grouper Fed a High Plant-Protein Diet.  AQUACULTURE NUTRITION,  2026  (1): (1857237).  [PMID:] [10.1155/anu/1857237]
53. Danhua Zhu, Qingmiao Shi, Xiaoxi Ouyang, Yanhong Zhang, Xiaopeng Yu, Long Yang, Kunkai Su, Lanjuan Li.  (2026)  Integrative transcriptomic and metabolomic analyses of puerarin against cholestatic liver fibrosis.  Current Molecular Pharmacology,      [PMID:] [10.1016/j.cmp.2026.04.003]
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