CL 075 - Moligand™, ≥98%(HPLC) , Agonist of TLR8, CAS No.256922-53-9, Agonist of TLR8

CAS: 256922-53-9 Cat. No.: C288075 Fórmula: C₁₃H₁₃N₃S Peso molecular: 243.33

GRADE & PURITY Moligand™, ≥98%(HPLC)

Synonyms

2-PROPYL-[1,3]THIAZOLO[4,5-C]QUINOLIN-4-AMINE | 2-Propyl[1,3]thiazolo[4,5-C]quinolin-4-Amine | 2-propylthiazolo[4,5-c]quinolin-4-amine | 2-propylthiazolo[4,5-c]quinolin4-amine | BDBM50398245 | EX-A5490 | CL 075 | 3M-002 | CL075 | CL-075 | HY-117066 | AS-3

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Specifications

Sinónimos

2-PROPYL-[1,3]THIAZOLO[4,5-C]QUINOLIN-4-AMINE | 2-Propyl[1,3]thiazolo[4,5-C]quinolin-4-Amine | 2-propylthiazolo[4,5-c]quinolin-4-amine | 2-propylthiazolo[4,5-c]quinolin4-amine | BDBM50398245 | EX-A5490 | CL 075 | 3M-002 | CL075 | CL-075 | HY-117066 | AS-3

Especificações e pureza

Moligand™, ≥98%(HPLC)

Mecanismos bioquímicos e fisiológicos

TLR8 agonist. Induces production of TNF-α and IL-12 from peripheral blood mononuclear cells (PBMCs). Promotes maturation of monocyte-derived dendritic cells in combination withPoly(I:C).

Condições de armazenamento de armazenamento

Store at -20°C

Enviado em

Ice chest + Ice pads

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Grau

Moligand™

Tipo de ação

AGONIST

Mecanismo de ação

Agonist of TLR8

Pureza

≥98%(HPLC)

Nomes e identificadores

• Sorrisos canónicos: CCCC1=NC2=C(S1)C3=CC=CC=C3N=C2N
• IUPAC Name: 2-propyl-[1,3]thiazolo[4,5-c]quinolin-4-amine
• InChIKey: NFYMGJSUKCDVJR-UHFFFAOYSA-N
• INCHI: 1S/C13H13N3S/c1-2-5-10-16-11-12(17-10)8-6-3-4-7-9(8)15-13(11)14/h3-4,6-7H,2,5H2,1H3,(H2,14,15)
• SMILES isoméricas: CCCC1=NC2=C(S1)C3=CC=CC=C3N=C2N
• CAS alternativo: 256922-53-9
• Termos de entrada MeSH: CL 075;CL-075;CL075 cpd
• Peso molecular: 243.33
• Reaxy-Rn: 11322027
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=11322027&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Classe Quinolines and derivatives
      • Subclass Aminoquinolines and derivatives

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Classe: Quinolines and derivatives
• Subclass: Aminoquinolines and derivatives
• Intermediate Tree Nodes: Not available
• Direct Parent: Aminoquinolines and derivatives
• Alternative Parents: Aminopyridines and derivatives Imidolactams Benzenoids Thiazoles Heteroaromatic compounds Azacyclic compounds Primary amines Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Aminoquinoline - Aminopyridine - Imidolactam - Benzenoid - Pyridine - Heteroaromatic compound - Thiazole - Azole - Azacycle - Organic nitrogen compound - Hydrocarbon derivative - Primary amine - Organonitrogen compound - Amine - Aromatic heteropolycyclic compound
• Descrição: This compound belongs to the class of organic compounds known as aminoquinolines and derivatives. These are organic compounds containing an amino group attached to a quinoline ring system.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Alvos associados (humanos)

TLR8 Tchem Toll-like receptor 8 (1 Activities)

Discover Target: TLR8

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PBMC (10003 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TLR8 Tchem Toll-like receptor 8 (1853 Activities)

Discover Target: TLR8

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Alvos associados (não humanos)

Human immunodeficiency virus 1 (70413 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Hepatitis C virus (23859 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Tlr7 Toll-like receptor 7 (174 Activities)

Discover Target: Tlr7

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mecanismos de ação

Propriedades químicas e físicas

• Solubilidade: Solvent:DMSO, Max Conc. mg/mL: 12.17, Max Conc. mM: 50; Solvent:ethanol, Max Conc. mg/mL: 2.43, Max Conc. mM: 10
• Peso molecular: 243.330 g/mol
• XLogP3: 3.500
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 243.083 Da
• Monoisotopic Mass: 243.083 Da
• Topological Polar Surface Area: 80.000 Ų
• Heavy Atom Count: 17
• Formal Charge: 0
• Complexity: 273.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Referências

1. Pingfeng Fu, Xiaofeng Lin, Gen Li, Zihao Chen, Hua Peng.  (2018)  Degradation of Thiol Collectors Using Ozone at a Low Dosage: Kinetics, Mineralization, Ozone Utilization, and Changes of Biodegradability and Water Quality Parameters.  Minerals,  8  (11): (477).  [PMID:] [10.3390/min8110477]

Perguntas frequentes

What is the purity of this product, and how is it determined?

This product is supplied at ≥98% purity, determined by HPLC. Lot-specific values are stated on the Certificate of Analysis.

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 256922-53-9, the molecular formula is C??H??N?S, and the molecular weight is 243.33 g/mol. InChIKey NFYMGJSUKCDVJR-UHFFFAOYSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.