CMS-121 - 10mM in DMSO , CAS No.1353224-53-9

CAS: 1353224-53-9 Cat. No.: C654537 Fórmula: C₂₀H₁₉NO₃ Peso molecular: 321.37 PubChem CID: 135741221

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Visão geral

CMS-121 is a quinolone derivative and an orally active acetyl-CoA carboxylase 1 (ACC1) inhibitor. CMS-121 protects HT22 cells against ischemia and oxidative damage with EC 50 values of 7 nM and 200 nM, respectively. CMS-121 has strong neuroprotective, anti-inflammatory, antioxidative and renoprotective activities

In Vitro

CMS-121 (1 µM; 4 hours; HT22 cells) treatment increases the phosphorylation of ACC1 at serine 79. CMS-121 can increase acetyl-CoA in cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: HT22 cells Concentration: 1 µM Incubation Time: 4 hours Result: Increases the phosphorylation of ACC1 at serine 79.

In Vivo

CMS-121 (~20 mg/kg; oral administration; daily; for 4 months; female SAMP8 mice) treatment reduces cognitive decline as well as metabolic and transcriptional markers of aging in the brain when administered to rapidly aging SAMP8 mice. CMS-121 preserves mitochondrial homeostasis by regulating acetyl-coenzyme A (acetyl-CoA) metabolism . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Female SAMP8 mice (9 months old) Dosage: ~20 mg/kg/day Administration: Oral administration; daily; for 4 months Result: Reduced cognitive decline as well as metabolic and transcriptional markers of aging in the brain.

IC50& Target:Acetyl-CoA carboxylase 1 (ACC1)

Specifications

Especificações e pureza

10mM in DMSO

Mecanismos bioquímicos e fisiológicos

CMS-121 is a quinolone derivative and an orally active acetyl-CoA carboxylase 1 (ACC1) inhibitor. CMS-121 protects HT22 cells against ischemia and oxidative damage with EC 50 values of 7 nM and 200 nM, respectively. CMS-121 has strong neuroprotective, ant

Condições de armazenamento de armazenamento

Store at -80°C

Enviado em

Dry ice packs + Cold packs

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Tipo de ação

INHIBITOR

Nomes e identificadores

• SMILES isoméricas: C1CCC(C1)OC2=CC(=NC3=CC=CC=C32)C4=CC(=C(C=C4)O)O
• CAS alternativo: 1353224-53-9
• PubChem CID: 135741221
• Peso molecular: 321.37

Perguntas frequentes

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 1353224-53-9, the molecular formula is C20H19NO3, and the molecular weight is 321.37 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.