Compound C108 - ≥98% , CAS No.15533-09-2

CAS: 15533-09-2 Cat. No.: C649291 Fórmula: C₁₅H₁₄N₂O₃ Peso molecular: 270.28 Número CE: 111-040-4 PubChem CID: 135472588

GRAU & PUREZA ≥98%

Storage

Protected from light,Store at -80°C

Shipped In

Dry ice packs + Cold packs

Visão geral

Compound C108 is a G3BP2 inhibitor. Compound C108 also targeted stress granule-associated proteins and Gtpase-activating protein (SH3 domain) binding protein 2. Compound C108 potently inhibits esophageal squamous cell carcinoma (ESCC) cell metastasis

In Vitro

Compound C108 (1 μM; 24 h) shows anti-tumor activity against BT474 cells. Compound C108 (4 μM; 24 h) significantly decreases the protein expression of G3BP2 in G3BP2 overexpressing KYSE410 cells and LINC01554 transfected KYSE30 cells. Compound C108 (4 μM; 24 h) attenuates ESCC cell metastasis, migration and invasion in KYSE410, KYSE30 and KYSE150 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: G3BP2-overexpressing KYSE410 cells, LINC01554-transfected KYSE30 cells Concentration: 4 μM Incubation Time: 24 h Result: Decreased the protein level of G3BP2 and HDGF.

In Vivo

Compound C108 (1 μM; 24 h) targets and decreases tumor initiating cells (TICs), while injected BT-474 cells treated with Compound C108 into the mammary fat pad of female nonobese diabetic/severe combined immune deficiency (NOD-SCID) mice in a limiting-dilution xenograft assay . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:G3BP2

Especificações

Especificações e pureza

≥98%

Mecanismos bioquímicos e fisiológicos

Compound C108 is a G3BP2 inhibitor. Compound C108 also targeted stress granule-associated proteins and Gtpase-activating protein (SH3 domain) binding protein 2. Compound C108 potently inhibits esophageal squamous cell carcinoma (ESCC) cell metastasis

Condições de armazenamento de armazenamento

Protected from light,Store at -80°C

Enviado em

Dry ice packs + Cold packs

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Tipo de ação

INHIBITOR

Pureza

≥98%

Nomes e identificadores

Sorrisos canónicos

CC(=NNC(=O)C1=CC=CC=C1O)C2=CC=CC=C2O

IUPAC Name

2-hydroxy-N-[(E)-1-(2-hydroxyphenyl)ethylideneamino]benzamide

InChIKey

LQGMBUGEAAGJKW-MHWRWJLKSA-N

INCHI

1S/C15H14N2O3/c1-10(11-6-2-4-8-13(11)18)16-17-15(20)12-7-3-5-9-14(12)19/h2-9,18-19H,1H3,(H,17,20)/b16-10+

PubChem CID

135472588

Peso molecular

270.28

Propriedades químicas e físicas

• Solubilidade: DMSO : 25 mg/mL (92.50 mM; Need ultrasonic)
• Peso molecular: 270.280 g/mol
• XLogP3: 2.900
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 270.1 Da
• Monoisotopic Mass: 270.1 Da
• Topological Polar Surface Area: 81.900 Ų
• Heavy Atom Count: 20
• Formal Charge: 0
• Complexity: 370.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 1
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 1
• Covalently-Bonded Unit Count: 1