CP-380736 - ≥98%(HPLC) , CAS No.179688-29-0

CAS: 179688-29-0 Cat. No.: C124695 Fórmula: C₁₄H₁₈N₂O₅ Peso molecular: 294.3 Número CE: 605-867-4

GRADE & PURITY ≥98%(HPLC)

Synonyms

AM20090625 | CCG-43571 | PF00520893CP 380736 | AS-11435 | 6,7-bis-(2-Methoxyethoxy)-quinazolin-4(3h)-one | 6,7-BIS(2-METHOXYETHOXY)QUINAZOLIN-4(3H)-ONE | AKOS025402163 | 6,7-bis-(2-methoxyethoxy)-4(3H)quinazolinone | 6,7-Bis-(2-methoxyethoxy)-4(3H)-quinaz

Storage

Room temperature,Argon charged

Shipped In

Normal

Visão geral

CP-380736 is an inhibitor of the epidermal growth factor receptor (EGFR). EGFR is a tyrosine kinase that activates MAPK, JNK, and Akt pathways, and is an important mediator of several types of cancer, including lung cancer and glioblastoma multiforme.

Specifications

Sinónimos

AM20090625 | CCG-43571 | PF00520893CP 380736 | AS-11435 | 6,7-bis-(2-Methoxyethoxy)-quinazolin-4(3h)-one | 6,7-BIS(2-METHOXYETHOXY)QUINAZOLIN-4(3H)-ONE | AKOS025402163 | 6,7-bis-(2-methoxyethoxy)-4(3H)quinazolinone | 6,7-Bis-(2-methoxyethoxy)-4(3H)-quinaz

Especificações e pureza

≥98%(HPLC)

Condições de armazenamento de armazenamento

Room temperature,Argon charged

Enviado em

Normal

Pureza

≥98%(HPLC)

Nomes e identificadores

• Pubchem Sid: 504773276
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504773276
• Sorrisos canónicos: COCCOC1=C(C=C2C(=C1)C(=O)NC=N2)OCCOC
• IUPAC Name: 6,7-bis(2-methoxyethoxy)-3H-quinazolin-4-one
• InChIKey: PMQWTUWLIGJTQD-UHFFFAOYSA-N
• INCHI: 1S/C14H18N2O5/c1-18-3-5-20-12-7-10-11(15-9-16-14(10)17)8-13(12)21-6-4-19-2/h7-9H,3-6H2,1-2H3,(H,15,16,17)
• SMILES isoméricas: COCCOC1=C(C=C2C(=C1)C(=O)NC=N2)OCCOC
• WGK Alemanha: 3
• Peso molecular: 294.3
• Reaxy-Rn: 10087641
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=10087641&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Classe Diazanaphthalenes
      • Subclass Benzodiazines

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Classe: Diazanaphthalenes
• Subclass: Benzodiazines
• Intermediate Tree Nodes: Not available
• Direct Parent: Quinazolines
• Alternative Parents: Pyrimidones Alkyl aryl ethers Benzenoids Vinylogous amides Heteroaromatic compounds Dialkyl ethers Azacyclic compounds Organopnictogen compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Quinazoline - Alkyl aryl ether - Pyrimidone - Pyrimidine - Benzenoid - Heteroaromatic compound - Vinylogous amide - Dialkyl ether - Ether - Azacycle - Organic nitrogen compound - Hydrocarbon derivative - Organic oxide - Organooxygen compound - Organonitrogen compound - Organopnictogen compound - Organic oxygen compound - Aromatic heteropolycyclic compound
• Descrição: This compound belongs to the class of organic compounds known as quinazolines. These are compounds containing a quinazoline moiety, which is made up of two fused six-member aromatic rings, a benzene ring and a pyrimidine ring.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Alvos associados (humanos)

JAK2 Tclin Tyrosine-protein kinase JAK2 (12915 Activities)

Discover Target: JAK2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mecanismos de ação

Propriedades químicas e físicas

• Sensibilidade: Air sensitive
• Ponto de fusão (°C): 192 °C
• Peso molecular: 294.300 g/mol
• XLogP3: 0.400
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 8
• Exact Mass: 294.122 Da
• Monoisotopic Mass: 294.122 Da
• Topological Polar Surface Area: 78.400 Ų
• Heavy Atom Count: 21
• Formal Charge: 0
• Complexity: 363.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Perguntas frequentes

What is the purity of this product, and how is it determined?

This product is supplied at ≥98% purity, determined by HPLC. Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at room temperature under argon. It is supplied under an argon blanket; reseal under inert gas after each use.

How is this product shipped?

This product ships under standard ambient conditions. No temperature-controlled packaging is required.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 179688-29-0, the molecular formula is C14H18N2O5, and the molecular weight is 294.3 g/mol. InChIKey PMQWTUWLIGJTQD-UHFFFAOYSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.