CSF1R-IN-1 - 10mM in DMSO , CAS No.2095849-04-8

CAS: 2095849-04-8 Cat. No.: C655027 Molecular Weight: 479.5 PubChem CID: 137333440

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

CSF1R-IN-1 is a CSF1R inhibitor with an with an IC 50 of 0.5 nM.

In Vitro

CSF1R is thought to play an important role in recruitment and differentiation of tumor-associated macrophages (TAMs). CSF1R-IN-1 (compound 22) shows good intestinal permeability in a Caco2 assay. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

CSF1R-IN-1 has favorable pharmacokinetics when dosed orally to mice. It appears suitable for in vivo pharmacology testing in the appropriate preclinical tumor model to demonstrate proof of concept. . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male CD-1 mice, 25-35 grams (8-11 weeks old) Dosage: 2 mg/kg IV or 10 mg/kg orally (Per Os) Administration: i.v. or oral Result: I.V.: C max =3.55, T 1/2 =0.87\nP.O.: C max =4.6, T 1/2 =1.8, Bioavailability=64%

IC50& Target:IC50: 0.5 nM (CSF1R)

Specifications

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

CSF1R-IN-1 is a CSF1R inhibitor with an with an IC 50 of 0.5 nM.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Names and Identifiers

• Isomeric SMILES: CC1=C(C=C(C=C1)NC(=O)C2=CC(=CC=C2)C(F)(F)F)NC(=O)C3=CN=CC(=C3)C4=CN(N=C4)C
• PubChem CID: 137333440
• Molecular Weight: 479.5

Associated Targets(Human)

CSF1R Tclin Macrophage colony-stimulating factor 1 receptor (4 Activities)

Discover Target: CSF1R

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)