CTB - ≥99% , CAS No.451491-47-7

CAS: 451491-47-7 Cat. No.: C646637 Fórmula: C₁₆H₁₃ClF₃NO₂ Peso molecular: 343.73 Número CE: 663-166-9 PubChem CID: 729859

GRAU & PUREZA ≥99%

Synonyms

CTB | DTXSID401016272 | MS-25265 | STL229939 | Cholera Toxin B Subunit | N-(4-chloro-3-(trifluoromethyl)phenyl)-2-ethoxybenzamide | Cholera Toxin B subunit, FITC conjugate, lyophilized powder | HMS3426C07 | YDXZSNHARVUYNM-UHFFFAOYSA-N | N-[4-chloro-3-(tri

Storage

Protected from light,Store at -80°C

Shipped In

Dry ice packs + Cold packs

Visão geral

CTB is a potent p300 histone acetyltransferase activator CTB can effectively induce apoptosis in MCF-7 cells .

In Vitro

CTB (10, 50, 100, 150, 200, and 250 μM; 10 min) enhances p300 HAT activity of p300 in a dosedependent manner. ?\nCTB (0-200 μM; 24 hours) inhibits the viability of MCF-7 cells with an IC 50 of 85.43 μM. ?\nCTB (85.43 μM; 24, 48 and 72 h) induces time dependence apoptosis of MCF-7 cells. ?\nCTB (50 uM; 24?h) increases p300/CBP activity , and reduces autophagic flux in primary neurons. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: MCF-7 cell Concentration: 0-200 μM Incubation Time: 24 hours Result: Inhibit viability with an IC 50 of 85.43 μM. Apoptosis AnalysisCell Line: MCF-7 cell Concentration: 85.43 μM Incubation Time: 24, 48 and 72 h Result: Iinduced time-dependence apoptosis.

Form:Solid

IC50& Target:CBP/p300

Especificações

Sinónimos

CTB | DTXSID401016272 | MS-25265 | STL229939 | Cholera Toxin B Subunit | N-(4-chloro-3-(trifluoromethyl)phenyl)-2-ethoxybenzamide | Cholera Toxin B subunit, FITC conjugate, lyophilized powder | HMS3426C07 | YDXZSNHARVUYNM-UHFFFAOYSA-N | N-[4-chloro-3-(tri

Especificações e pureza

≥99%

Mecanismos bioquímicos e fisiológicos

CTB is a potent p300 histone acetyltransferase activator. CTB can effectively induce apoptosis in MCF-7 cells.

Condições de armazenamento de armazenamento

Protected from light,Store at -80°C

Enviado em

Dry ice packs + Cold packs

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Tipo de ação

ACTIVATOR

Pureza

≥99%

Nomes e identificadores

Sorrisos canónicos

CCOC1=CC=CC=C1C(=O)NC2=CC(=C(C=C2)Cl)C(F)(F)F

IUPAC Name

N-[4-chloro-3-(trifluoromethyl)phenyl]-2-ethoxybenzamide

InChIKey

YDXZSNHARVUYNM-UHFFFAOYSA-N

INCHI

1S/C16H13ClF3NO2/c1-2-23-14-6-4-3-5-11(14)15(22)21-10-7-8-13(17)12(9-10)16(18,19)20/h3-9H,2H2,1H3,(H,21,22)

SMILES isoméricas

CCOC1=CC=CC=C1C(=O)NC2=CC(=C(C=C2)Cl)C(F)(F)F

WGK Alemanha

2

PubChem CID

729859

Peso molecular

343.73

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Classe Benzene and substituted derivatives
      • Subclass Anilides
        • Level5 Aromatic anilides
          • Level6 Benzanilides

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Classe: Benzene and substituted derivatives
• Subclass: Anilides
• Intermediate Tree Nodes: Aromatic anilides
• Direct Parent: Benzanilides
• Alternative Parents: Trifluoromethylbenzenes Benzamides Benzoyl derivatives Phenol ethers Phenoxy compounds Chlorobenzenes Alkyl aryl ethers Aryl chlorides Secondary carboxylic acid amides Organonitrogen compounds Organofluorides Organochlorides Organic oxides Hydrocarbon derivatives Organopnictogen compounds Alkyl fluorides
• Molecular Framework: Aromatic homomonocyclic compounds
• Substituents: Benzanilide - Trifluoromethylbenzene - Benzamide - Benzoic acid or derivatives - Phenoxy compound - Phenol ether - Benzoyl - Alkyl aryl ether - Chlorobenzene - Halobenzene - Aryl chloride - Aryl halide - Secondary carboxylic acid amide - Carboxamide group - Carboxylic acid derivative - Ether - Organopnictogen compound - Organofluoride - Organic oxygen compound - Organonitrogen compound - Organooxygen compound - Alkyl fluoride - Organic nitrogen compound - Hydrocarbon derivative - Organic oxide - Alkyl halide - Organochloride - Organohalogen compound - Aromatic homomonocyclic compound
• Descrição: This compound belongs to the class of organic compounds known as benzanilides. These are aromatic compounds containing an anilide group in which the carboxamide group is substituted with a benzene ring. They have the general structure RNC(=O)R', where R,R'= benzene.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Propriedades químicas e físicas

• Solubilidade: DMSO : 100 mg/mL (290.93 mM; Need ultrasonic)
• Peso molecular: 343.730 g/mol
• XLogP3: 4.600
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 4
• Exact Mass: 343.059 Da
• Monoisotopic Mass: 343.059 Da
• Topological Polar Surface Area: 38.300 Ų
• Heavy Atom Count: 23
• Formal Charge: 0
• Complexity: 405.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1