D-Lactic Acid - Moligand™, ≥90%(T) , Agonist of HCA 1 receptor, CAS No.10326-41-7, Agonist of HCA 1 receptor

CAS: 10326-41-7 Cat. No.: S161106 Molecular Weight: 90.08 EC Number: 233-713-2

GRADE & PURITY Moligand™, ≥90%(T)

Synonyms

(D)-(-)-Lactic acid | (R)-lactate | (R)-2-Hydroxypropionate | D-2-Hydroxypropionic acid | D-(-)-Lactate | D-LACTIC ACID [WHO-DD] | AS-19478 | HY-111095 | (R)-2-Hydroxypropionic acid(R)-2-Hydroxypropionic acid | (R)-alpha-Hydroxypropionate | D-Lactic acid

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

Lactic acid is used as a reagent in organic synthesis (in the manufacture of adhesives). It is used in the leather, textile, and tanning industries. It may be used as a plasticizer, a catalyst, or an acidifying agent. Lactic acid has even been used as a flavoring agent in the manufacture of tobacco products.

Specifications

Synonyms

(D)-(-)-Lactic acid | (R)-lactate | (R)-2-Hydroxypropionate | D-2-Hydroxypropionic acid | D-(-)-Lactate | D-LACTIC ACID [WHO-DD] | AS-19478 | HY-111095 | (R)-2-Hydroxypropionic acid(R)-2-Hydroxypropionic acid | (R)-alpha-Hydroxypropionate | D-Lactic acid

Specifications & Purity

Moligand™, ≥90%(T)

Biochemical and Physiological Mechanisms

In animals, lactic acid is a metabolic compound produced by proliferating cells and during anaerobic conditions such as strenuous exercise. Lactic acid can be oxidized back to pyruvate or converted to glucose via gluconeogenesis. Lactic acid is preferenti

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

AGONIST

Mechanism of action

Agonist of HCA 1 receptor

Purity

≥90%(T)

Names and Identifiers

• Pubchem Sid: 528764015
• Canonical Smiles: CC(C(=O)O)O
• IUPAC Name: (2R)-2-hydroxypropanoic acid
• InChIKey: JVTAAEKCZFNVCJ-UWTATZPHSA-N
• INCHI: 1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/t2-/m1/s1
• Isomeric SMILES: C[C@H](C(=O)O)O
• Molecular Weight: 90.08
• Reaxy-Rn: 1209341
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1209341&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic acids and derivatives
    • Class Hydroxy acids and derivatives
      • Subclass Alpha hydroxy acids and derivatives

• Kingdom: Organic compounds
• Superclass: Organic acids and derivatives
• Class: Hydroxy acids and derivatives
• Subclass: Alpha hydroxy acids and derivatives
• Intermediate Tree Nodes: Not available
• Direct Parent: Alpha hydroxy acids and derivatives
• Alternative Parents: Secondary alcohols Monocarboxylic acids and derivatives Carboxylic acids Organic oxides Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aliphatic acyclic compounds
• Substituents: Alpha-hydroxy acid - Secondary alcohol - Monocarboxylic acid or derivatives - Carboxylic acid - Carboxylic acid derivative - Organic oxygen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Carbonyl group - Alcohol - Aliphatic acyclic compound
• Description: This compound belongs to the class of organic compounds known as alpha hydroxy acids and derivatives. These are organic compounds containing a carboxylic acid substituted with a hydroxyl group on the adjacent carbon.
• External Descriptors: 2-hydroxypropanoic acid

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

HCAR1 Tchem Hydroxycarboxylic acid receptor 1 (1 Activities)

Discover Target: HCAR1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SLC16A1 Tchem Monocarboxylate transporter 1 (146 Activities)

Discover Target: SLC16A1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SLCO2B1 Tchem Solute carrier organic anion transporter family member 2B1 (580 Activities)

Discover Target: SLCO2B1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SLC16A3 Tchem Monocarboxylate transporter 4 (196 Activities)

Discover Target: SLC16A3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SLC16A7 Tchem Monocarboxylate transporter 2 (11 Activities)

Discover Target: SLC16A7

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SLC16A10 SLC16A10 protein (28 Activities)

Discover Target: SLC16A10

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Slco2a1 Solute carrier organic anion transporter family member 2A1 (47 Activities)

Discover Target: Slco2a1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Slc16a10 Monocarboxylate transporter 10 (73 Activities)

Discover Target: Slc16a10

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Chemical and Physical Properties

• Solubility: Soluble in water (50mg/ml)
• Sensitivity: heat sensitive
• Refractive Index: 1.43
• Specific Rotation[α]: 13° (C=2.5,1.5mol/L NaOH)
• Flash Point(°C): 110 °C
• Molecular Weight: 90.080 g/mol
• XLogP3: -0.700
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 90.0317 Da
• Monoisotopic Mass: 90.0317 Da
• Topological Polar Surface Area: 57.500 Ų
• Heavy Atom Count: 6
• Formal Charge: 0
• Complexity: 59.100
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 1
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

References

1. Rongxiu Qin, Haiyan Chen, Rusi Wen, Guiqing Li, Zhonglei Meng.  (2023)  Effect of Boric Acid on the Ionization Equilibrium of α-Hydroxy Carboxylic Acids and the Study of Its Applications.  MOLECULES,  28  (12): (4723).  [PMID:37375278] [10.3390/molecules28124723]

2. Xiao Zheng, Ying Liu, Yiqiong Liu, Tingting Zhang, Yuge Zhao, Jie Zang, Yan Yang, Ruiqing He, Gaowei Chong, Shuangrong Ruan, Dailin Xu, Yongyong Li, Haiqing Dong.  (2022)  Dual Closed-Loop of Catalyzed Lactate Depletion and Immune Response to Potentiate Photothermal Immunotherapy.  ACS Applied Materials & Interfaces,      [PMID:35578899] [10.1021/acsami.2c07254]

3. Jie Sun, Yaping Wang, Zhenguo Gao, Junbo Gong, Weiwei Tang.  (2022)  Additive-assisted preferential crystallization of racemic component: A case of norvaline.  JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY,      [PMID:] [10.1016/j.jiec.2022.02.054]

4. Jianjian Zhao, Aiyou Hao, Pengyao Xing.  (2021)  Enhancing Optical Activities of Benzimidazole Derivatives through Coassembly for High-Efficiency Synthesis of Chiroptical Nanomaterials and Accurate ee % Detection of Natural Acids.  ACS Applied Materials & Interfaces,      [PMID:33502861] [10.1021/acsami.0c20735]

5. Kaiyang Ma, Xiao Ding, Qiqi Song, Zhitao Han, Hang Yao, Jianhua Ding, Gang Hu.  (2020)  Lactate enhances Arc/arg3.1 expression through hydroxycarboxylic acid receptor 1-β-arrestin2 pathway in astrocytes.  NEUROPHARMACOLOGY,      [PMID:32294462] [10.1016/j.neuropharm.2020.108084]

6. Shengli Mi, Jingjing Xia, Yuanyuan Xu, Zhichang Du, Wei Sun.  (2019)  An integrated microchannel biosensor platform to analyse low density lactate metabolism in HepG2 cells in vitro.  RSC Advances,  9  (16): (9006-9013).  [PMID:35517697] [10.1039/C9RA00694J]

7. Ai-Ling Hu, Yin-Huan Liu, Hao-Hua Deng, Guo-Lin Hong, Ai-Lin Liu, Xin-Hua Lin, Xing-Hua Xia, Wei Chen.  (2014)  Fluorescent hydrogen peroxide sensor based on cupric oxide nanoparticles and its application for glucose and l-lactate detection.  BIOSENSORS & BIOELECTRONICS,      [PMID:24912038] [10.1016/j.bios.2014.05.048]

8. Chen Chen, Ziwei Liu, Jianzheng Li, Davide Vurro, Yizhou Jiang, Luyu Xue, Ye Gong, Yaje Qin.  (2024)  A Miniaturized Flexible Patch Based on CNT Fiber Sensors and Highly Integrated SoC for Analysis of Sweat.  IEEE SENSORS JOURNAL,      [PMID:] [10.1109/JSEN.2024.3465048]

9. Qing Li, Congnan Wu, Jiaxing Zhang, Rongxin Su, Yuefei Wang, Wei Qi.  (2024)  Construction of chiral nanozymes with high enantioselectivity for visual detection via smartphone-based paper sensors.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2024.153326]

10. Xinwen Jia, Mengyun Lu, Wenjing Zhang, Wuduo Zhao, Ajuan Yu, Shusheng Zhang.  (2024)  Fluorescence enantioselective sensing of lactic acid enantiomers by Zn-MOC@CQDs with double chiral building blocks.  MICROCHEMICAL JOURNAL,      [PMID:] [10.1016/j.microc.2024.112575]

11. Jing Zhang, Zishuo Fang, Heng Dong, Yu Liu, Zhenyu Chu, Yongbin Mou, Wanqin Jin.  (2024)  MnFe@N-CNTs Based Lactate Biomicrochips for Nonintrusive and Onsite Periodontitis Diagnosis.  ACS Applied Materials & Interfaces,      [PMID:38593051] [10.1021/acsami.4c00979]

12. Ling Ding, Lou Gao, Di Pan, Ke Du, Jiayu Yu, Wanyi Li, Yahong Zhang, Yi Tang.  (2024)  Reducing meso-lactide formation from racemic lactic acid using shape-selective H-Beta zeolite.  Catalysis Science & Technology,      [PMID:] [10.1039/D4CY01046A]

13. Zhonglei Meng, Rongxiu Qin, Rusi Wen, Junkang Xie, Guiqing Li, Yonghong Zhou.  (2024)  Synthesis of terpinyl acetate from α-pinene catalyzed by α-hydroxycarboxylic acid–boric acid composite catalyst.  PLoS One,  19  (4): (e0299218).  [PMID:38662654] [10.1371/journal.pone.0299218]

14. Yanwei Wang, Jiahui Zhao, Yong Chen, Xuesong Liu, Tengfei Xu, Mingliang Fang.  (2025)  Revealing Ferroptosis Induction by Bisphenol A and Bisphenol S through Distinct Protein Targets.  ENVIRONMENTAL SCIENCE & TECHNOLOGY,      [PMID:41068997] [10.1021/acs.est.5c08855]

15. Yichen Liu, Dahai Hou, Hui Wang, Qiuying Yan, Yunzhu Xu, Qibiao Wu, Dan Dong, Weixing Shen, Weiwei Tao, Haibo Cheng, Dongdong Sun.  (2025)  A Bufalin and CRISPR/Cas9 Ribonucleoprotein-Loaded Calcium Lactate Nanomedicine for Pyroptosis/Apoptosis and Synergistic Cancer Immunotherapy.  Materials Today Bio,      [PMID:41322154] [10.1016/j.mtbio.2025.102527]

16. Shaorui Qi, Lei Sun, Fansheng Meng, Guimei Shi, Yunlong Sun, Bo Jiang, Junbo Li, Yukihiro Ozaki, Wei Ji.  (2026)  Charge-Transfer-Driven Enantioselective Surface-Enhanced Raman Scattering on a ZIF-8/ZnS Heterojunction: A Chiral-Label-Free Biosensor for Quantification of Urinary Lactate Enantiomeric Excess.  ACS Sensors,      [PMID:41568656] [10.1021/acssensors.5c03836]

17. Jin Li, Mengyi Yang, Rui Xing, Jingmei Pan, Xing Guo, Shaobing Zhou.  (2026)  Reversing neuroinflammation in ischemic stroke through efferocytotic phenotype reprogramming with polymeric nanoparticles.  BIOMATERIALS,      [PMID:41895020] [10.1016/j.biomaterials.2026.124156]

18. Dong Guo, Ying Meng, Qingqing Yang, Shudi Luo, Xiaoming Jiang, Yanhua Zheng, Lihui Wu, Suyao Li, Hongfei Jiang, Shan Li, Zheng Wang, Min Li, Qingang Wu, Liwei Xiao, Rongxuan Zhu, Xuxiao He, Yanyan Hu, Hong Zhao, Xianglai Ye, Yingying Tong, Jing Fang, Daqian Xu, Jun Xu, Ying Yuan, Zhimin Lu.  (2026)  Lactate binds and inhibits the innate immune sensor STING to promote tumor immune evasion.  IMMUNITY,      [PMID:42379164] [10.1016/j.immuni.2026.06.004]

19. Siyu Pan, Xuanyi Lu, Wenjie Yang, Yunhui Peng, Lingfu Deng, Shuai Zha, Xueyang Fang, Guochen Bao, Lijun Jiang.  (2026)  Near-infrared light-activated aptamer-based nanoprobe for spatiotemporally resolved detection of L-lactate in colorectal cancer.  BMEMat,      [PMID:] [10.1002/bmm2.70123]