D-(+)-Vesamicol hydrochloride - solid , CAS No.112709-60-1

CAS: 112709-60-1 Cat. No.: D477156 Fórmula: C₁₇H₂₆ClNO Peso molecular: 295.85 Número CE: 634-539-3

GRADE & PURITY solid

Synonyms

D-(+)-Vesamicol hydrochloride | D(+)-Vesamicol hydrochloride | (1S,2S)-Cyclohexanol, 2-(4-phenyl-1-piperidinyl)-, hydrochloride | AT38144 | (1S,2S)-2-(4-phenylpiperidin-1-yl)cyclohexanol hydrochloride | D-(+)-Vesamicol hydrochloride, solid | (1S,2S)-2-(4-

Storage

Room temperature

Visão geral

Description

D-(+)-Vesamicol is a potent inhibitor of acetycholine transport into the synaptic vesicles in cholinergic nerve terminals. It is 25-times less potent than the L-form.D-(+)-Vesamicol hydrochloride can be used as a reactant to prepare:Trialkylstannyl vesamicol analogs as potent vesicular acetylcholine transporters (VAChTs) and sigma receptors.Vesamicol analog, (+)-2-[4-(4-iodophenyl)piperidino] cyclohexanol as a possible tumor imaging agent.

Specifications

Sinónimos

D-(+)-Vesamicol hydrochloride | D(+)-Vesamicol hydrochloride | (1S,2S)-Cyclohexanol, 2-(4-phenyl-1-piperidinyl)-, hydrochloride | AT38144 | (1S,2S)-2-(4-phenylpiperidin-1-yl)cyclohexanol hydrochloride | D-(+)-Vesamicol hydrochloride, solid | (1S,2S)-2-(4-

Especificações e pureza

solid

Mecanismos bioquímicos e fisiológicos

Less active enantiomer of vesamicol

Condições de armazenamento de armazenamento

Room temperature

Nomes e identificadores

• Sorrisos canónicos: C1CCC(C(C1)N2CCC(CC2)C3=CC=CC=C3)O.Cl
• IUPAC Name: (1S,2S)-2-(4-phenylpiperidin-1-yl)cyclohexan-1-ol;hydrochloride
• InChIKey: XJNUHVMJVWOYCW-QJHJCNPRSA-N
• INCHI: 1S/C17H25NO.ClH/c19-17-9-5-4-8-16(17)18-12-10-15(11-13-18)14-6-2-1-3-7-14;/h1-3,6-7,15-17,19H,4-5,8-13H2;1H/t16-,17-;/m0./s1
• SMILES isoméricas: C1CC[C@@H]([C@H](C1)N2CCC(CC2)C3=CC=CC=C3)O.Cl
• WGK Alemanha: 3
• RTECS: GW0765070
• Peso molecular: 295.85
• Reaxy-Rn: 11000520
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=11000520&ln=

Alvos associados (humanos)

SLC18A3 Tchem Vesicular acetylcholine transporter (0 Activities)

Discover Target: SLC18A3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Propriedades químicas e físicas

• Solubilidade: DMSO: soluble; ethanol: soluble