DA 3003-2 is a potent and selectively Cdc25 inhibitor. DA 3003-2 shows antiproliferative activity. DA 3003-2 induces cell cycle arrest at the G2/M phase and increases the expression of P-tyr 15 Cdc2. DA 3003-2 has the potential for the research of prostate cancer.
In Vitro
DA 3003-2 (0.3-30 µM; 48 h) shows antiproliferative activity with an IC 50 value of 5 µM in PC-3 cells. DA 3003-2 (5, 10 µM; 24, 1 h) induces cell cycle arrest at G2/M phase and increases the expression of P-tyr 15 Cdc2 in PC-3 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Cytotoxicity AssayCell Line: PC-3 cells Concentration: 0.3-30 µM Incubation Time: 48 h Result: Showed antiproliferative efficacy in a dose-dependent manner with an IC 50 value of 5 µM. Cell Cycle AnalysisCell Line: PC-3 cells Concentration: 5, 10 µM Incubation Time: 24 h Result: Induced cell cycle arrest at G2/M phase. Western Blot AnalysisCell Line: PC-3 cells Concentration: 5, 10 µM Incubation Time: 1 h Result: Increased the expression of P-tyr 15 Cdc2.
Form:Solid
Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Organoheterocyclic compounds |
| Classe | Quinolines and derivatives |
| Subclass | Quinoline quinones |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Quinoline quinones |
| Alternative Parents | Hydroquinolines Aryl ketones Morpholines Pyridines and derivatives Vinylogous halides Alpha-chloroketones Vinylogous amides Heteroaromatic compounds Trialkylamines Oxacyclic compounds Enamines Dialkylamines Dialkyl ethers Chloroalkenes Azacyclic compounds Vinyl chlorides Organopnictogen compounds Organochlorides Organic oxides Hydrocarbon derivatives |
| Molecular Framework | Aromatic heteropolycyclic compounds |
| Substituents | Quinoline quinone - Dihydroquinoline - Aryl ketone - Morpholine - Oxazinane - Pyridine - Alpha-haloketone - Alpha-chloroketone - Heteroaromatic compound - Vinylogous amide - Vinylogous halide - Ketone - Tertiary amine - Tertiary aliphatic amine - Dialkyl ether - Secondary aliphatic amine - Enamine - Ether - Oxacycle - Secondary amine - Azacycle - Chloroalkene - Vinyl chloride - Vinyl halide - Haloalkene - Organonitrogen compound - Organooxygen compound - Organic oxide - Hydrocarbon derivative - Amine - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Organohalogen compound - Organochloride - Aromatic heteropolycyclic compound |
| Descrição | This compound belongs to the class of organic compounds known as quinoline quinones. These are quinoline derivative with a structure containing a 5,8-dihydroisoquinoline-5,8-dione skeleton. |
| External Descriptors | Not available |
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
| Solubilidade | DMSO : 150 mg/mL (466.19 mM; Need ultrasonic) |
|---|---|
| Peso molecular | 321.760 g/mol |
| XLogP3 | 1.400 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 6 |
| Rotatable Bond Count | 4 |
| Exact Mass | 321.088 Da |
| Monoisotopic Mass | 321.088 Da |
| Topological Polar Surface Area | 71.500 Ų |
| Heavy Atom Count | 22 |
| Formal Charge | 0 |
| Complexity | 488.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
