EHT 1864 2HCl - 10mM in DMSO , CAS No.754240-09-0

CAS: 754240-09-0 Cat. No.: E408927 Fórmula: C₂₅H₂₇F₃N₂O₄S•2HCl Peso molecular: 581.47 Número CE: 695-652-1 PubChem CID: 9938202

GRADE & PURITY 10mM in DMSO

Synonyms

2-(4-morpholinylmethyl)-5-[[5-[[7-(trifluoromethyl)-4-quinolinyl]thio]pentyl]oxy]-4H-pyran-4-one,hydrochloride (1:2)

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Visão geral

Information

EHT 1864 2HCl EHT 1864 2HCl is a potent Rac family GTPase inhibitor with K d of 40 nM, 50 nM, 60 nM and 250 nM for Rac1, Rac1b, Rac2 and Rac3, respectively.
In vitro

EHT 1864 selectively inhibits Rac-induced lamellipodia formation, and specifically reverses cell transformation induced by constitutively activated mutants of Rac1 and Tiam1. EHT 1864 strongly impaires oncogenic Ras-induced cell proliferation in NIH 3T3 cells stably expressing H-Ras(61L) protein. EHT 1864 also reduces both extracellular and intracellular levels of Aβ peptides by inhibiting the γ-secretase-dependent cleavage of APP. In cultured hippocampal pyramidal neurons, EHT 1864, via inhibition of Rac1, rescues the phenotype induced by Rich2 knock-down.

In vivo

EHT 1864 (40 mg/kg i.p.) significantly reduces Abeta 40 and Abeta 42 levels in guinea pig brains.
Cell Data

cell lines：

Concentrations：~5 μM

Incubation Time：4 days

Powder Purity:≥99%

Specifications

Sinónimos

2-(4-morpholinylmethyl)-5-[[5-[[7-(trifluoromethyl)-4-quinolinyl]thio]pentyl]oxy]-4H-pyran-4-one,hydrochloride (1:2)

Especificações e pureza

10mM in DMSO

Mecanismos bioquímicos e fisiológicos

EHT 1864 2HCl is a potent Rac family GTPase inhibitor with K_d of 40 nM, 50 nM, 60 nM and 250 nM for Rac1, Rac1b, Rac2 and Rac3, respectively.

Condições de armazenamento de armazenamento

Store at -80°C

Enviado em

Dry ice packs + Cold packs

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Tipo de ação

INHIBITOR

Nomes e identificadores

SMILES isoméricas

C1COCCN1CC2=CC(=O)C(=CO2)OCCCCCSC3=C4C=CC(=CC4=NC=C3)C(F)(F)F.Cl.Cl

WGK Alemanha

3

PubChem CID

9938202

Peso molecular

581.47