EN219 - ≥98% , CAS No.380351-29-1

CAS: 380351-29-1 Cat. No.: E651926 Fórmula: C₁₇H₁₃Br₂ClN₂O Peso molecular: 456.56

GRAU & PUREZA ≥98%

Storage

Store at 2-8°C,Protected from light,Desiccated

Shipped In

Wet ice

Application

230

Visão geral

EN219 is a moderately selective synthetic covalent ligand against an N-terminal cysteine (C8) of RNF114 with an IC 50 of 470 nM. EN219 inhibits RNF114-mediated autoubiquitination and p21 ubiquitination

In Vitro

EN219 (1 μM; 90 min) interacts with RNF114 C8, TUBB1 C201, HSPD1 C442, and HIST1H3A C97 demonstrated by isotopic tandem orthogonal proteolysisABPP (isoTOP-ABPP) analysis. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:RNF114 470 nM (IC 50 )

Especificações

Especificações e pureza

≥98%

Mecanismos bioquímicos e fisiológicos

EN219 is a moderately selective synthetic covalent ligand against an N-terminal cysteine (C8) of RNF114 with an IC 50 of 470 nM. EN219 inhibits RNF114-mediated autoubiquitination and p21 ubiquitination.

Condições de armazenamento de armazenamento

Store at 2-8°C,Protected from light,Desiccated

Enviado em

Wet ice

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Pureza

≥98%

Nomes e identificadores

Sorrisos canónicos

ClCC(N1N=C(C2=CC=C(Br)C=C2)CC1C3=CC=C(Br)C=C3)=O

Peso molecular

456.56

Propriedades químicas e físicas

• Solubilidade: DMSO : 65 mg/mL (142.37 mM; Need ultrasonic)