Enrofloxacin monohydrochloride - 10mM in Water , CAS No.93106-59-3

CAS: 93106-59-3 Cat. No.: E655966 Fórmula: C₁₉H₂₃ClFN₃O₃ Peso molecular: 395.86 Número CE: 688-293-7 PubChem CID: 45357113

GRADE & PURITY 10mM in Water

Storage

Desiccated,Store at -80°C

Shipped In

Dry ice packs + Cold packs

Visão geral

Enrofloxacin monohydrochloride (BAY Vp 2674 monohydrochloride) is an effective antibiotic with an MIC 90 of 0.312 μg/mL for Mycoplasma bovis . Enrofloxacin monohydrochloride shows inhibitory activity against vaccinia virus (VV).

In Vitro

Mycoplasma bovis is a worldwide pathogen, causative agent of pneumonia, mastitis, arthritis, and a variety of other symptoms in cattle. The antibiotic susceptibility profiles of the Hungarian strains are consistent within the tested group of fluoroquinolones. Three isolates (MYC44, MYC45 and MYC46) have high MIC values (≥10 μg/mL) to Enrofloxacin, while the rest of the strains are inhibited by Enrofloxacin with MICs ≤0.312 or 0.625 μg/mL. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Mice (n=80) undergo transient middle cerebral artery occlusion (MCAo) with reperfusion after 60 minutes. After MCAo, animals are randomly assigned to receive either a daily preventive medication (n=26, Enrofloxacin) starting at the day of MCAo or a therapeutic medication (n=25; Enrofloxacin) after diagnosis of lung infection. Standard treatment started immediately after the appearance of clinical signs (general health score>6) usually between day 4 and 6 after stroke. Both, preventive and standard antibiotic treatment using Enrofloxacin improve survival in a similar way compared with placebo treatment. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal administration

Mice 11- to 14-week-old C57Bl6/J male mice are used. Enrofloxacin (2.5% oral solution) is dispensed in saline (2 mg/mL), antibiotic-treated animals receive a daily orally dispensed dose of 10 mg/kg body weight via feeding needle every 12 hours over a period of 7 days, while placebo animals receive the same amount of saline via feeding needle. Animals of preventive antibiotic group obtained Enrofloxacin after waking from reperfusion anesthesia (ca. 1 hour after operation). Therapeutic antibiotic treatment is given immediately after appearance of clinical signs (general health score>5) and confirmation of lung infection by MRI (signal rate≥5%). The group allocation is randomized . aladdin has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:Quinolone

Specifications

Especificações e pureza

10mM in Water

Mecanismos bioquímicos e fisiológicos

Enrofloxacin monohydrochloride (BAY Vp 2674 monohydrochloride) is an effective antibiotic with an MIC 90 of 0.312 μg/mL for Mycoplasma bovis . Enrofloxacin monohydrochloride shows inhibitory activity against vaccinia virus (VV).

Condições de armazenamento de armazenamento

Desiccated,Store at -80°C

Enviado em

Dry ice packs + Cold packs

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Tipo de ação

INHIBITOR

Nomes e identificadores

SMILES isoméricas

CCN1CCN(CC1)C2=C(C=C3C(=C2)N(C=C(C3=O)C(=O)O)C4CC4)F.Cl

CAS alternativo

112732-17-9

PubChem CID

45357113

Peso molecular

395.86

Perguntas frequentes

How should this product be stored?

Store at ?80 °C, desiccated. Keep the container tightly closed with desiccant — the material is moisture-sensitive.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 93106-59-3, the molecular formula is C19H23ClFN3O3, and the molecular weight is 395.86 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.