EOC317 - 10mM in DMSO , CAS No.939805-30-8

CAS: 939805-30-8 Cat. No.: E655169 Fórmula: C₂₇H₂₆F₅N₇O₃ Peso molecular: 591.53 PubChem CID: 23653175

GRAU & PUREZA 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Visão geral

EOC317 (ACTB-1003) is an oral kinase inhibitor with IC 50 s of 6, 2 and 4 nM for FGFR1 , VEGFR2 and Tie-2 .

In Vitro

EOC317 (ACTB-1003) is an oral kinase inhibitor with multiple modes of action, targeting cancer mutations via FGFR inhibition FGFR1 (IC 50 =6 nM), angiogenesis through inhibition of VEGFR2 (2 nM), Tie-2 (4 nM), and induces apoptosis likely by targeting RSK (5 nM) and p70S6K (32 nM). EOC317 is highly active with dose-dependent tumor growth inhibition in cell lines with FGFR genetic alterations-OPM2 human multiple myeloma and the murine leukemia Ba/F3-TEL-FGFR1. OPM2 cells harbor the FGFR3 t(4:14) translocation, FGFR3 K650E mutation and PTEN deletion while the Ba/F3-TEL-FGFR1 cells are driven by FGFR1 over-expression. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

EOC317 (ACTB-1003) is shown to inhibit tumor angiogenesis evident by the inhibition of CD31 staining in tumor sections. EOC317 is combinable with 5-FU or paclitaxel without diminishing the activity or increasing the toxicity of these chemotherapy agents in the HCT-116 colon tumor xenograft model . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:FGFR1 6 nM (IC 50 ) VEGFR2 2 nM (IC 50 ) Tie-2 4 nM (IC 50 )

Especificações

Especificações e pureza

10mM in DMSO

Mecanismos bioquímicos e fisiológicos

EOC317 (ACTB-1003) is an oral kinase inhibitor with IC 50 s of 6, 2 and 4 nM for FGFR1 , VEGFR2 and Tie-2 .

Condições de armazenamento de armazenamento

Store at -80°C

Enviado em

Dry ice packs + Cold packs

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Tipo de ação

INHIBITOR

Nomes e identificadores

SMILES isoméricas

COCC1=C(N2C(=C1C3=CC(=C(C=C3)NC(=O)NC4=C(C=CC(=C4)C(F)(F)F)F)F)C(=NC=N2)N)CN5CCOCC5

PubChem CID

23653175

Peso molecular

591.53