Epothilone A - 10mM in DMSO , CAS No.152044-53-6

CAS: 152044-53-6 Cat. No.: E409291 Fórmula: C₂₆H₃₉NO₆S Peso molecular: 493.66

GRAU & PUREZA 10mM in DMSO

Synonyms

(1S,3S,7S,10R,11S,12S,16R,E)-7,11-dihydroxy-8,8,10,12-tetramethyl-3-(1-(2-methylthiazol-4-yl)prop-1-en-2-yl)-4,17-dioxa-bicyclo[14.1.0]heptadecane-5,9-dione

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Visão geral

Information

Epothilone A Epothilone A is a paclitaxel-like microtubule -stabilizing agent with EC 0.01 of 2 μM.
In vitro

Epothilone A, discovered from the myxobacterium Sorangium cellulosum, is a Taxol-like microtubule-stabilizing agent that induces tubulin polymerization, leading to cell cycle arrest at the G2-M transition, cytotoxicity, and apoptosis.Epothilone A potently inhibits cell proliferation in HCT116 cells, with IC50 of 4.4 nM. Epothilone A also displays cytotoxicity in KB3-1, KBV-1, Hela, and Hs578T cells, with IC50 values ranging from 13 nM to 160 nM. Epothilone A is more water soluble than Taxol and competes with Taxol in binding with microtubules, with IC50 of 2.3 μM. However, both Epothilone A and Taxol don\'t share a common pharmacophore and exploits the tubulin-binding pocket uniquely and independently. Recently, it is found that microbiological transformation of Epothilone A by Aspergillus niger AS 3.739 yields several metabolites that is also toxic to MCF-7 cells, but with much higher IC50 values.

In vivo

Cell Data

cell lines：A431, MO7e, HUVEC and NHDF cells

Concentrations：0–2 μM

Incubation Time：24 hours for mitotic arrest or 72 hours for cytotoxicity

Powder Purity:≥98%

Especificações

Sinónimos

(1S,3S,7S,10R,11S,12S,16R,E)-7,11-dihydroxy-8,8,10,12-tetramethyl-3-(1-(2-methylthiazol-4-yl)prop-1-en-2-yl)-4,17-dioxa-bicyclo[14.1.0]heptadecane-5,9-dione

Especificações e pureza

10mM in DMSO

Mecanismos bioquímicos e fisiológicos

Epothilone A is a paclitaxel-like microtubule-stabilizing agent with EC_0.01 of 2 μM.

Condições de armazenamento de armazenamento

Store at -80°C

Enviado em

Dry ice packs + Cold packs

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Nomes e identificadores

SMILES isoméricas

C[C@H]1CCC[C@@H]2[C@@H](O2)C[C@H](OC(=O)C[C@@H](C(C(=O)[C@@H]([C@H]1O)C)(C)C)O)/C(=C/C3=CSC(=N3)C)/C

WGK Alemanha

3

Peso molecular

493.66

Reaxy-Rn

26220988

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=26220988&ln=