Ethynodiol diacetate - Moligand™, 10mM in DMSO , Progesterone receptor agonist, CAS No.297-76-7, Progesterone receptor agonist

CAS: 297-76-7 Cat. No.: E408955 Fórmula: C₂₄H₃₂O₄ Peso molecular: 384.51 Número CE: 206-044-9

GRAU & PUREZA Moligand™, 10mM in DMSO

Synonyms

8080 CB | 19-Norpregn-4-en-20-yne-3,17-diol, 3,17-diacetate, (3β,17α)-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Visão geral

Information

Ethynodiol diacetate (8080 CB) is one of the first synthetic progestogens used in contraceptive pills.
In vitro

Nordihydroguaiaretic acid (NDGA) (< 1.5 μM) decreases the percentage of sister chronnatid exchanges (SCEs) in human lymphocyte culture treated with ethynodiol diacetate (150 μg/mL). Since the NDGA treatment, in the presence of S9 mix, reduce the genotoxic damage by ethynodiol diacetate, the reduction may be due to the inhibition of cytochrome P450s which prevents the metabolic activation of ethynodiol diacetate or NDGA may act as a free radical scavenger. Ethynodiol diacetate (150 μg/mL) increases sister chromatid exchanges (SCEs) and chromosomal aberrations (CAs) frequencies and inhibits lymphocyte proliferation in the presence of S9 mix in human lymphocyte.

In vivo

Ethynodiol diacetate (6 mg/kg b.w. daily) significantly increases the amounts of excreted 3alpha-hydroxy-5alpha-pregnan-20-one and A-homo-3-oxa-5alpha-pregnane-4,20-dione in urine in female rats. Significant increase in the weights of pituitary, liver and kidneys are noted in rats treated with ethynodiol diacetate (6 mg/kg b.w. daily). Norgestrel (75 μg/day) and ethynodiol diacetate (150 μg/day), co-administered with ethinyl estradiol (7.5 μg/day), lowers the plasma concentrations of HDL cholesterol in cynomolgus monkeys.
Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

Especificações

Sinónimos

8080 CB | 19-Norpregn-4-en-20-yne-3,17-diol, 3,17-diacetate, (3β,17α)-

Especificações e pureza

Moligand™, 10mM in DMSO

Mecanismos bioquímicos e fisiológicos

Ethynodiol diacetate (8080 CB) is one of the first synthetic progestogens used in contraceptive pills.

Condições de armazenamento de armazenamento

Store at -80°C

Enviado em

Dry ice packs + Cold packs

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Grau

Moligand™

Tipo de ação

AGONIST

Mecanismo de ação

Progesterone receptor agonist

Propriedades do produto

ALogP

3.9

Nomes e identificadores

SMILES isoméricas

CC(=O)O[C@H]1CC[C@@H]2[C@H]3CC[C@]4([C@H]([C@@H]3CCC2=C1)CC[C@]4(C#C)OC(=O)C)C

WGK Alemanha

3

RTECS

RC8963000

Peso molecular

384.51

Reaxy-Rn

2678817

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2678817&ln=

Propriedades químicas e físicas

• Solubilidade: Solubility (25°C) In vitro DMSO: 30 mg/mL (195.89 mM); Water: Insoluble; Ethanol: Insoluble
• Rotação específica [α]: -72° (C=1,CHCl3)
• Ponto de fusão (°C): 130 °C