Evifacotrep - ≥99% , CAS No.2413739-88-3

CAS: 2413739-88-3 Cat. No.: E650146 Fórmula: C₁₈H₁₂ClF₄N₅O₂ Peso molecular: 441.77 PubChem CID: 146448026

GRAU & PUREZA ≥99%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Visão geral

Evifacotrep, a short transient receptor potential channel 5 and 4 ( TRPC5 / TRPC4 ) antagonist (WO2020061162, compound 100), can be used for the research of neurological diseases. Evifacotrep targets to TRPC5 / TRPC4 with IC 50 s ≤50 nM

In Vitro

Evifacotrep (1 μM; 24 h) inhibits cell growth in ICLN-1694 cells(HEK-TRExhTRPC4). MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Evifacotrep (30 mg/kg; sc; once daily or twice daily for 10 days) results in reduced urinary albumin excretion on following injury with puromycinaminonucleoside (PAN) . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:TRPC5

Especificações

Especificações e pureza

≥99%

Mecanismos bioquímicos e fisiológicos

Evifacotrep, a short transient receptor potential channel 5 and 4 ( TRPC5 / TRPC4 ) antagonist (WO2020061162, compound 100), can be used for the research of neurological diseases. Evifacotrep targets to TRPC5 / TRPC4 with IC 50 s ≤50 nM.

Condições de armazenamento de armazenamento

Store at -20°C

Enviado em

Ice chest + Ice pads

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Tipo de ação

ANTAGONIST

Pureza

≥99%

Nomes e identificadores

SMILES isoméricas

C1CN(CC2=C1C(=NC=N2)OC3=C(C=C(C=C3)F)C(F)(F)F)C4=C(C(=O)NN=C4)Cl

PubChem CID

146448026

Peso molecular

441.77

Mecanismos de ação

Propriedades químicas e físicas

• Solubilidade: DMSO : 50 mg/mL (113.18 mM; ultrasonic and warming and heat to 60°C)
• Peso molecular: 441.800 g/mol
• XLogP3: 3.100
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 10
• Rotatable Bond Count: 3
• Exact Mass: 441.062 Da
• Monoisotopic Mass: 441.062 Da
• Topological Polar Surface Area: 79.700 Ų
• Heavy Atom Count: 30
• Formal Charge: 0
• Complexity: 734.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Perguntas frequentes

What is the purity of this product?

This product is supplied at ≥99% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2413739-88-3, the molecular formula is C18H12ClF4N5O2, and the molecular weight is 441.77 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.