(±)-Evodiamina - ≥98% , CAS No.518-18-3

Name: (±)-Evodiamina - ≥98% , CAS No.518-18-3
SKU: E140884
Availability: InStock

CAS: 518-18-3 Cat. No.: E140884 Fórmula: C₁₉H₁₇N₃O Peso molecular: 303.37

COA

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(±)-Evodiamina - ≥98% CAS No(518-18-3) by Aladdin Scientific

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Disponível para encomenda

GRADE & PURITY ≥98%

Synonyms

XE178590 | AS-15078 | HY-N0114A | NCGC00163553-02 | SureCN682158 | FT-0651829 | Evodiamina, Evodia rutaecarpa | NSC258314 | NSC-258314 | Evodiamina; | NCGC00163553-03 | Q5418554 | PubChem18244 | (1S)-21-metil-3,13,21-triazapentaciclo[11.8.0.0^{2,10.0^{4,

Storage

Armazenar a 2-8°C

Shipped In

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Visão geral Specifications Nomes e identificadores Documentation Advanced Data Taxonomic Classification Estrutura 3D Alvos associados (humanos) Alvos associados (não humanos) Mecanismos de ação Certificados（CoA,COO,BSE/TSE e Mapa de Análise) Propriedades químicas e físicas FAQs e artigos Calculadoras de soluções Revisões Perguntas frequentes

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Why this grade

≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Armazenar a 2-8°C Ships Gelo húmido Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Visão geral

A evodiamina é um alcaloide quinozole isolado da Evodia rutaecarpa, descrito como um agonista do VR1 (recetor vanilóide subtipo 1, TRPV1) com afinidade (Ki = 5,95 microM) comparável à do ativador químico prototípico do VR1, a capsaicina.A indução da captação de 45Ca2+ pela evodiamina foi antagonizada de forma competitiva pelo antagonista da capsaicina, a capsazepina. Está descrito que a evodiamina inibe a síntese de prostaglandina E2, a indução da ciclo-oxigenase-2 e a ativação do NF-κB, produzindo efeitos anti-inflamatórios.
Agonista antiangiogénico e anti-inflamatório do TRPV1.

Specifications

Sinónimos

Especificações e pureza

≥98%

Mecanismos bioquímicos e fisiológicos

O sinal de ativação do interferão-γ que regula a ativação transcricional do gene da iNOS é bloqueado pela evodiamina, suprimindo a síntese da proteína iNOS, mas sem afetar a função da iNOS. A evodiamina também demonstra antiangiogénese através da inibição

Condições de armazenamento de armazenamento

Armazenar a 2-8°C

Enviado em

Gelo húmido

Tipo de ação

INHIBITOR

Pureza

≥98%

Nomes e identificadores

Pubchem Sid

504757359

Pubchem Sid Url

https://pubchem.ncbi.nlm.nih.gov/substance/504757359

Sorrisos canónicos

CN1C2C3=C(CCN2C(=O)C4=CC=CC=C41)C5=CC=CC=C5N3

IUPAC Name

21-methyl-3,13,21-triazapentacyclo[11.8.0.02,10.04,9.015,20]henicosa-2(10),4,6,8,15,17,19-heptaen-14-one

InChIKey

TXDUTHBFYKGSAH-UHFFFAOYSA-N

INCHI

1S/C19H17N3O/c1-21-16-9-5-3-7-14(16)19(23)22-11-10-13-12-6-2-4-8-15(12)20-17(13)18(21)22/h2-9,18,20H,10-11H2,1H3

SMILES isoméricas

CN1C2C3=C(CCN2C(=O)C4=CC=CC=C41)C5=CC=CC=C5N3

Peso molecular

303.37

Reaxy-Rn

94484

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=94484&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

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📊 Datasheet

Quick-reference summary of product specifications and applications.

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🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

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Advanced Data

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Classe Indoles and derivatives
    - Subclass Pyridoindoles

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Classe	Indoles and derivatives
Subclass	Pyridoindoles
Intermediate Tree Nodes	Not available
Direct Parent	Beta carbolines
Alternative Parents	Quinazolines 3-alkylindoles Dialkylarylamines Benzenoids Vinylogous amides Tertiary carboxylic acid amides Pyrroles Heteroaromatic compounds Lactams Azacyclic compounds Organopnictogen compounds Organooxygen compounds Organic oxides Hydrocarbon derivatives
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	Beta-carboline - Diazanaphthalene - Quinazoline - 3-alkylindole - Indole - Dialkylarylamine - Benzenoid - Pyrrole - Tertiary carboxylic acid amide - Vinylogous amide - Heteroaromatic compound - Lactam - Carboxamide group - Carboxylic acid derivative - Azacycle - Organic oxide - Organic nitrogen compound - Organopnictogen compound - Organooxygen compound - Organonitrogen compound - Organic oxygen compound - Hydrocarbon derivative - Aromatic heteropolycyclic compound
Descrição	This compound belongs to the class of organic compounds known as beta carbolines. These are compounds containing a 9H-pyrido[3,4-b]indole moiety.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Estrutura 3D

Alvos associados (humanos)

PDE5A Tclin Phosphodiesterase 5A (5113 Activities)

Discover Target: PDE5A

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TOP1 Tclin DNA topoisomerase I (7553 Activities)

Discover Target: TOP1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TOP2A Tclin DNA topoisomerase II alpha (6317 Activities)

Discover Target: TOP2A

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ACHE Tclin Acetylcholinesterase (18204 Activities)

Discover Target: ACHE

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PPARG Tclin Peroxisome proliferator-activated receptor gamma (15191 Activities)

Discover Target: PPARG

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

RXRA Tclin Retinoid X receptor alpha (3637 Activities)

Discover Target: RXRA

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TRPV1 Tclin Vanilloid receptor (8273 Activities)

Discover Target: TRPV1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Caco-2 (12174 Activities)

Lot Number	Certificate Type	Data	Item
L2115509	Certificate of Analysis	Sep 17, 2025	E140884
L2115569	Certificate of Analysis	Sep 17, 2025	E140884
L2115598	Certificate of Analysis	Sep 17, 2025	E140884
I2123148	Certificate of Analysis	Jul 10, 2025	E140884
I2123149	Certificate of Analysis	Jul 10, 2025	E140884
I2123150	Certificate of Analysis	Jul 10, 2025	E140884
L2021230	Certificate of Analysis	Oct 12, 2024	E140884
C1624049	Certificate of Analysis	Oct 09, 2023	E140884

Solubilidade	Soluble in DMSO (5 mg/mL,warm to 40°C), water (<1 mg/mL) at 25 °C, and ethanol (<1 mg/mL) at 25 °C
Sensibilidade	Light sensitive.
Ponto de fusão (°C)	272°C(lit.)
Peso molecular	303.400 g/mol
XLogP3	3.100
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	0
Exact Mass	303.137 Da
Monoisotopic Mass	303.137 Da
Topological Polar Surface Area	39.300 Å²
Heavy Atom Count	23
Formal Charge	0
Complexity	495.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

(±)-Evodiamina - ≥98% , CAS No.518-18-3

Storage & shipping

Quality documents

Literature proof

Visão geral

Specifications

Documentation

📋 Safety Data Sheet (SDS)

✅ Certificate of Analysis (COA)

📊 Datasheet

🔬 Specification Sheet

Advanced Data

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

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Perguntas frequentes

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