≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at 2-8°C,Protected from light Ships Wet ice Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
EWP 815 is a disulfiram analogue, is a potent inhibitor of Ins(1,4) P 2 phosphatase and Ins(1,4,5) P 3 5-phosphatase . EWP 815 also inhibits enzyme dopamine β-hydroxylase activity
In Vitro
EWP 815 inhibits thyrotropin-releasing hormone (TRH; 0.03 mM)-stimulated inositol phospholipid breakdown without affecting basal breakdown rates in prelabelled GH 3 cells with IC 50 s of 83 mM (soluble enzymes) and 71 mM (particulate enzymes), respectively. EWP 815 (30 μM; 1 h) exerts higher inhibition on Ins(1,4) P 2 phosphatase rather than Ins(1,4,5) P 3 5-phosphatase with the mean [ 3 H]Ins(1,4) P 2 /mean [ 3 H]Ins P recovery ratio of 2.6. EWP 815 (6, 8 μM; 10 min) inhibits dephosphorylation of [ 3 H]Ins(1,4,5) P 3 5-phosphatase in particulate and soluble fractions with IC 50 s of 6 μM and 8 μM, respectively. EWP 815 (3-300 μM; 30 min) suppresses thyrotropin-releasing hormone (TRH)-stimulated (100 nM) inositol phospholipid production by 30% (100 μM) and 1.8% (300 μM), respectively, without affecting Ins(1,4,5) P 3 binding. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
EWP 815 (50 mg/kg; i.p.; 30 min before killed) inhibits the enzyme dopamine β-hydroxylase activity in mice. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Female mice (20 g)Dosage: 50 mg/kg Administration: Intraperitoneal injection; 30 min before killed Result: Intraperitoneal injection; 30 min before killedInhibited β-hydroxylase of 3 H-α-methyldopamine. Reduced the amount of 3 H-α-Me-NA by 12%.
Form:Solid
IC50& Target:Ins(1,4)P2 phosphatase,Ins(1,4,5)P3 5-phosphatase, ,dopamine β-hydroxylase
| SMILES isoméricas | CN1CCN(CC1)C(=S)SSC(=S)N2CCN(CC2)C |
|---|---|
| PubChem CID | 30054 |
| Peso molecular | 350.59 |
Comprehensive hazard, handling, storage, and regulatory compliance document.
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View spec sheet →| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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| Solubilidade | DMSO : 50 mg/mL (142.62 mM; Need ultrasonic) |
|---|---|
| Peso molecular | 350.600 g/mol |
| XLogP3 | 1.300 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 6 |
| Rotatable Bond Count | 3 |
| Exact Mass | 350.073 Da |
| Monoisotopic Mass | 350.073 Da |
| Topological Polar Surface Area | 128.000 Ų |
| Heavy Atom Count | 20 |
| Formal Charge | 0 |
| Complexity | 315.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
