Experiments on the effect of different routes of administration on drug action
In pharmacology experiments, there are many factors affecting the experimental results, some of which can be controlled, while some are difficult to control. In
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Experimental prevention of barium chloride-induced arrhythmias by propranolol and quinidine
Barium chloride induces arrhythmias by increasing the inward Na+ current in Purkinje fibers and increasing the depolarization rate of the maximal diastolic pote
Experiments on the relationship between solubility and action of barium salts
Solubility-action relationship experiments with barium salts can be used to study the effect of the physicochemical properties of a drug on its action.
Experiments on the observation of the inhibitory and excitatory effects of drugs on respiration
High-dose injections of aminoglycoside antibiotics can produce a blockade of the muscle junction, which is manifested by weakness of the extremities. Dyspnea or
Experimental methods for the determination of blood concentration and calculation of pharmacokinetic parameters of sulfonamides
Sulfonamides and compounds with free amino groups on the benzene ring undergo diazotization with sodium nitrite in acidic solutions to produce diazonium salts,
Experimental determination of LD50
The lethal dose (LD50) is an indication of the level of toxicity of drugs, poisons and pathogenic microorganisms. It represents the dose or concentration that k
Observation experiment on the diuretic effect of drugs
NA is an a receptor agonist, a larger dose can constrict renal blood vessels, reduce renal blood flow, resulting in a decrease in urine output; furosemide is a
Experimental determination of plasma half-life and apparent volume of distribution of drugs
In pharmacology experiments, there are many factors affecting the experimental results, some of which can be controlled, while some are difficult to control. In
Experimental effects of drugs on blood pressure and heart rhythm in rabbits
Epinephrine alone has a pressor effect, while alpha-blockers can reverse its pressor effect. Barium chloride can promote the inward flow of sodium ions in the P