Tag: 3,3-disubstituted oxetane | Aladdin Scientific
Articles by tag "3,3-disubstituted oxetane"
- Design Logic of Fluorinated 3,3-Disubstituted Oxetane Building Blocks: Structural Construction and Modulation of Amine Basicity, Lipophilicity, and Metabolic Stability Introduction Lead compound optimization usually requires the simultaneous modulation of target activity, solubility, membrane permeability, metabolic stability, and nonspecific binding. A structural change may improve one property while shifting another outside the desired range. For ...