DNA damage

How RNA-DNA Hybrids Affect Genome Stability: RNase H1, RNase H2, and R-loop Regulatory Mechanisms

RNA-DNA hybrids are nucleic acid structures formed by pairing between an RNA strand and a DNA template strand. Typical forms include transcription-associated R-loops and hybrid regions formed after ribonucleotides are incorporated into DNA. RNase H1, RNase H2, helicases, topoisomerases, and ...