1,700+ technical articles by Aladdin Scientific's scientists on reagent selection, reaction mechanisms, assay design and formulation. New every week.
Biomimetic peptides used as skincare ingredients are typically synthetic peptides designed on the basis of natural human proteins, extracellular matrix fragments, receptor ligands, or protein–protein interaction regions. Through specific amino acid sequences and spatial conformations, they ...
Sodium hyaluronate, crosslinked sodium hyaluronate polymers, sodium acetylated hyaluronate, and hydrolyzed sodium hyaluronate frequently appear together in moisturizing skincare products. They all retain the repeating disaccharide backbone of hyaluronic acid, but differ in molecular chain ...
Skin hydration depends not only on the amount of moisturizing ingredients applied to the skin, but also on the ability of the epidermis to limit outward water diffusion and the capacity of corneocytes to continuously bind and retain water. Tight junctions, keratinocyte differentiation, stratum ...
Tremella fuciformis polysaccharides may be present in the fruiting bodies, mycelia, spore cultures, and submerged fermentation systems of Tremella fuciformis. Raw materials for skincare applications are usually obtained through aqueous extraction of fruiting bodies or microbial submerged ...
Introducing fluorinated groups into organic molecules generally requires simultaneous consideration of three questions: whether the fluorinated fragment can be conveniently prepared and stored, whether a new chemical bond can be formed at the intended position, and whether the reaction product ...
The 3C-like protease (3CL^pro), also known as the main protease (M^pro), is responsible for cleaving pp1a and pp1ab at 11 sites, thereby contributing to the release of the nonstructural proteins required for viral replication. Inhibition of 3CL^pro reduces the production of mature nonstructural ...
Non-small cell lung cancer exhibits substantial histological and molecular heterogeneity. Alterations involving EGFR, ALK, ROS1, KRAS, BRAF, RET, MET, HER2, and other oncogenic drivers can continuously activate tumor-cell proliferation and survival signaling and generate molecular subtypes with ...
Uric acid is the major end product of purine catabolism in humans and exists primarily as free uric acid or urate in blood, urine, and tissues. Uric acid quantification is a commonly used technique in clinical biochemical analysis and metabolic research and is widely applied in hyperuricemia ...
Protein kinases and phosphatases jointly regulate the phosphorylation states of proteins, thereby affecting cellular signaling, metabolism, proliferation, and stress responses. Phosphorylation or dephosphorylation does not directly equate to protein activation or inactivation, and its effect ...