1,700+ technical articles by Aladdin Scientific's scientists on reagent selection, reaction mechanisms, assay design and formulation. New every week.
Stable isotope-labeled compounds use ²H, ¹³C, ¹⁵N, or ¹⁸O to label metabolic substrates, allowing their transformation and fate in vivo to be identified by mass spectrometry or nuclear magnetic resonance. This technology can be used to determine substrate sources, metabolic pathways, ...
Necrosis by sodium overload (NECSO) is a form of necrotic cell death caused by sustained activation of transient receptor potential melastatin 4 (TRPM4). It is characterized by massive Na⁺ influx, membrane depolarization, osmotic imbalance, and cellular swelling and is accompanied by ...
Histone methylation is an important epigenetic mechanism that regulates chromatin states and gene expression. Different modification sites and degrees of methylation produce distinct transcriptional effects, and their dysregulation is closely associated with tumorigenesis, impaired cell ...
Mitochondria maintain the energy supply, biosynthesis, and redox homeostasis of tumor cells through oxidative phosphorylation, the TCA cycle, and substrate oxidation. Certain tumors and treatment-persistent cells can develop specific mitochondrial metabolic dependencies, making OXPHOS, substrate ...
High microsatellite instability (microsatellite instability-high, MSI-H) is a genomic phenotype resulting from defective DNA mismatch repair. The continuous accumulation of insertion–deletion mutations generates frameshift neoantigens that increase tumor immune visibility while also producing ...
Sirtuins are a family of NAD⁺-dependent deacylases comprising SIRT1–7 and are involved in metabolism, DNA repair, mitochondrial homeostasis, and inflammatory regulation. Animal studies suggest that certain members may improve healthspan, but there is currently no direct evidence that they ...
In amyotrophic lateral sclerosis, abnormally accumulated TDP-43 can damage mitochondria and promote the release of mitochondrial DNA into the cytoplasm. After recognizing this abnormal DNA, cGAS generates 2′,3′-cGAMP and activates STING, subsequently initiating TBK1–IRF3 and NF-κB ...
Dietary restriction, Rapamycin, α-ketoglutarate (AKG), and Carglumic Acid influence aging-related processes through nutrient availability, mTOR signaling, central metabolism, and nitrogen metabolism, respectively. Their effects involve autophagy, proteostasis, mitochondrial function, and ...
4-Hydroxycoumarin is a derivative formed by introducing a hydroxyl group at C4 of the α-pyrone ring of coumarin. Its systematic name is 4-hydroxy-2H-chromen-2-one. Its C4 hydroxyl group differs from an ordinary phenolic hydroxyl group on the benzene ring. In the predominant ...
