1,700+ technical articles by Aladdin Scientific's scientists on reagent selection, reaction mechanisms, assay design and formulation. New every week.
Classical PROTACs rely on E3 ubiquitin ligases and the proteasome to eliminate intracellular target proteins, but they are difficult to apply to extracellular proteins, large-scale cellular components, and bacterial proteins. LYTAC, ATTEC, AUTAC, and BacPROTAC respectively utilize ...
Necroptosis is a form of regulated cell death centered on the RIPK3–MLKL execution axis. Plasma membrane rupture can be accompanied by the release of DAMPs, tumor antigens, and inflammatory signals, thereby directly linking cell death to changes in the tumor immune microenvironment. ...
Amino acid dehydrogenases catalyze oxidative deamination or reductive amination between amino acids and their corresponding α-keto acids. Through NAD(H), NADP(H), or flavin cofactors, these enzymes connect nitrogen metabolism, central carbon metabolism, and cellular redox status. They are also ...
Defensins are cysteine-rich cationic antimicrobial peptides produced primarily by neutrophils, intestinal Paneth cells, and various mucosal epithelial cells. They can directly disrupt microbial membranes, entrap pathogens, recruit immune cells, and regulate the mucosal microbiota, making them ...
Urinary protein composition is jointly determined by plasma filtration, tubular reabsorption, active secretion by the nephron, and protein release from injured epithelial cells. Different proteins correspond to distinct nephron segments and pathological processes and can therefore be used to ...
The aromatic ring provides the C6 portion, while the —CH=CH–COOH side chain constitutes the C3 portion. The C=C double bond lies between the aromatic ring and the carboxyl group, giving the side chain a continuous Ar–C=C–C=O conjugated structure.
The phenylpropanoid alcohols and aldehydes discussed in this article mainly refer to cinnamyl alcohol, cinnamaldehyde, and their oxygenated aromatic-ring derivatives, which contain Ar–CH=CH–CH₂OH and Ar–CH=CH–CHO side chains, respectively. These two classes of compounds share the same ...
Simple phenylpropanoids generally have a C6–C3 unit, composed of a six-carbon aromatic ring and a three-carbon side chain, as their basic structure. In plants, these structures are derived mainly from the phenylpropanoid metabolic pathway and share a common biogenetic origin with ...
In the traditional classification used in natural products chemistry, anthracene derivatives are generally divided into monomeric and dimeric anthracene derivatives. Dimeric anthracene derivatives include dianthrones, bianthraquinones, dehydrodianthrones, helianthrones, and highly fused ...
