1,700+ technical articles by Aladdin Scientific's scientists on reagent selection, reaction mechanisms, assay design and formulation. New every week.
Growth Hormone (GH) is an important peptide hormone secreted by the anterior pituitary. Through GHR–JAK2–STAT5 signaling and the GH–IGF-1 axis, it regulates linear growth, skeletal and muscle development, lipid mobilization, and glucose metabolism. GH research requires simultaneous ...
MC4R is a core receptor in the hypothalamic melanocortin energy-homeostasis pathway and directly connects Leptin–POMC–α-MSH signaling with food intake, hunger, and energy expenditure. Unlike conventional weight-loss drugs, the distinctive value of MC4R agonism lies in restoring impaired ...
Activin E encoded by INHBE is mainly produced by the liver and regulates lipid storage and lipolysis through ALK7/ACVR1C in adipocytes. Reducing INHBE or ALK7 signaling can promote fat mobilization and alter fat distribution, making this liver–adipose tissue endocrine axis an emerging fat-loss ...
ActRIIA and ActRIIB are important receptors for TGF-β superfamily ligands such as Myostatin/GDF8 and Activin A. Through SMAD2/3 signaling, they restrict skeletal muscle growth and participate in adipose tissue metabolism. Blocking ActRIIA/ActRIIB can increase or preserve Lean Mass while ...
Plant culture media provide inorganic salts, carbon sources, vitamins, and a plant growth-regulatory environment for isolated tissues, and their composition directly affects cell proliferation, callus formation, organogenesis, and rooting. In research applications, basal systems such as MS, B5, ...
Oligopeptides are short-chain peptides formed by a small number of amino acid residues linked through peptide bonds. According to biochemical nomenclature materials from the International Union of Pure and Applied Chemistry (IUPAC), peptides containing fewer than approximately 10–20 amino acid ...
Amylin is a postprandial metabolic hormone co-secreted with Insulin by pancreatic β cells. It limits continuous nutrient influx by promoting meal termination, delaying gastric emptying, and regulating prandial Glucagon secretion. The Amylin receptor is not a single receptor protein but a ...
Type 2 diabetes, obesity, and related metabolic diseases all involve abnormalities in glucose homeostasis, pancreatic endocrine function, food intake, and energy balance. GLP-1R can simultaneously regulate insulin secretion, glucagon, gastric emptying, and feeding behavior and has therefore ...
Obesity and related metabolic diseases are characterized not only by increased energy intake and fat storage but also by abnormalities in hepatic glucose and lipid metabolism, substrate utilization, and amino acid homeostasis. GCGR is an important Class B1 GPCR that regulates hepatic substrate ...
