Determine the necessary mass, volume, or concentration for preparing a solution.
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Moligand™, ≥98% Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 20 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
A hypolipidemic PPARα agonist.
Fenofibrate has been used:
• to study its effect on plasma lipids, liver phenotype and gene expression;
• to study its impact on endothelium-dependent vasodilatation of thoracic aorta;
• to administer to NASH knock-in mice along with a high fat diet (HFD) to study its effect
| ALogP | 5.2 |
|---|
| Pubchem Sid | 504750661 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/504750661 |
| Canonical Smiles | CC(C)OC(=O)C(C)(C)OC1=CC=C(C=C1)C(=O)C2=CC=C(C=C2)Cl |
| IUPAC Name | propan-2-yl 2-[4-(4-chlorobenzoyl)phenoxy]-2-methylpropanoate |
| InChIKey | YMTINGFKWWXKFG-UHFFFAOYSA-N |
| INCHI | 1S/C20H21ClO4/c1-13(2)24-19(23)20(3,4)25-17-11-7-15(8-12-17)18(22)14-5-9-16(21)10-6-14/h5-13H,1-4H3 |
| Isomeric SMILES | CC(C)OC(=O)C(C)(C)OC1=CC=C(C=C1)C(=O)C2=CC=C(C=C2)Cl |
| WGK Germany | 3 |
| RTECS | UA2453400 |
| Molecular Weight | 360.83 |
| Reaxy-Rn | 2062462 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2062462&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Benzenoids |
| Class | Benzene and substituted derivatives |
| Subclass | Benzophenones |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Benzophenones |
| Alternative Parents | Diphenylmethanes Aryl-phenylketones Phenoxyacetic acid derivatives Phenoxy compounds Phenol ethers Benzoyl derivatives Chlorobenzenes Alkyl aryl ethers Aryl chlorides Carboxylic acid esters Monocarboxylic acids and derivatives Organochlorides Organic oxides Hydrocarbon derivatives |
| Molecular Framework | Aromatic homomonocyclic compounds |
| Substituents | Benzophenone - Aryl-phenylketone - Diphenylmethane - Phenoxyacetate - Phenoxy compound - Aryl ketone - Phenol ether - Benzoyl - Alkyl aryl ether - Chlorobenzene - Halobenzene - Aryl chloride - Aryl halide - Carboxylic acid ester - Ketone - Monocarboxylic acid or derivatives - Carboxylic acid derivative - Ether - Organohalogen compound - Organic oxygen compound - Carbonyl group - Organochloride - Organooxygen compound - Hydrocarbon derivative - Organic oxide - Aromatic homomonocyclic compound |
| Description | This compound belongs to the class of organic compounds known as benzophenones. These are organic compounds containing a ketone attached to two phenyl groups. |
| External Descriptors | aromatic ether - carboxylic ester - monochlorobenzenes - chlorobenzophenone |
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Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
| Certificate of Analysis | May 16, 2026 | F129682 | |
| Certificate of Analysis | May 16, 2026 | F129682 | |
| Certificate of Analysis | Mar 11, 2026 | F129682 | |
| Certificate of Analysis | Mar 11, 2026 | F129682 | |
| Certificate of Analysis | Mar 11, 2026 | F129682 | |
| Certificate of Analysis | Jan 19, 2026 | F129682 | |
| Certificate of Analysis | Nov 20, 2025 | F129682 | |
| Certificate of Analysis | Nov 20, 2025 | F129682 | |
| Certificate of Analysis | Nov 20, 2025 | F129682 | |
| Certificate of Analysis | Jun 28, 2024 | F129682 | |
| Certificate of Analysis | Jun 28, 2024 | F129682 | |
| Certificate of Analysis | Sep 15, 2023 | F129682 | |
| Certificate of Analysis | Jul 16, 2022 | F129682 | |
| Certificate of Analysis | Jul 16, 2022 | F129682 | |
| Certificate of Analysis | Jul 16, 2022 | F129682 | |
| Certificate of Analysis | Jul 16, 2022 | F129682 | |
| Certificate of Analysis | Jul 16, 2022 | F129682 | |
| Certificate of Analysis | Jul 16, 2022 | F129682 | |
| Certificate of Analysis | Jun 15, 2022 | F129682 |
| Solubility | Soluble in acetone, ether, DMSO (15 mg/ml), DMF (30 mg/ml), ethanol (1 mg/ml), methanol (slightly soluble), benzene, chloroform, DMF:PBS (1:3 pH 7.2) (0.25 mg/ml), ethyl acetate, acetonitrile, and hexane. Insoluble in water. |
|---|---|
| Melt Point(°C) | 81°C |
| Molecular Weight | 360.800 g/mol |
| XLogP3 | 5.200 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 4 |
| Rotatable Bond Count | 7 |
| Exact Mass | 360.113 Da |
| Monoisotopic Mass | 360.113 Da |
| Topological Polar Surface Area | 52.600 Ų |
| Heavy Atom Count | 25 |
| Formal Charge | 0 |
| Complexity | 458.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
| 1. Zhang Li, Tong Yingying, Fang Yan, Pei Jinjin, Wang Qilan, Li Gang. (2023) Exploring the hypolipidemic effects of bergenin from Saxifraga melanocentra Franch: mechanistic insights and potential for hyperlipidemia treatment. Lipids in Health and Disease, 22 (1): (1-16). [PMID:38001454] [10.1186/s12944-023-01973-2] |
| 2. Xueyun Liu, Man Hu, Chen Ye, Lihong Liao, Chang Ding, Lijuan Sun, Jichao Liang, Yong Chen. (2022) Isosilybin regulates lipogenesis and fatty acid oxidation via the AMPK/SREBP-1c/PPARα pathway. CHEMICO-BIOLOGICAL INTERACTIONS, [PMID:36347319] [10.1016/j.cbi.2022.110250] |
| 3. Sa Yang, Shijie Cao, Congyu Li, Jichao Zhang, Chang Liu, Feng Qiu, Ning Kang. (2022) Berberrubine, a Main Metabolite of Berberine, Alleviates Non-Alcoholic Fatty Liver Disease via Modulating Glucose and Lipid Metabolism and Restoring Gut Microbiota. Frontiers in Pharmacology, [PMID:35873595] [10.3389/fphar.2022.913378] |
| 4. Miaomiao Chi, Kunming Qin, Lei Cao, Min Zhang, Yingying Su, Xun Gao. (2022) Surface Functionalized Magnetic Nanoparticles as a Selective Sorbent for Affinity Fishing of PPAR-γ Ligands from Choerospondias axillaris. MOLECULES, 27 (10): (3127). [PMID:35630609] [10.3390/molecules27103127] |
| 5. Qin Yeyu, Xie Jing, Zheng Ruihe, Li Yuhang, Wang Haixia. (2022) Oleoylethanolamide as a New Therapeutic Strategy to Alleviate Doxorubicin-Induced Cardiotoxicity. Frontiers in Pharmacology, [PMID:35517792] [10.3389/fphar.2022.863322] |
| 6. Yan-Yu Zhang, Jun-Xian Wang, Jiong Ren, Jie Wang, Fang Qiao, Mei-Ling Zhang, Zhen-Yu Du. (2021) Activation of peroxisome proliferator-activated receptor-α stimulated lipid catabolism in liver of largemouth bass, Micropterus salmoides. AQUACULTURE NUTRITION, 27 (6): (2749-2758). [PMID:] [10.1111/anu.13400] |
| 7. Emmanuel Omari-Siaw, Qilong Wang, Congyong Sun, Zengquan Gu, Yuan Zhu, Xia Cao, Caleb Kesse Firempong, Rita Agyare, Ximing Xu, Jiangnan Yu. (2016) Tissue distribution and enhanced in vivo anti-hyperlipidemic-antioxidant effects of perillaldehyde-loaded liposomal nanoformulation against Poloxamer 407-induced hyperlipidemia. INTERNATIONAL JOURNAL OF PHARMACEUTICS, [PMID:27567929] [10.1016/j.ijpharm.2016.08.042] |
| 8. Shuyu Li, Di Wu, Hui Yu, Xin Huang, Na Wang, Ting Wang, Hongxun Hao. (2025) A novel energy-efficient way to prepare solid lipid microspheres loaded with nanoscale drugs by combining LLPS and in-situ crystallization. Particuology, [PMID:] [10.1016/j.partic.2025.03.015] |
| 9. Shengzheng Guo, Yuechao Cao, Yuxin Zhang, Yan Wang, Zhenguo Gao, Junbo Gong. (2024) A Scalable Freeze-Dissolving Approach to Prepare Ultrafine Crystals for Inhalation: Mechanism and Validation. CRYSTAL GROWTH & DESIGN, [PMID:] [10.1021/acs.cgd.4c00018] |
| 10. Haotian Zhang, Xiaoying Chen, Hua Rong, Baojia Chen, Junfeng Guang, Qing Pan, Xiaobo Wen, Lijun Ning. (2025) Indispensable role of PGC1α signaling in lipid and carbohydrate metabolism of fish PPARα activation. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, [PMID:40049462] [10.1016/j.ijbiomac.2025.141722] |
| 11. Shuyu Li, Di Wu, Hui Yu, Xin Huang, Na Wang, Ting Wang, Hongxun Hao. (2025) Low-Temperature Liquid–Liquid Phase Separation Strategy for In Situ Preparation of Porous Solid Lipid Microspheres Loaded with Fenofibrate Nanocrystals. CRYSTAL GROWTH & DESIGN, [PMID:] [10.1021/acs.cgd.4c01580] |
| 12. Yang Yu Mei, Ma Hang Bin, Xiong Yue, Wu Qian, Gao Xiu Kui. (2025) PEX11B palmitoylation couples peroxisomal dysfunction with Schwann cells fail in diabetic neuropathy. JOURNAL OF BIOMEDICAL SCIENCE, 32 (1): (1-17). [PMID:39934809] [10.1186/s12929-024-01115-5] |
| 13. Wanhao Qi, Jinghao Chen, Shiqiao Rui, Shi Li, Yiduo Ding, Shuaipeng Feng, Zhu Liu, Qiwei Liu, Siling Wang, Qinfu Zhao. (2025) Variable pore size of mesoporous silica in improving physical stability and oral bioavailability of insoluble drugs. INTERNATIONAL JOURNAL OF PHARMACEUTICS, [PMID:40010525] [10.1016/j.ijpharm.2025.125394] |
| 14. Qianyu Wu, Yu Zhang, Ce Sun, Jun Dang. (2025) Online bioactivity-guided HPLC-lipoprotein lipase system with medium-high pressure chromatography for rapid recognition and targeted isolation of natural affinity agents from Nitraria tangutorum. JOURNAL OF CHROMATOGRAPHY A, [PMID:40972433] [10.1016/j.chroma.2025.466384] |
| 15. Lu Tianshu, Wu Yiyang, Xiong Ping, Zhong Hao, Ding Yang, Li Haifeng, Ouyang Defang. (2025) Combining High-Throughput Screening and Machine Learning to Predict the Formation of Both Binary and Ternary Amorphous Solid Dispersion Formulations for Early Drug Discovery and Development. PHARMACEUTICAL RESEARCH, [PMID:40180767] [10.1007/s11095-025-03853-z] |
| 16. Mingtian Tian, Jiahong Dong, Yuhong Guo, Yihe Zhao, Jianxin Cao. (2025) Beneficial effects of soluble dietary fiber from Dendrocalamus brandisii Munro shoots on high-fat diet-induced metabolic disorders in mice: impact on liver, adipose tissue, and intestinal health. Food Hydrocolloids for Health, [PMID:] [10.1016/j.fhfh.2025.100217] |
| 17. Jiayu Song, Huanhuan Zhang, Xiaohui Zhang, Meiying Liu, Dan Peng, Yuan Ren, Yan Sun, Yunlan Li. (2025) Galactose-modified erythrocyte membrane fusion liposomes enable the targeted delivery of drug nanoparticles to the liver. RSC Advances, 15 (22): (17781-17794). [PMID:40443690] [10.1039/D4RA07489K] |
| 18. Ming Chu, Yingying Tong, Lei Zhang, Yu Zhang, Jun Dang, Gang Li. (2025) Flavone C-Glycosides from Dianthus superbus L. Attenuate Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) via Multi-Pathway Regulations. Nutrients, 17 (15): (2456). [PMID:40806041] [10.3390/nu17152456] |
| 19. Man Wang, Yi Chen, Ming Guo, Pengzhi Xie, Xinzhe Zhao, Shulin Chen, Yian Deng, Rui Hu, Qianyi Wan, Juanyu Zhou, Zhuzhen Zhang, Ke Lan, Haiyang Chen, Yuan Liu. (2026) Impaired VLCFA-peroxisome-mediated intestinal epithelial repair causes gastrointestinal sequelae of long COVID. DEVELOPMENTAL CELL, [PMID:41494535] [10.1016/j.devcel.2025.12.003] |
| 20. Cong Zhang, Yingxi Luo, Yangkun Xiong, Liang Chen, Haixia Zhao, Zhenpeng Qiu, Yuan Yang. (2026) Gigantol Ameliorates Metabolic Dysfunction-Associated Steatohepatitis by Promoting TFEB-Mediated Lipophagy and Fatty Acid Oxidation. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, [PMID:41612154] [10.1021/acs.jafc.5c09366] |
Our grade selection guide covers purity, stabilizer status, and application suitability for all variants in our catalog.
View Moligand™ grade guide →