Fluocinonide - Moligand™, 10mM in DMSO , Glucocorticoid receptor agonist, CAS No.356-12-7, Glucocorticoid receptor agonist

CAS: 356-12-7 Cat. No.: F407947 Fórmula: C₂₆H₃₂F₂O₇ Peso molecular: 494.52 Número CE: 206-597-6

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

(6α,​11β,​16α)​-21-​(acetyloxy)​-​6,​9-​difluoro-​11-​hydroxy-​16,​17-​[(1-​methylethylidene)​bis(oxy)​]​-​pregna-​1,​4-​diene-​3,​20-​dione

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Visão geral

Information

Fluocinonide Fluocinonide (Vanos) is a potent glucocorticoid steroid used topically as anti-inflammatory agent for the treatment of skin disorders such as eczema.
In vitro

Fluocinonide cream has a lower potential to produce atrophic changes of the skin than either clobetasol cream or clobetasol propionate foam.

In vivo

Fluocinonide causes prompt and sustains pituitary-adrenocortical suppression in healthy dogs. Fluocinonide results in significant reduction of plasma cortisol and iACTH concentrations by day 2 of treatment in healthy dog, and the lower concentrations continued to day 5. One week after the last application of Fluocinonide, plasma iACTH concentrations in the corticosteroid-treated dogs has returned to the range of values for the control dogs; however, pre- and post-ACTH cortisol concentrations remains suppressed in Fluocinonide treated dogs. Two weeks after the last treatment, the pre-ACTH plasma cortisol concentrations of corticosteroid-treated dogs returns to those of the control dogs, but the post-ACTH plasma cortisol concentrations remains suppressed.
Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥98%

Specifications

Sinónimos

(6α,​11β,​16α)​-21-​(acetyloxy)​-​6,​9-​difluoro-​11-​hydroxy-​16,​17-​[(1-​methylethylidene)​bis(oxy)​]​-​pregna-​1,​4-​diene-​3,​20-​dione

Especificações e pureza

Moligand™, 10mM in DMSO

Mecanismos bioquímicos e fisiológicos

Fluocinonide (Vanos) is a potent glucocorticoid steroid used topically as anti-inflammatory agent for the treatment of skin disorders such as eczema.

Condições de armazenamento de armazenamento

Store at -80°C

Enviado em

Dry ice packs + Cold packs

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Grau

Moligand™

Tipo de ação

AGONIST

Mecanismo de ação

Glucocorticoid receptor agonist

Propriedades do produto

• ALogP: 3.2

Nomes e identificadores

• SMILES isoméricas: CC(=O)OCC(=O)[C@@]12[C@@H](C[C@@H]3[C@@]1(C[C@@H]([C@]4([C@H]3C[C@@H](C5=CC(=O)C=C[C@@]54C)F)F)O)C)OC(O2)(C)C
• WGK Alemanha: 3
• RTECS: TU3831000
• Peso molecular: 494.52
• Reaxy-Rn: 26095433
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=26095433&ln=

Alvos associados (humanos)

NR3C1 Tclin Glucocorticoid receptor (3 Activities)

Discover Target: NR3C1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Referências

1. Yanxia Li, Xiaoman Chen, Ling Xia, Xiaohua Xiao, Gongke Li.  (2019)  Magnetic metal-organic frameworks-101 functionalized with graphite-like carbon nitride for the efficient enrichment of glucocorticoids in cosmetics.  JOURNAL OF CHROMATOGRAPHY A,      [PMID:31353072] [10.1016/j.chroma.2019.460382]

Perguntas frequentes

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 356-12-7, the molecular formula is C26H32F2O7, and the molecular weight is 494.52 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.