Fluorescein - AR, ≥90% , CAS No.2321-07-5

CAS: 2321-07-5 Cat. No.: F100007 Fórmula: C₂₀H₁₂O₅ Peso molecular: 332.31 Número CE: 219-031-8

GRADE & PURITY AR, ≥90%

Synonyms

3',6'-Dihydroxyfluoran | C.I. Solvent Yellow 94 | Fluoresceine | Resorcinolphthalein | Solvent Yellow 94 | 3',6'-Dihydroxy-3H-spiro[isobenzofuran-1,9'-xanthen]-3-one | D&C Yellow No. 7 | fluorescein | Japan Yellow 201 | Yellow fluorescein | D and C Yellow

Storage

Room temperature

Shipped In

Normal

Visão geral

Fluorescein has been used:
in the permeability assay of Caco-2 cells
to test its suitability to serve as lifetime fluorescence standards
as a fluorophore for the fast recovery of fluorescence peaks and fluorophore concentration in the presence of hemoglobin
as a fluorescent probe in oxygen radical absorbance capacity (ORAC) assay

Specifications

Sinónimos

3',6'-Dihydroxyfluoran | C.I. Solvent Yellow 94 | Fluoresceine | Resorcinolphthalein | Solvent Yellow 94 | 3',6'-Dihydroxy-3H-spiro[isobenzofuran-1,9'-xanthen]-3-one | D&C Yellow No. 7 | fluorescein | Japan Yellow 201 | Yellow fluorescein | D and C Yellow

Especificações e pureza

AR, ≥90%

Aplicação

Fluorescein (free acid) has been used as a staining agent in retinal imaging. Fluorescein (free acid) is widely used as a fluorescent stain and trace for many living cells and tissue applications. It is also suitable as a marker for the study of motility

Condições de armazenamento de armazenamento

Room temperature

Enviado em

Normal

Grau

AR

Pureza

≥90%

Nomes e identificadores

Pubchem Sid

508816487

Pubchem Sid Url

https://pubchem.ncbi.nlm.nih.gov/substance/508816487

Sorrisos canónicos

C1=CC=C2C(=C1)C(=O)OC23C4=C(C=C(C=C4)O)OC5=C3C=CC(=C5)O

IUPAC Name

3',6'-dihydroxyspiro[2-benzofuran-3,9'-xanthene]-1-one

InChIKey

GNBHRKFJIUUOQI-UHFFFAOYSA-N

INCHI

1S/C20H12O5/c21-11-5-7-15-17(9-11)24-18-10-12(22)6-8-16(18)20(15)14-4-2-1-3-13(14)19(23)25-20/h1-10,21-22H

SMILES isoméricas

C1=CC=C2C(=C1)C(=O)OC23C4=C(C=C(C=C4)O)OC5=C3C=CC(=C5)O

Peso molecular

332.31

Reaxy-Rn

94324

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=94324&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Classe Benzopyrans
      • Subclass 1-benzopyrans
        • Level5 Dibenzopyrans
          • Level6 Xanthenes

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Classe: Benzopyrans
• Subclass: 1-benzopyrans
• Intermediate Tree Nodes: Dibenzopyrans
• Direct Parent: Xanthenes
• Alternative Parents: Diarylethers Phthalides Benzofuranones Isobenzofurans 1-hydroxy-2-unsubstituted benzenoids Lactones Carboxylic acid esters Oxacyclic compounds Monocarboxylic acids and derivatives Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Xanthene - Diaryl ether - Benzofuranone - Phthalide - Isobenzofuranone - Isobenzofuran - Isocoumaran - 1-hydroxy-2-unsubstituted benzenoid - Benzenoid - Lactone - Carboxylic acid ester - Oxacycle - Monocarboxylic acid or derivatives - Ether - Carboxylic acid derivative - Hydrocarbon derivative - Organic oxygen compound - Organooxygen compound - Organic oxide - Aromatic heteropolycyclic compound
• Descrição: This compound belongs to the class of organic compounds known as xanthenes. These are polycyclic aromatic compounds containing a xanthene moiety, which consists of two benzene rings joined to each other by a pyran ring.
• External Descriptors: xanthene dye - polyphenol - gamma-lactone

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Alvos associados (humanos)

FTO Tchem Alpha-ketoglutarate-dependent dioxygenase FTO (473 Activities)

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ALKBH5 Tchem RNA demethylase ALKBH5 (134 Activities)

Discover Target: ALKBH5

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Hdac6 Histone deacetylase 6 (222 Activities)

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rep Replicase polyprotein 1ab (378 Activities)

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surA Chaperone SurA (18 Activities)

Discover Target: surA

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SARS-CoV-2 (38078 Activities)

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Mecanismos de ação

Propriedades químicas e físicas

• Solubilidade: Slightly soluble in water and alcohol.
• Sensibilidade: Moisture sensitive.
• Ponto de fusão (°C): 314-316°C
• Peso molecular: 332.300 g/mol
• XLogP3: 3.400
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 0
• Exact Mass: 332.068 Da
• Monoisotopic Mass: 332.068 Da
• Topological Polar Surface Area: 76.000 Ų
• Heavy Atom Count: 25
• Formal Charge: 0
• Complexity: 522.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1