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Gal-(K)4, Agonist of GAL 1 receptor;Agonist of GAL 2 receptor, CAS No.rp174097, Agonist of GAL 1 receptor;Agonist of GAL 2 receptor

CAS: rp174097 Cat. No.: rp174097
COA
Gal-(K)4, Agonist of GAL 1 receptor;Agonist of GAL 2 receptor, CAS No.rp174097, Agonist of GAL 1 receptor;Agonist of GAL 2 receptor
Disponível para encomenda
GRAU & PUREZA Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools.
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Tamanho
Alemanha (EU)
USA*
Preço
Qtd
500μg
rp174097-500μg
Sob encomenda · 8–12 semanas
2082,49€
1mg
rp174097-1mg
Sob encomenda · 8–12 semanas
3470,87€
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SDS
Safety data
COA
Certificate
DS
Ficha técnica
SP
Folha de especificações
Especificações Armazenamento e envio Documentação Dados avançados Alvos associados (humanos) Certificados（CoA,COO,BSE/TSE e Mapa de Análise) Informação genética Calculadoras de soluções Revisões Perguntas frequentes Application Protocols Biological Roles Buffer Applications Green Alternatives Pharmaceutical Uses Physical Properties Quality and Grades Reaction and Applications Reaction Conditions Safety and Handling Solvent Selection Storage and Reconstitution Structure and Identity Synthetic Utility Target Specificity
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Por que este grau

Moligand™ Moligand™ para fluxos de trabalho cromatográficos e analíticos sensíveis que exigem interferência mínima da linha de base.

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Comprovação documental

Citado em 0 publicações revisadas por pares nas áreas de cromatografia, síntese orgânica e reações de acoplamento cruzado.

Especificações

Product Name
Gal-(K)4, Agonist of GAL 1 receptor;Agonist of GAL 2 receptor, CAS No.rp174097
Grau
Moligand™
Especificações e pureza
Moligand™
Tipo de ação
AGONIST
Mecanismo de ação
Agonist of GAL 1 receptor;Agonist of GAL 2 receptor
CAS
rp174097
Tipo de molécula
Peptide
Product Line
Produtos biológicos
Armazenamento e envio
Condições de armazenamento de armazenamento
Room temperature

Documentação

📋 Ficha de dados de segurança (FDS)

Documento abrangente sobre perigos, manuseamento, armazenamento e conformidade regulamentar.

<<<<<<< HEAD Baixar SDS → ======= Baixar SDS → >>>>>>> release248-p3

✅ Certificado de análise (COA)

Dados de qualidade específicos do lote. Introduza o número de lote para obter o COA exato.

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📊 Ficha técnica

Resumo de referência rápida das especificações e aplicações do produto.

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🔬 Folha de especificações

Atributos de qualidade completos e critérios de aceitação para este grau.

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Dados avançados

Alvos associados (humanos)
GALR1 Tchem Galanin receptor type 1 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
GALR2 Tchem Galanin receptor type 2 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
Certificados（CoA,COO,BSE/TSE e Mapa de Análise)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Informação genética
Reference
  • 1. Kinetics and inhibition of recombinant human cystathionine gamma-lyase. Toward the rational control of transsulfuration., The Journal of biological chemistry, Steegborn, C C and 7 more authors.
  • 2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences., Proceedings of the National Academy of Sciences of the United States of America, Strausberg, Robert L RL and 83 more authors.
  • 3. Genomic basis of cystathioninuria (MIM 219500) revealed by multiple mutations in cystathionine gamma-lyase (CTH)., Human genetics, Wang, Jian J and Hegele, Robert A RA.
  • 4. Cloning and nucleotide sequence of human liver cDNA encoding for cystathionine gamma-lyase., Biochemical and biophysical research communications, Lu, Y Y, O'Dowd, B F BF, Orrego, H H and Israel, Y Y.
  • 5. Single nucleotide polymorphism in CTH associated with variation in plasma homocysteine concentration., Clinical genetics, Wang, J J, Huff, A M AM, Spence, J D JD and Hegele, R A RA.
  • 6. Cystathionine gamma-lyase overexpression inhibits cell proliferation via a H2S-dependent modulation of ERK1/2 phosphorylation and p21Cip/WAK-1., The Journal of biological chemistry, Yang, Guangdong G, Cao, Kun K, Wu, Lingyun L and Wang, Rui R.
  • 7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)., Genome research, Gerhard, Daniela S DS and 115 more authors.
  • 8. Towards a proteome-scale map of the human protein-protein interaction network., Nature, Rual, Jean-François JF and 37 more authors.
  • 9. The DNA sequence and biological annotation of human chromosome 1., Nature, Gregory, S G SG and 178 more authors.
  • 10. Polymorphisms in one-carbon metabolism and trans-sulfuration pathway genes and susceptibility to bladder cancer., International journal of cancer, Moore, Lee E LE and 14 more authors. more
Calculadoras de soluções
Revisões

Avaliações dos Clientes

Application Protocols

Item-specific, validated application protocols and recommended dilutions: Not specified for this item; refer to CoA/Spec Sheet.

General guidance for solution preparation and plate-based screening (not product-specific):

  • Stock solutions: prepare 10–50 mM in DMSO or water depending on solubility; record solvent, concentration (qNMR if possible), and lot number.
  • Working concentrations: for biochemical assays, typical final concentrations span 0.1–100 µM. Maintain DMSO ≤1–2% v/v in the final well.
  • Filtration: 0.2 µm PVDF/nylon filters for organic stocks; 0.22 µm PES for aqueous stocks.
  • Stability checks: run LC–MS at T0 and post-assay to confirm integrity; store assay plates at 4 °C during use to reduce degradation.
  • Documentation: include negative vehicle controls and, where appropriate, structurally related controls to benchmark behavior.

These are generic practices for small-molecule library members and should be adapted once the specific properties of SKU rp174097 are confirmed.

Biological Roles

Item-specific biological data: Not specified for this item; refer to CoA/Spec Sheet.

General/literature context for “Gal-” multivalent ligands (not product-specific, for background only):

  • D-Galactose residues are recognized by several lectins (e.g., the hepatic asialoglycoprotein receptor, ASGPR, and certain galectins) in a stereoselective manner. Multivalent presentation can enhance avidity through clustering effects (glycocluster concept).
  • Tetra-lysine scaffolds are commonly used to create four-point displays of ligands for studying multivalency in carbohydrate–protein interactions.
  • In biochemical research, such constructs may serve as tools to probe binding specificity, kinetics, and competitive inhibition in vitro.

Caveats:

  • The presence, density, and orientation of galactose on SKU rp174097 are Not specified here; do not assume binding to any target without experimental confirmation.
  • Any biological testing should be designed with appropriate controls (vehicle, unrelated glycoconjugate, and known positive ligands) and conducted under institutional safety policies.

Research Use Only: As stated, this product is for research use only and not for use in humans or for diagnostic purposes.

Buffer Applications

This product is not a buffering reagent and no buffer capacity or recipes are provided.

  • Item-specific buffer roles, pKa, and buffering range: Not specified for this item; refer to CoA/Spec Sheet if applicable.
  • Practical note: If dissolving the compound for biochemical assays, select a buffer appropriate to the biology (e.g., PBS, HEPES, or Tris) and verify compound stability at the chosen pH and ionic strength.
  • For amine-bearing ligands, avoid buffers with primary amines (Tris) during NHS-ester coupling steps to prevent side reactions; use HEPES or phosphate instead.
Green Alternatives

Given the likely high polarity of a Gal–lysine-type ligand, greener handling typically focuses on solvent choice and workup rather than replacing the molecule itself.

Greener solvent considerations (general; not product-specific):

  • Prefer water or aqueous buffers when feasible for dissolution, purification (SEC), and assays. Adjust pH to modulate ionization of amines.
  • If an organic cosolvent is required, consider bio-based or lower-toxicity options:
    • Ethanol (renewable source, low toxicity) as a cosolvent with water.
    • Propylene carbonate or glycerol derivatives for certain processing steps (check compatibility).
  • Minimize DMSO/DMF volumes by preparing concentrated master stocks and diluting into water immediately before use.

Comparison (general):

  • DMSO vs ethanol/water: DMSO maximizes solubility but has higher environmental burden; EtOH/H2O is greener yet may give lower solubility.
  • DMF vs MeOH/H2O: DMF is effective but problematic in EHS profiles; MeOH/H2O may suffice for many weighing and transfer operations if solubility allows.

Operational greening:

  • Use microscale reaction and assay formats (96–1536-well) to reduce solvent consumption.
  • Favor membrane- or SEC-based desalting over large-volume liquid–liquid extractions.
  • Implement lyophilization instead of solvent-intensive evaporations when preparing aqueous stocks.

Note: No specific environmental metrics (E-factors, biodegradability) are available for this item; consult CoA/SDS for any item-specific statements.

Pharmaceutical Uses

No pharmacopeial status or excipient role is provided for this item.

  • Item-specific pharmaceutical/formulation uses: Not specified for this item; refer to CoA/Spec Sheet.

General context (not product-specific; no therapeutic claims):

  • Research-grade multivalent ligands are sometimes evaluated in pre-formulation studies for binding or delivery concepts. Such investigations typically remain at the in vitro/ex vivo level in academic or industrial R&D and do not imply suitability for clinical use.
  • If formulation screening is required for research assays, common approaches include preparing DMSO master stocks for dilution into isotonic buffers and assessing stability by LC–MS over time.

Compliance reminder: This product is supplied for research use only and is not intended as an active pharmaceutical ingredient (API) or excipient in human or veterinary products.

Physical Properties

Item-specific specifications (from Product Data):

  • Appearance: Not specified for this item; refer to CoA/Spec Sheet.
  • Molecular weight: Not specified for this item; refer to CoA/Spec Sheet.

Typical physical properties for galactose–lysine multivalent ligands (literature/general; NOT product specifications):

  • Physical state: often obtained as amorphous solids or foams; hygroscopicity can be moderate to high due to multiple polar groups.
  • Solubility: frequently soluble in water and polar aprotic solvents (e.g., DMSO), variably soluble in methanol/ethanol; poor solubility expected in nonpolar solvents. Exact solubility for this item is Not specified; verify experimentally.
  • pKa (qualitative): primary amines (if free) typically pKa ~9–10 (literature); amide groups are nonbasic; carbohydrate hydroxyls have pKa >12 and remain neutral in water.
  • LogP: such constructs generally exhibit very low logP (high polarity), but precise value depends on protecting groups and counter-ions.
  • Melting/decomposition: many peptidic/glycosylated materials decompose before melting; thermograms vary widely (DSC/TGA recommended). No value specified for this item.

Practical notes (general):

  • Because of likely high polarity, drying under high vacuum at ambient to 40 °C over P2O5 or KOH pellets can help reduce water content prior to microanalytical weighing.
  • If solubility is uncertain, prepare a small screen across H2O, PBS, DMSO, DMF, and 1:1 cosolvent mixtures; document clarity and stability over 24–48 h.
Quality and Grades

Item-specific information from Product Data:

  • Grade/Purity: Moligand™

Context and implications (general; not a specification):

  • Moligand™ indicates this item is supplied as part of a screening-oriented small-molecule/ligand library suitable for discovery, binding, and probe-development workflows. Such materials are typically intended for research use only, not for diagnostic or therapeutic applications.
  • Documentation: For assay-critical work, request and review the product’s CoA/Spec Sheet for identity confirmation (e.g., NMR, MS, HPLC purity), salt form, residual solvent profile, and water content if available. In the absence of listed stabilizers or additives, assume none are present unless specified.
  • Fit-for-purpose: Moligand™ items are generally prepared to enable medicinal chemistry and chemical biology screening. If low-UV absorbance or LC–MS compatibility is required, verify by obtaining chromatographic traces and UV spectra from the CoA or by in-house QC.
  • Batch-to-batch consistency: Library materials can have multiple lot numbers; for hit validation, re-order the same lot or re-qualify a new lot by orthogonal analytical methods (e.g., qNMR, HRMS, LC purity at multiple wavelengths).

Item-specific unstated parameters:

  • Stabilizers, salt/counter-ion, UV cutoff, metal content, residual peroxides, and exact purity percentage: Not specified for this item; refer to CoA/Spec Sheet.
Reaction and Applications

Manufacturer Applications (verbatim): Not specified.

General applications for Moligand™-grade small molecules/ligands (not product-specific):

  • Screening and discovery: use in biochemical or biophysical binding assays (e.g., SPR, MST, ITC) to probe interactions with lectins or other proteins if the ligand presents saccharide motifs (literature context for “Gal-” labels).
  • Chemical biology: potential use as a probe or building block for multivalent display in surface immobilization or nanoparticle conjugation to evaluate carbohydrate–protein recognition (literature).
  • Conjugation chemistry: if the construct bears amines or carboxyls, standard EDC/NHS, isothiocyanate, or NHS-ester coupling pathways can be employed to attach dyes, biotin, or linkers (verify functional groups from the CoA before use).
  • Materials and arrays: potential incorporation into glycan arrays or affinity resins for enrichment experiments (general).

Practical tips (general):

  • Characterize functional groups by NMR and MS prior to coupling. Perform a test coupling on the milligram scale to optimize pH and stoichiometry.
  • For aqueous bioconjugation, maintain pH 7.5–8.5 for NHS ester–amine couplings; quench with ethanolamine and purify by SEC or HPLC.
  • For screening assays, establish compound integrity with LC–MS pre/post-assay; track any hydrolysis of linkers or deprotection events.

Note: The exact reactivity and applications of SKU rp174097 depend on its definitive structure, which is Not specified here; consult the CoA/Spec Sheet.

Reaction Conditions

Item-specific reaction conditions: Not specified for this item; refer to CoA/Spec Sheet.

General guidance for common bioconjugation reactions relevant to amine-/carboxyl-bearing ligands (literature; not product-specific):

  • NHS ester–amine coupling: pH 7.5–8.5 in phosphate or HEPES buffer; 1.1–5.0 equiv NHS ester; 0–25 °C; 0.5–2 h; quench with ethanolamine. Monitor by LC–MS.
  • EDC/NHS activation (carboxyl to amide): MES buffer pH 5.0–6.0 for activation, then add amine at pH 7.5–8.0; 0–25 °C; 0.5–2 h. Include sulfo-NHS for aqueous compatibility.
  • Reductive amination (for aldehyde-bearing sugars; if applicable): sodium cyanoborohydride or picoline borane in aqueous MeOH, pH 6–7; 25 °C; 1–16 h. Verify that the ligand indeed contains an aldehyde before attempting.
  • Click chemistry (CuAAC; if azide/alkyne installed): CuSO4/sodium ascorbate or CuBr/ligand in H2O/t-BuOH/DMSO; 0–25 °C; 0.5–4 h.

These are literature conditions intended as starting points only. Confirm functional groups and stability for SKU rp174097 by reviewing the CoA and conducting pilot reactions.

Safety and Handling

Item-specific hazard data from Product Data:

  • GHS Classification: Not specified for this item; refer to SDS.
  • Signal Word: Not specified for this item; refer to SDS.
  • H-Statements: Not specified for this item; refer to SDS.
  • Pictograms: Not specified for this item; refer to SDS.

General laboratory safety guidance (not product-specific; defer to the official SDS for authoritative information):

  • PPE: lab coat, safety glasses, and appropriate chemical-resistant gloves (e.g., nitrile). For powders, consider handling in a fume hood or ventilated enclosure to minimize dust/aerosol exposure.
  • Incompatibilities: polyfunctional amines and carbohydrates generally show broad compatibility, but avoid strong oxidizers and strong acids/bases if labile glycosidic linkages or protecting groups are present. Avoid reactive acylating/alkylating agents unless intended.
  • Hygroscopic materials: minimize ambient exposure; cap promptly. For electrostatic powders, use antistatic measures.
  • First aid (general): in case of eye/skin contact, rinse with water for at least 15 min; if inhaled, move to fresh air; if ingested, rinse mouth. Seek medical evaluation in all exposure cases and provide the SDS.
  • Fire safety: many organic solids are combustible; use CO2, dry chemical, or foam. Thermal decomposition may produce nitrogen oxides and carbon oxides.

Always consult the product-specific SDS and CoA/Spec Sheet for definitive hazard classification, handling, and disposal guidance.

Solvent Selection

Item-specific solubility: Not specified for this item; verify experimentally and consult the CoA/Spec Sheet.

General guidance for peptide-/glycan-like multivalent ligands (literature; not product-specific):

  • Likely polarity class: highly polar, hydrogen-bond donor/acceptor-rich.
  • Primary solvents to attempt: water, buffer (e.g., PBS, pH 7.4), DMSO, DMF. If free amines are present, acidic aqueous media (e.g., 0.1% TFA in water) can increase solubility; for salt formation, add stoichiometric HCl in MeOH/H2O.
  • Secondary options: mixture cosolvents (H2O:DMSO 9:1 to 1:1), aqueous ethanol or isopropanol for intermediate polarity materials.
  • Poor choices (typically): nonpolar hydrocarbons and chlorinated solvents.

Small comparison (general):

  • Water: biologically relevant, green; may require pH adjustment for amine-rich species.
  • DMSO: excellent solvating power; compatible with screening plates; limit final assay concentration to ≤1–2% v/v in biological assays to reduce vehicle effects.
  • DMF: strong solvent for weighing stocks; moisture-sensitive equipment recommended; consider toxicity and disposal.
  • MeOH/EtOH: can assist in lyophilization and stock preparation; check stability of glycosidic linkages under acidic alcohol conditions.

Practical tips:

  • Prepare a 10–50 mM DMSO master stock when water solubility is uncertain; dilute into aqueous media just-in-time.
  • Filter 0.2 µm if solutions appear hazy; record pH and ionic strength to improve reproducibility.
Storage and Reconstitution

Item-specific storage and shipping:

  • Storage Conditions: Room temperature (per Product Data).
  • Shipped In: Not specified for this item; refer to CoA/Spec Sheet.

General storage guidance for small-molecule/ligand library members (not product-specific):

  • Protect from moisture and light until properties are known. Store in tightly closed containers within a desiccator or dry cabinet, especially if hygroscopic.
  • For long-term archiving, consider aliquoting into crimped vials or caps with PTFE liners; flush headspace with dry nitrogen/argon if oxidation is a concern.

Reconstitution (general):

  • Select solvent based on solubility: water, buffer (PBS/HEPES), or DMSO. Begin with a small test dissolution (1–2 mg/mL) to confirm clarity and stability.
  • If forming aqueous stocks, consider preparing the hydrochloride salt in situ for amine-rich compounds by adding a slight stoichiometric excess of HCl (aq or MeOH·HCl), then lyophilize and redissolve.
  • Filter sterilize (0.22 µm) only if required by the application and if the compound is stable to the membrane material.
  • Avoid repeated freeze–thaw cycles; prepare single-use aliquots. Record preparation date, solvent, and concentration on the label.

Always defer to the product’s CoA/Spec Sheet and SDS for item-specific instructions and stability data.

Structure and Identity

Item-specific identifiers from Product Data:

  • SKU: rp174097
  • Product Name: Gal-(K)4
  • CAS: rp174097 (internal catalog identifier; not a registered CAS number)
  • Grade: Moligand™
  • Molecular formula: Not specified for this item; refer to CoA/Spec Sheet.
  • Molecular weight: Not specified for this item; refer to CoA/Spec Sheet.
  • SMILES: Not specified for this item; refer to CoA/Spec Sheet.
  • InChIKey: Not specified for this item; refer to CoA/Spec Sheet.

Structural description (general/literature context; verify against CoA for this SKU):

  • The designation “Gal-(K)4” is commonly used in literature to denote a multivalent scaffold that displays galactose (Gal) on a tetra-lysine (K4) core or dendron. Such constructs often feature a central lysine branching motif (e.g., Lys2–Lys2) to create four terminal amines that can be functionalized with galactosyl units.
  • Typical functional groups in these families (literature) include: carbohydrate hemiacetals/acetal linkages (if protected), amide bonds from lysine coupling, and multiple primary amines or their amide/urea derivatives depending on protection and conjugation chemistry.
  • Stereochemistry (literature): D-galactose residues are stereochemically defined at multiple centers; lysine side chains contain a primary ε-amine. Overall construct may be a mixture of protecting-group states depending on synthesis.

Important: The exact connectivity, protecting groups, counter-ions, and degree of substitution for Aladdin SKU rp174097 are not specified here. Consult the product CoA/Spec Sheet for the definitive structure and analytical identifiers of this item.

Synthetic Utility

Item-specific functional groups and reactivity: Not specified for this item; refer to CoA/Spec Sheet.

General utility for galactose-bearing, lysine-based multivalent scaffolds (literature; not product-specific):

  • As building blocks: multivalent amine-terminated scaffolds can be acylated, carbamylated, or clicked (e.g., azide–alkyne cycloaddition) when appropriately functionalized to construct higher-order glycoclusters, polymer conjugates, or surfaces.
  • Protecting-group strategy: orthogonal protection on lysine (Boc/Fmoc on α/ε-amines) enables stepwise diversification; carbohydrate protecting groups (e.g., acetyl, benzyl) control solubility/reactivity during synthesis.
  • Conjugation handles: if the item presents free amines, NHS ester chemistry is straightforward; if carboxylates are present, EDC/NHS activation allows coupling to amines on carriers.
  • Analytical control: qNMR, MALDI-TOF/ESI-MS, and HPLC at multiple wavelengths (210–220, 254 nm) help confirm substitution level and purity in iterative syntheses.

Caveat: The precise functional group complement for SKU rp174097 is not provided here; all synthetic plans should be validated by examining the product’s CoA and, if needed, conducting preliminary test reactions on a small scale.

Target Specificity

Item-specific target information (antigen/epitope/protein, species reactivity, clone, isotype): Not applicable and not specified for this small-molecule/ligand product.

General note (background; not product-specific):

  • If the construct presents galactose motifs, potential interactions with galactose-recognizing lectins may be explored experimentally. However, no target specificity is provided or implied for this SKU.

Perguntas frequentes

What is Moligand??
Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.
How should this product be stored?
Store at room temperature.
What are the CAS number, molecular formula and molecular weight?
The CAS Number is rp174097.
What documentation is provided?
Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.

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