Gastrodin - Moligand™,10mM in DMSO , CAS No.62499-27-8

CAS: 62499-27-8 Cat. No.: G408719 Fórmula: C₁₃H₁₈O₇ Peso molecular: 286.28 Número CE: 683-202-7

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

Gastrodine | β-D-Glucopyranoside, 4-(hydroxymethyl)phenyl

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Visão geral

Information

Gastrodin (Gastrodine), an anti-inflammatory polyphenol extracted from Chinese natural herbal Gastrodia elata Blume., benefits neurodegenerative diseases.
In vitro

Gastrodin is the most important and effective ingredient extracted from Chinese natural herbal Gastrodia elata. Gastrodin (30, 40, and 60 mM) significantly attenuates levels of neurotoxic proinflammatory mediators and proinflammatory cytokines by inhibition of the NF-kappaB signaling pathway and phosphorylation of MAPKs in LPS-stimulated microglial cells. However, It also upregulates the phosphatidylinositol 3-kinase (PI3-K)/Akt signaling, resulting in the inhibitory effects NF-kappaB and MAPKs activation in H9c2 cardiomyocytes.

In vivo

Gastrodin at 5 mg/kg can improve cycloheximide- and apomorphine-induced amnesia, but not scopolamine-induced acquisition impairment in rats. Thus, GAS can facilitate memory consolidation and retrieval, but not acquisition. LD50: Mice >1000mg/kg (i.v.)
Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Sinónimos

Gastrodine | β-D-Glucopyranoside, 4-(hydroxymethyl)phenyl

Especificações e pureza

Moligand™,10mM in DMSO

Mecanismos bioquímicos e fisiológicos

Gastrodin (Gastrodine), an anti-inflammatory polyphenol extracted from Chinese natural herbal Gastrodia elata Blume., benefits neurodegenerative diseases.

Condições de armazenamento de armazenamento

Store at -80°C

Enviado em

Dry ice packs + Cold packs

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Grau

Moligand™

Tipo de ação

INHIBITOR

Nomes e identificadores

SMILES isoméricas

C1=CC(=CC=C1CO)O[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)O)O

Peso molecular

286.28

Reaxy-Rn

25441801

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=25441801&ln=

Propriedades químicas e físicas

• Rotação específica [α]: -66.0 to -70.0 deg(C=1,H2O)
• Ponto de fusão (°C): 154-155°C