Granisetron - Moligand™, 10mM in DMSO , Antagonist of 5-HT 3A, CAS No.109889-09-0, Antagonist of 5-HT 3A

CAS: 109889-09-0 Cat. No.: G420578 Fórmula: C18H24N4O Peso molecular: 312.41 Número CE: 686-533-5
Disponível para encomenda
GRADE & PURITY Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10mM in DMSO
Synonyms
Sustol | UNII-WZG3J2MCOL | CHEBI:5537 | Z1501485362 | 1-Methyl-N-(9-methyl-endo-9-azabicyclo(3.3.1)non-3-yl)-1H-indazole-3-carboxamide | Granisetron (AB-1001) | GRANISETRON [MI] | LY-278584 | Q-101870 | DTXSID0023111 | NCGC00388522-02 | Sancuso | BRL-4369
Storage
Store at -80°C
Shipped In
Dry ice packs + Cold packs
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Size
Alemanha (EU)
USA*
Price
Qty
1ml
G420578-1ml
—
1 Em stock

41,56€

60,65€
Gravar 19,09 € (31.47%)
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Why this grade

Moligand™, 10mM in DMSO Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Visão geral

Granisetron is a serotonin 5-HT3 receptor antagonist used as an antiemetic to treat nausea and vomiting following chemotherapy.

Specifications

Sinónimos
Sustol | UNII-WZG3J2MCOL | CHEBI:5537 | Z1501485362 | 1-Methyl-N-(9-methyl-endo-9-azabicyclo(3.3.1)non-3-yl)-1H-indazole-3-carboxamide | Granisetron (AB-1001) | GRANISETRON [MI] | LY-278584 | Q-101870 | DTXSID0023111 | NCGC00388522-02 | Sancuso | BRL-4369
Especificações e pureza
Moligand™, 10mM in DMSO
Mecanismos bioquímicos e fisiológicos

Description:
IC50 Value: 17uM (GR reduced 5-HT-evoked contractions) [1]
Granisetron is a serotonin 5-HT3 receptor antagonist used as an antiemetic to treat nausea and vomiting following chemotherapy.
in vitro: In rat forest

Condições de armazenamento de armazenamento
Store at -80°C
Enviado em
Dry ice packs + Cold packs
Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.
Grau
Moligand™
Tipo de ação
ANTAGONIST
Mecanismo de ação
Antagonist of 5-HT 3A
Nomes e identificadores
Pubchem Sid
Sorrisos canónicos
CN1C2CCCC1CC(C2)NC(=O)C3=NN(C4=CC=CC=C43)C
IUPAC Name
1-methyl-N-[(1R,5S)-9-methyl-9-azabicyclo[3.3.1]nonan-3-yl]indazole-3-carboxamide
InChIKey
MFWNKCLOYSRHCJ-AGUYFDCRSA-N
INCHI
1S/C18H24N4O/c1-21-13-6-5-7-14(21)11-12(10-13)19-18(23)17-15-8-3-4-9-16(15)22(2)20-17/h3-4,8-9,12-14H,5-7,10-11H2,1-2H3,(H,19,23)/t12?,13-,14+
SMILES isoméricas
CN1[C@@H]2CCC[C@H]1CC(C2)NC(=O)C3=NN(C4=CC=CC=C43)C
Peso molecular
312.41
Reaxy-Rn
6660726
Reaxys-RN_link_address
https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=6660726&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Estrutura 3D
Modelo de Estrutura Química Interativa





Alvos associados (humanos)
HTR3B Tchem 5-hydroxytryptamine receptor 3B (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
HTR3A Tclin 5-hydroxytryptamine receptor 3A (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
KCNH2 Tclin Potassium voltage-gated channel subfamily H member 2 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
Certificados(CoA,COO,BSE/TSE e Mapa de Análise)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Propriedades químicas e físicas
Peso molecular312.400 g/mol
XLogP32.800
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count2
Exact Mass312.195 Da
Monoisotopic Mass312.195 Da
Topological Polar Surface Area50.200 Ų
Heavy Atom Count23
Formal Charge0
Complexity442.000
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count1
Calculadoras de soluções
Revisões

Avaliações dos Clientes

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