GSK2643943A - ≥98% , CAS No.2449301-27-1

CAS: 2449301-27-1 Cat. No.: G413665 Fórmula: C₁₇H₁₂FN₃ Peso molecular: 277.3

GRADE & PURITY ≥98%

Synonyms

1H-​Indole-​3-​carbonitrile,2-​amino-​6-​[2-​(3-​fluorophenyl)​ethenyl]​-

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Visão geral

Information

GSK2643943A is an inhibitor ofdeubiquitylating enzyme (DUB)with IC50 of 160 nM forUSP20/Ub-Rho.

Targets

USP20/Ub-Rho (Cell-free assay) 160 nM

Specifications

Sinónimos

1H-​Indole-​3-​carbonitrile,2-​amino-​6-​[2-​(3-​fluorophenyl)​ethenyl]​-

Especificações e pureza

≥98%

Mecanismos bioquímicos e fisiológicos

GSK2643943A is an inhibitor of deubiquitylating enzyme (DUB) with IC50 of 160 nM for USP20/Ub-Rho.

Condições de armazenamento de armazenamento

Store at -20°C

Enviado em

Ice chest + Ice pads

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Tipo de ação

INHIBITOR

Pureza

≥98%

Propriedades do produto

ALogP

3.571

Contagem HBD

2

Ligação rotativa

2

Nomes e identificadores

Pubchem Sid

504773490

Pubchem Sid Url

https://pubchem.ncbi.nlm.nih.gov/substance/504773490

Sorrisos canónicos

C1=CC(=CC(=C1)F)C=CC2=CC3=C(C=C2)C(=C(N3)N)C#N

IUPAC Name

2-amino-6-[(E)-2-(3-fluorophenyl)ethenyl]-1H-indole-3-carbonitrile

InChIKey

CGXBPMZRTMXEIA-SNAWJCMRSA-N

INCHI

1S/C17H12FN3/c18-13-3-1-2-11(8-13)4-5-12-6-7-14-15(10-19)17(20)21-16(14)9-12/h1-9,21H,20H2/b5-4+

Peso molecular

277.3

Reaxy-Rn

38910864

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=38910864&ln=

Propriedades químicas e físicas

• Solubilidade: Solubility (25°C) In vitro DMSO: 55 mg/mL (198.34 mM); Ethanol: 8 mg/mL (28.84 mM); Water: Insoluble
• DMSO (mg/mL) Solubilidade máxima: 55
• DMSO (mM) Solubilidade máxima: 198.341146772449
• Água (mg/mL) Solubilidade máxima: ＜1
• Peso molecular: 277.290 g/mol
• XLogP3: 4.300
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 277.102 Da
• Monoisotopic Mass: 277.102 Da
• Topological Polar Surface Area: 65.600 Ų
• Heavy Atom Count: 21
• Formal Charge: 0
• Complexity: 441.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 1
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 1
• Covalently-Bonded Unit Count: 1

Perguntas frequentes

What is the purity of this product?

This product is supplied at ≥98% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2449301-27-1, the molecular formula is C17H12FN3, and the molecular weight is 277.3 g/mol. InChIKey CGXBPMZRTMXEIA-SNAWJCMRSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.