GW438014A - ≥99% , CAS No.469861-49-2

CAS: 469861-49-2 Cat. No.: G648232 Fórmula: C₂₂H₁₉N₃O Peso molecular: 341.4 Número CE: 806-243-6 PubChem CID: 6918627

GRADE & PURITY ≥99%

Synonyms

GW438014A | GW-438014A | GW-438014-A | N-[1-(2-Phenylethyl)-1H-benzimidazol-2-yl]benzamide | GW 438014 A | N-[1-(2-phenylethyl)benzimidazol-2-yl]benzamide | GW 438014A | NCGC00387447-01

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Visão geral

GW438014A is a potent and selective NPY-Y5 receptor antagonist. GW438014A inhibits food intake and reduces body weight gain in obese rodents.

In Vivo

GW438014A (10 mg/kg; i.p.; daily, for 7 d) inhibits spontaneous as well as overnight fasting-induced and NPY-induced feeding in rats and in food-deprived genetically obese ob/ob mice . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: obese ob/ob mice Dosage: 10 mg/kg Administration: intraperitoneal injection; daily, for 7 d Result: Decreased the rate of weight gain in both lean and obese rats.

Form:Solid

Specifications

Sinónimos

GW438014A | GW-438014A | GW-438014-A | N-[1-(2-Phenylethyl)-1H-benzimidazol-2-yl]benzamide | GW 438014 A | N-[1-(2-phenylethyl)benzimidazol-2-yl]benzamide | GW 438014A | NCGC00387447-01

Especificações e pureza

≥99%

Mecanismos bioquímicos e fisiológicos

GW438014A is a potent and selective NPY-Y5 receptor antagonist. GW438014A inhibits food intake and reduces body weight gain in obese rodents.

Condições de armazenamento de armazenamento

Store at -20°C

Enviado em

Ice chest + Ice pads

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Tipo de ação

ANTAGONIST

Pureza

≥99%

Nomes e identificadores

• Sorrisos canónicos: C1=CC=C(C=C1)CCN2C3=CC=CC=C3N=C2NC(=O)C4=CC=CC=C4
• IUPAC Name: N-[1-(2-phenylethyl)benzimidazol-2-yl]benzamide
• InChIKey: CDUDZZGLFOFINU-UHFFFAOYSA-N
• INCHI: 1S/C22H19N3O/c26-21(18-11-5-2-6-12-18)24-22-23-19-13-7-8-14-20(19)25(22)16-15-17-9-3-1-4-10-17/h1-14H,15-16H2,(H,23,24,26)
• SMILES isoméricas: C1=CC=C(C=C1)CCN2C3=CC=CC=C3N=C2NC(=O)C4=CC=CC=C4
• WGK Alemanha: 3
• PubChem CID: 6918627
• Peso molecular: 341.4

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Classe Benzimidazoles

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Classe: Benzimidazoles
• Subclass: Not available
• Intermediate Tree Nodes: Not available
• Direct Parent: Benzimidazoles
• Alternative Parents: Benzamides Benzoyl derivatives N-substituted imidazoles Heteroaromatic compounds Secondary carboxylic acid amides Azacyclic compounds Organooxygen compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Benzamide - Benzimidazole - Benzoic acid or derivatives - Benzoyl - Monocyclic benzene moiety - N-substituted imidazole - Benzenoid - Azole - Imidazole - Heteroaromatic compound - Secondary carboxylic acid amide - Carboxamide group - Carboxylic acid derivative - Azacycle - Organooxygen compound - Organonitrogen compound - Hydrocarbon derivative - Organic oxide - Organic oxygen compound - Organic nitrogen compound - Aromatic heteropolycyclic compound
• Descrição: This compound belongs to the class of organic compounds known as benzimidazoles. These are organic compounds containing a benzene ring fused to an imidazole ring (five member ring containing a nitrogen atom, 4 carbon atoms, and two double bonds).
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Propriedades químicas e físicas

• Solubilidade: DMSO : 250 mg/mL (571.42 mM; Need ultrasonic)
• Peso molecular: 341.400 g/mol
• XLogP3: 4.500
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 5
• Exact Mass: 341.153 Da
• Monoisotopic Mass: 341.153 Da
• Topological Polar Surface Area: 46.900 Ų
• Heavy Atom Count: 26
• Formal Charge: 0
• Complexity: 456.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Perguntas frequentes

What is the purity of this product?

This product is supplied at ≥99% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 469861-49-2, the molecular formula is C22H19N3O, and the molecular weight is 341.4 g/mol. InChIKey CDUDZZGLFOFINU-UHFFFAOYSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.