HaloPROTAC-E , CAS No.2365478-58-4

CAS: 2365478-58-4 Cat. No.: H651187 Fórmula: C₃₉H₅₆ClN₅O₈S Peso molecular: 790.4 PubChem CID: 154723985

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Application

PROTAC

Visão geral

HaloPROTAC-E is a novel HaloPROTAC potent degrader, inducing reversible degradation of two endosomally localized proteins, SGK3 and VPS34 , with a DC 50 of 3-10 nM, remarkably selective inducing only degradation of the Halo tagged endogenous VPS34 complex (VPS34, VPS15, Beclin1 , and ATG14).

Form:Oil

Especificações

Mecanismos bioquímicos e fisiológicos

HaloPROTAC-E is a novel HaloPROTAC potent degrader, inducing reversible degradation of two endosomally localized proteins, SGK3 and VPS34 , with a DC 50 of 3-10 nM, remarkably selective inducing only degradation of the Halo tagged endogenous VPS34 complex

Condições de armazenamento de armazenamento

Store at -20°C

Enviado em

Ice chest + Ice pads

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Tipo de ação

INHIBITOR

Nomes e identificadores

Sorrisos canónicos

CC1=C(SC=N1)C2=CC(=C(C=C2)CNC(=O)C3CC(CN3C(=O)C(C(C)(C)C)NC(=O)C4(CC4)C#N)O)OCCOCCOCCOCCCCCCCl

IUPAC Name

(2S,4R)-N-[[2-[2-[2-[2-(6-chlorohexoxy)ethoxy]ethoxy]ethoxy]-4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-1-[(2S)-2-[(1-cyanocyclopropanecarbonyl)amino]-3,3-dimethylbutanoyl]-4-hydroxypyrrolidine-2-carboxamide

InChIKey

NJCGXLMTZGCSRS-JSWXEYCZSA-N

INCHI

1S/C39H56ClN5O8S/c1-27-33(54-26-43-27)28-9-10-29(32(21-28)53-20-19-52-18-17-51-16-15-50-14-8-6-5-7-13-40)23-42-35(47)31-22-30(46)24-45(31)36(48)34(38(2,3)4)44-37(49)39(25-41)11-12-39/h9-10,21,26,30-31,34,46H,5-8,11-20,22-24H2,1-4H3,(H,42,47)(H,44,49)/t30-,31+,34-/m1/s1

PubChem CID

154723985

Peso molecular

790.4

Propriedades químicas e físicas

• Solubilidade: DMSO : 100 mg/mL (126.52 mM; Need ultrasonic)

Perguntas frequentes

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2365478-58-4, the molecular formula is C39H56ClN5O8S, and the molecular weight is 790.4 g/mol. InChIKey NJCGXLMTZGCSRS-JSWXEYCZSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.