HS024 TFA, Antagonist of MC 1 receptor;Antagonist of MC 3 receptor;Antagonist of MC 4 receptor;Antagonist of MC 5 receptor, CAS No.212370-59-7(free base), Antagonist of MC 1 receptor;Antagonist of MC 3 receptor;Antagonist of MC 4 receptor;Antagonist of MC 5 receptor

CAS: 212370-59-7(free base) Cat. No.: H288535 Fórmula: C₅₈H₇₉N₁₉O₁₀S₂(free base) Peso molecular: 1266.50(free base)

GRAU & PUREZA Moligand™, ≥95%

Especificações

Product Name

HS024 TFA, Antagonist of MC 1 receptor;Antagonist of MC 3 receptor;Antagonist of MC 4 receptor;Antagonist of MC 5 receptor, CAS No.212370-59-7(free base)

Sinónimos

AKOS024456803 | HS 024 | N-Acetyl-L-cysteinyl-L-norleucyl-L-arginyl-L-histidyl-3-(2-naphthalenyl)-D-alanyl-L-arginyl-L-tryptophylglycyl-L-cysteinamide cyclic (1->9)disulfide | HS024 | DTXSID301034918 | Long Name (Added to Synonym)

Grau

Moligand™

Especificações e pureza

Moligand™, ≥95%

Mecanismos bioquímicos e fisiológicos

Highly potent melanocortin MC4receptor antagonist (Kivalues are 0.29, 18.6, 5.45 and 3.29 nM for cloned human MC4, MC1, MC3and MC5receptors respectively). Increases food intake, and blocksα-MSH- and MTII-induced hypotension and bradycardia in rats, follow

Sequência

CXRHXRWGC(Modifications: Cys-1 = N-terminal Ac, X-2 = Nle, X-5 = Nal, Cys-9 = C-terminal amide, Disulfide bridge between 1 - 9)

Tipo de ação

ANTAGONIST

Mecanismo de ação

Antagonist of MC 1 receptor;Antagonist of MC 3 receptor;Antagonist of MC 4 receptor;Antagonist of MC 5 receptor

CAS

212370-59-7(free base)

Tipo de molécula

Peptide

Armazenamento e envio

Condições de armazenamento de armazenamento

Store at -20°C,Desiccated

Enviado em

Ice chest + Ice pads

Alvos associados (humanos)

MC5R Tchem Melanocortin receptor 5 (0 Activities)

Discover Target: MC5R

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MC4R Tclin Melanocortin receptor 4 (0 Activities)

Discover Target: MC4R

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MC3R Tchem Melanocortin receptor 3 (0 Activities)

Discover Target: MC3R

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MC1R Tclin Melanocyte-stimulating hormone receptor (0 Activities)

Discover Target: MC1R

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Informação genética

• Alternate Names: AKOS024456803 | HS 024 | N-Acetyl-L-cysteinyl-L-norleucyl-L-arginyl-L-histidyl-3-(2-naphthalenyl)-D-alanyl-L-arginyl-L-tryptophylglycyl-L-cysteinamide cyclic (1->9)disulfide | HS024 | DTXSID301034918 | Long Name (Added to Synonym)
• Reference:
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  • 51. Decreased cystathionine-γ-lyase (CSE) activity in livers of type 1 diabetic rats and peripheral blood mononuclear cells (PBMC) of type 1 diabetic patients., The Journal of biological chemistry, Manna, Prasenjit P, Gungor, Neslihan N, McVie, Robert R and Jain, Sushil K SK.
  • 52. Hydrogen sulfide (H2S)/cystathionine γ-lyase (CSE) pathway contributes to the proliferation of hepatoma cells., Mutation research, Pan, Yan Y and 5 more authors.
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Perguntas frequentes

What is the purity of this product?

This product is supplied at ≥95% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How should this product be stored?

Store at ?20 °C, desiccated. Keep the container tightly closed with desiccant — the material is moisture-sensitive.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 212370-59-7(free base).

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.