Hydralazine HCl - ≥99% , CAS No.304-20-1

CAS: 304-20-1 Cat. No.: H129281 Fórmula: C₈H₈N₄·HCl Peso molecular: 196.64 Número CE: 206-151-0

GRAU & PUREZA ≥99%

Synonyms

HYDRALAZINE HYDROCHLORIDE (USP MONOGRAPH)|Hydrochloride, Hydralazine|1-Hydrazinophthalazine hydrochloride|Apresoline|HYDRALAZINE HYDROCHLORIDE (USP IMPURITY)|Pharmakon1600-01500334|Hydralazini hydrochloridum|Hyperex|Hydralazine hydrochloride (USP:JAN)|HYDROSERPINE PLUS (R-H-H) COMPONENT HYDRALAZINE HYDROCHLORIDE|Praparat 5968|SER-A-GEN COMPONENT HYDRALAZINE HYDROCHLORIDE|(Z)-1-Hydrazono-1,2-dihydrophthalazine hydrochloride|Apresine|Apresoline (TN)|HYDRALAZINE HYDROCHLORIDE [USP MONOGRAPH]|HYDRALAZINE HYDROCHLORIDE|HYDRALAZINE HYDROCHLORIDE [USP IMPURITY]|1-hydrazinophthalazine HCL|Apresoline-esidrix|HYDRALAZINE HCL|Lopress|Hydralazine chloride|Hydralazinehydrochloride|HYDRALAZINE HYDROCHLORIDE (USP-RS)|HYDRALAZINE HYDROCHLORIDE [MART.]|Phthalazine, monohydrochloride|SERPASIL-APRESOLINE COMPONENT HYDRALAZINE HYDROCHLORIDE|1(2H)-Phthalazinone, hydrochloride|Aiselazine|Hydralazine-15N4Hydrochloride|Phthalazine, 1-hydrazinyl-, hydrochloride (1:1)|1(2H)-Phthalazinone hydrazone hydrochloride|Apresoline hydrochloride|Hyperazin|Phthalazinone, monohydrochloride|Rolazine|1(2H)-Phthalazinone, monohydrochloride|1(2H)-Phthalazinone, hydrazone, hydrochloride|HYDRALAZINE HYDROCHLORIDE [USP-RS]|SER-AP-ES COMPONENT HYDRALAZINE HYDROCHLORIDE|Hydralazine monohydrochloride|1-hydrazinophthalazinemonohydrochloride|Apressinum|CAM-AP-ES COMPONENT HYDRALAZINE HYDROCHLORIDE|Hydralazine hydrochloride [USP:JAN]|1(2H)-Phthalazinone, hydrazone, monohydrochloride|HYDRA-ZIDE COMPONENT HYDRALAZINE HYDROCHLORIDE|HYDRAP-ES COMPONENT HYDRALAZINE HYDROCHLORIDE|Phthalazinone hydrazone monohydrochloride|Nor-press 25|Phthalazine, 1-hydrazino-, monohydrochloride|APRESAZIDE COMPONENT HYDRALAZINE HYDROCHLORIDE|Hydralazine hydrochloride (JP17/USP)|Hydralazine hydrochloride [JAN]|Hydralazinhydrochlorid|APRESSINUM [WHO-IP]|1-Hydrazinophthalazine monohydrochloride|BPI-103|1-Hydrazinylphthalazine hydrochloride|BIDIL COMPONENT HYDRALAZINE HYDROCHLORIDE|HYDRALAZINE HYDROCHLORIDE (MART.)|Slow-Apresolin|Hydralazine (hydrochloride)|Phthalazinone, hydrazone, monohydrochloride|UNIPRES COMPONENT HYDRALAZINE HYDROCHLORIDE|APRESOLINE-ESIDRIX COMPONENT HYDRALAZINE HYDROCHLORIDE|DRALSERP COMPONENT HYDRALAZINE HYDROCHLORIDE

Storage

Room temperature

Shipped In

Normal

Visão geral

Hydralazine HCl is a hydrochloride salt of hydralazine (Apresoline) that is a direct-acting smooth muscle relaxant with an IC50 of 1.9 mM.
An inhibitor of Dnmt, MAO-A/B, and amine oxidase.

Especificações

Sinónimos

HYDRALAZINE HYDROCHLORIDE (USP MONOGRAPH) | Hydrochloride, Hydralazine | 1-Hydrazinophthalazine hydrochloride | Apresoline | HYDRALAZINE HYDROCHLORIDE (USP IMPURITY) | Pharmakon1600-01500334 | Hydralazini hydrochloridum | Hyperex | Hydralazine hydrochloride (USP:JAN) | HYDROSERPINE PLUS (R-H-H) COMPONENT HYDRALAZINE HYDROCHLORIDE | Prapar Show more

Especificações e pureza

≥99%

Mecanismos bioquímicos e fisiológicos

1-Hydrazinophthalazine Hydrochloride is a DNA methyltransferase (Dnmt) inhibitor which modulates epigenetic regulation of gene expression. 1-Hydrazinophthalazine Hydrochloride also acts as a non-selective MAO-A/B inhibitor and semicarbazide sensitive amin

Condições de armazenamento de armazenamento

Room temperature

Enviado em

Normal

Nota

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Toxic, refer to SDS for further information. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Pureza

≥99%

Nomes e identificadores

Pubchem Sid

504751825

Pubchem Sid Url

https://pubchem.ncbi.nlm.nih.gov/substance/504751825

Sorrisos canónicos

C1=CC=C2C(=C1)C=NN=C2NN.Cl

IUPAC Name

phthalazin-1-ylhydrazine;hydrochloride

InChIKey

ZUXNZUWOTSUBMN-UHFFFAOYSA-N

INCHI

1S/C8H8N4.ClH/c9-11-8-7-4-2-1-3-6(7)5-10-12-8;/h1-5H,9H2,(H,11,12);1H

SMILES isoméricas

C1=CC=C2C(=C1)C=NN=C2NN.Cl

WGK Alemanha

3

RTECS

TH9000000

Peso molecular

196.64

Reaxy-Rn

3568329

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=3568329&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Classe Diazanaphthalenes
      • Subclass Benzodiazines

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Classe: Diazanaphthalenes
• Subclass: Benzodiazines
• Intermediate Tree Nodes: Not available
• Direct Parent: Phthalazines
• Alternative Parents: Pyridazines and derivatives Imidolactams Benzenoids Heteroaromatic compounds Azacyclic compounds Organopnictogen compounds Hydrochlorides Hydrocarbon derivatives Hydrazines and derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Phthalazine - Imidolactam - Benzenoid - Pyridazine - Heteroaromatic compound - Azacycle - Organic nitrogen compound - Organopnictogen compound - Hydrocarbon derivative - Hydrochloride - Organonitrogen compound - Hydrazine derivative - Aromatic heteropolycyclic compound
• Descrição: This compound belongs to the class of organic compounds known as phthalazines. These are compounds containing a phthalazine moiety, which consists of a benzene ring fused to a pyridazine, forming a 2,3-benzodiazine skeleton.
• External Descriptors: hydrochloride

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Alvos associados (humanos)

CYP1A2 Tchem Cytochrome P450 1A2 (0 Activities)

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MPO Tchem Myeloperoxidase (0 Activities)

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ACHE Tclin Acetylcholinesterase (18204 Activities)

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KCNH2 Tclin HERG (29587 Activities)

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MDH1 Tchem Malate dehydrogenase cytoplasmic (119 Activities)

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NR1I2 Tchem Pregnane X receptor (6667 Activities)

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CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)

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TP53 Tchem Cellular tumor antigen p53 (48468 Activities)

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Homo sapiens (32628 Activities)

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MCF7 (126967 Activities)

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MDA-MB-468 (9477 Activities)

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HEK293 (82097 Activities)

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APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase (38016 Activities)

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TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)

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KDM4E Tchem Lysine-specific demethylase 4D-like (40243 Activities)

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SMN1 Tchem Survival motor neuron protein (34246 Activities)

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BLM Tchem Bloom syndrome protein (4248 Activities)

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PMP22 Tbio Peripheral myelin protein 22 (699 Activities)

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SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (2672 Activities)

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SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (2517 Activities)

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GOT1 Tbio Aspartate aminotransferase, cytoplasmic (118 Activities)

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OGG1 Tchem N-glycosylase/DNA lyase (81 Activities)

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NTHL1 Tbio Endonuclease III-like protein 1 (51 Activities)

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Alvos associados (não humanos)

Plasmodium falciparum (966862 Activities)

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Cavia porcellus (23802 Activities)

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Mus musculus (284745 Activities)

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Rattus norvegicus (775804 Activities)

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rep Replicase polyprotein 1ab (378 Activities)

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BCHE Cholinesterase (8742 Activities)

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Mapt Microtubule-associated protein tau (6 Activities)

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Rorc Nuclear receptor ROR-gamma (89407 Activities)

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fba Putative fructose-1,6-bisphosphate aldolase (15559 Activities)

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Nr1i2 Nuclear receptor subfamily 1 group I member 2 (14 Activities)

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Gabrp GABA-A receptor; anion channel (5731 Activities)

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SARS-CoV-2 (38078 Activities)

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mutM Formamidopyrimidine-DNA glycosylase (36 Activities)

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Mecanismos de ação

Propriedades químicas e físicas

• Solubilidade: DMSO Water 1 mg/mL Ethanol
• Ponto de fusão (°C): 273°C(dec.)(lit.)
• Peso molecular: 196.640 g/mol
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 196.052 Da
• Monoisotopic Mass: 196.052 Da
• Topological Polar Surface Area: 63.800 Ų
• Heavy Atom Count: 13
• Formal Charge: 0
• Complexity: 150.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 2

XLogP3