IMD-0560 - 10mM in Ethanol , CAS No.439144-66-8

CAS: 439144-66-8 Cat. No.: I654919 Fórmula: C₁₅H₈BrF₆NO₂ Peso molecular: 428.12 PubChem CID: 11464503

GRADE & PURITY 10mM in Ethanol

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Visão geral

IMD-0560 is a novel IκB kinase β inhibitor.

In Vitro

Pretreatment with IMD-0560 inhibits both IκBα degradation and p65 phosphorylation induced by TNFα. IMD-0560 also suppresses TNFα-induced transcriptional activity. Pretreatment with IMD-0560 strongly inhibits TNFα-induced cell invasion. Pretreatment with IMD-0560 suppresses MMP-9 activity by inhibiting MMP-9 expression. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

The tumor size is reduced in the IMD-0560-treated groups in a dose-dependent manner, and no tumor is detected in some mice treated with 5 mg/kg IMD-0560. Zygoma destruction is significantly suppressed in the IMD-0560-treated groups compare to the control groups. Although the tumor size in the 5 mg/kg IMD-0560-treated group is smaller than that of the 3 mg/kg IMD-0560-treated group, the inhibitory effect of each treatment on zygoma destruction is similar . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:IKKβ

Specifications

Especificações e pureza

10mM in Ethanol

Mecanismos bioquímicos e fisiológicos

IMD-0560 is a novel IκB kinase β inhibitor.

Condições de armazenamento de armazenamento

Store at -80°C

Enviado em

Dry ice packs + Cold packs

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Nomes e identificadores

• SMILES isoméricas: C1=CC(=C(C=C1C(F)(F)F)NC(=O)C2=C(C=CC(=C2)Br)O)C(F)(F)F
• CAS alternativo: 439144-66-8
• PubChem CID: 11464503
• Termos de entrada MeSH: IMD-0560;N-(2,5-bis(trifluoromethyl)phenyl)-5-bromo-2-hydroxybenzamide
• Peso molecular: 428.12

Perguntas frequentes

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 439144-66-8, the molecular formula is C15H8BrF6NO2, and the molecular weight is 428.12 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.