JHU395 - 10mM in DMSO , CAS No.2079938-92-2

CAS: 2079938-92-2 Cat. No.: J422523 Fórmula: C₂₂H₂₉N₃O₇ Peso molecular: 447.48 PubChem CID: 126555751

GRADE & PURITY 10mM in DMSO

Synonyms

L-​Norleucine,6-​diazo-​N-​[[(2,​2-​dimethyl-​1-​oxopropoxy)​phenylmethoxy]​carbonyl]​-​5-​oxo-​,1-​methylethyl ester

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Visão geral

Information

JHU395 JHU395 is a novel orally bioavailable GA (glutamine antagonists) prodrug designed to circulate inert in plasma, but permeate and release active GA within target tissues. JHU395 delivers active GA to malignant peripheral nerve sheath tumor (MPNST), and significantly inhibits tumor growth without observed toxicity.

Targets

Glutamine

In vitro

JHU395 inhibits growth of multiple biosynthetic processes by tumors (MPNST) cells, while growth of immortalized Schwann cells is minimally affected. JHU395 induces less PARP cleavage as a marker of apoptosis in human MPNST cells. JHU395 is a plasma stable lipophilic GA prodrug which delivers DON to MPNST in an in vitro plasma to tumor cell partitioning assay measurement.

In vivo

orally administered JHU395 delivers active GA to tumors with over twofold higher tumor-to-plasma exposure, and significantly inhibits tumor growth in a murine flank MPNST model without observed toxicity.

Cell Research(from reference)

Cell lines：sNF96.2, sNF02.2, ipn02.32 

Concentrations：10 μM, 20μM 

Incubation Time：1 h, 24 h 

Specifications

Sinónimos

L-​Norleucine,6-​diazo-​N-​[[(2,​2-​dimethyl-​1-​oxopropoxy)​phenylmethoxy]​carbonyl]​-​5-​oxo-​,1-​methylethyl ester

Especificações e pureza

10mM in DMSO

Mecanismos bioquímicos e fisiológicos

JHU395 is a novel orally bioavailable GA (glutamine antagonists) prodrug designed to circulate inert in plasma, but permeate and release active GA within target tissues. JHU395 delivers active GA to malignant peripheral nerve sheath tumor (MPNST), and sig

Condições de armazenamento de armazenamento

Store at -80°C

Enviado em

Dry ice packs + Cold packs

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Propriedades do produto

ALogP

4.148

Contagem HBD

1

Ligação rotativa

14

Nomes e identificadores

Sorrisos canónicos

CC(C)OC(=O)C(CCC(=O)C=[N+]=N)NC(=O)OC(C1=CC=CC=C1)OC(=O)C(C)(C)C

IUPAC Name

[(5S)-5-[[2,2-dimethylpropanoyloxy(phenyl)methoxy]carbonylamino]-2,6-dioxo-6-propan-2-yloxyhexylidene]-iminoazanium

InChIKey

KCTDLEPDMHFLHZ-KKFHFHRHSA-O

INCHI

1S/C22H29N3O7/c1-14(2)30-18(27)17(12-11-16(26)13-24-23)25-21(29)32-19(15-9-7-6-8-10-15)31-20(28)22(3,4)5/h6-10,13-14,17,19,23H,11-12H2,1-5H3/p+1/t17-,19?/m0/s1

PubChem CID

126555751

Peso molecular

447.48

Perguntas frequentes

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2079938-92-2, the molecular formula is C22H29N3O7, and the molecular weight is 447.48 g/mol. InChIKey KCTDLEPDMHFLHZ-KKFHFHRHSA-O.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.