JNJ-1013 - ≥99% , CAS No.2597343-08-1

CAS: 2597343-08-1 Cat. No.: J647610 Fórmula: C₄₆H₅₅N₉O₇S Peso molecular: 878.05

GRADE & PURITY ≥99%

Storage

Protected from light,Store at -80°C

Shipped In

Dry ice packs + Cold packs

Application

PROTAC

Visão geral

JNJ-1013 is a potent and selective IRAK1 degrader with an IC 50 s of 72, 443, 1071 nM for IRAK1 , IRAK4 , VHL FP respectively. JNJ-1013 induces Apoptosis and increases the expression of cleavaged PARP . JNJ-1013 decreases the expression IRAK1 , p-IKBα, pSTAT3(Tyr705)

In Vitro

JNJ-1013 (Degrader-3; 1.5-10000 nM; 24 h) dose-dependently degrades IRAK1 protein with an DC 50 value of 3 nM.. JNJ-1013 (1 µM) decreased the expression of MG-132 stiyumed IRAK1 in a dose-dependent manner. JNJ-1013 (0.01, 0.03, 0.1, 0.3, 1 µM; 24 h) decreases the expression IRAK1, p-IKBα, pSTAT3(Tyr705) and increases the expression of cleavaged PARP. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: HEK293T cells Concentration: 1.5-10000 nM Incubation Time: 24 h Result: Decreased the expression of IRAK1 in a dose-dependent manner.

Form:Solid

IC50& Target:IRAK1 72 nM (IC 50 ) IRAK4 443 nM (IC 50 ) VHL FP 1071 nM (IC 50 )

Specifications

Especificações e pureza

≥99%

Mecanismos bioquímicos e fisiológicos

JNJ-1013 is a potent and selective IRAK1 degrader with an IC 50 s of 72, 443, 1071 nM for IRAK1 , IRAK4 , VHL FP respectively. JNJ-1013 induces Apoptosis and increases the expression of cleavaged PARP . JNJ-1013 decreases the expression IRAK1 , p-IKBα, pS

Condições de armazenamento de armazenamento

Protected from light,Store at -80°C

Enviado em

Dry ice packs + Cold packs

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Tipo de ação

DEGRADER

Pureza

≥99%

Nomes e identificadores

• Peso molecular: 878.05

Propriedades químicas e físicas

• Solubilidade: DMSO : 25 mg/mL (28.47 mM; ultrasonic and warming and heat to 60°C)

Perguntas frequentes

What is the purity of this product?

This product is supplied at ≥99% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?80 °C, protected from light. The material is light-sensitive — keep it in its original opaque or amber container.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2597343-08-1, the molecular formula is C46H55N9O7S, and the molecular weight is 878.05 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.