KN-93 - Moligand™, 10mM in DMSO , Inhibitor of calcium/calmodulin-dependent protein kinase II alpha subunit, CAS No.139298-40-1, Inhibitor of calcium/calmodulin-dependent protein kinase II alpha subunit

CAS: 139298-40-1 Cat. No.: K421478 Fórmula: C₂₆H₂₉ClN₂O₄S Peso molecular: 599.03

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

AMY3402 | (2-[N -(2-hydroxyethyl)]-N -(4-methoxybenzenesulfonyl)]amino-N -(4-chlorocinnamyl)-N -methylbenzylamine) | AKOS015994570 | BCP9000817 | J-007263 | NCGC00162399-02 | SCHEMBL14569460 | N-[2-({[(2E)-3-(4-chlorophenyl)prop-2-en-1-yl](methyl)amino}me

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Visão geral

KN-93 is a selective inhibitor of Ca2+/calmodulin-dependent kinase II (CaMKII), competitively blocking CaM binding to the kinase (Ki = 370 nM).
An effective inhibitor of CaMKII phosphorylating activity

Specifications

Sinónimos

AMY3402 | (2-[N -(2-hydroxyethyl)]-N -(4-methoxybenzenesulfonyl)]amino-N -(4-chlorocinnamyl)-N -methylbenzylamine) | AKOS015994570 | BCP9000817 | J-007263 | NCGC00162399-02 | SCHEMBL14569460 | N-[2-({[(2E)-3-(4-chlorophenyl)prop-2-en-1-yl](methyl)amino}me

Especificações e pureza

Moligand™, 10mM in DMSO

Mecanismos bioquímicos e fisiológicos

KN-93 is a selective inhibitor of Ca2+/calmodulin-dependent kinase II (CaMKII), competitively blocking CaM binding to the kinase (Ki = 370 nM). KN-93 inhibits histamine-induced aminopyrine uptake in parietal cells (IC50 = 300 nM). KN-93 has been used to i

Condições de armazenamento de armazenamento

Store at -80°C

Enviado em

Dry ice packs + Cold packs

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Grau

Moligand™

Tipo de ação

INHIBITOR

Mecanismo de ação

Inhibitor of calcium/calmodulin-dependent protein kinase II alpha subunit

Nomes e identificadores

• SMILES isoméricas: CN(C/C=C/C1=CC=C(C=C1)Cl)CC2=CC=CC=C2N(CCO)S(=O)(=O)C3=CC=C(C=C3)OC
• WGK Alemanha: 3
• Peso molecular: 599.03
• Reaxy-Rn: 8357363
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=8357363&ln=

Alvos associados (humanos)

CAMK2A Tchem Calcium/calmodulin-dependent protein kinase type II subunit alpha (1 Activities)

Discover Target: CAMK2A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Propriedades químicas e físicas

• Sensibilidade: Heat Sensitive
• Índice de refração: 1.63
• Ponto de ebulição (°C): 657.60° C at 760 mmHg

Referências

1. Jinpeng Lv, Ximei Zhang, Xiaohong An, Yan Cao, Duo Meng, Kun Zou, Rongyin Gao, Ruzhi Zhang.  (2023)  The inhibition of VDAC1 oligomerization promotes pigmentation through the CaMK–CRTCs/CREB–MITF pathway.  EXPERIMENTAL CELL RESEARCH,      [PMID:38070860] [10.1016/j.yexcr.2023.113874]

2. Yuqian Chen, Jin Liu, Qianqian Zhang, Limin Chai, Huan Chen, Danyang Li, Yan Wang, Yuanjie Qiu, Nirui Shen, Jia Zhang, Qingting Wang, Jian Wang, Xinming Xie, Shaojun Li, Manxiang Li.  (2024)  Activation of CaMKII/HDAC4 by SDF1 contributes to pulmonary arterial hypertension via stabilization Runx2.  EUROPEAN JOURNAL OF PHARMACOLOGY,      [PMID:38479721] [10.1016/j.ejphar.2024.176483]