Koumine - 10mM in DMSO , CAS No.1358-76-5

CAS: 1358-76-5 Cat. No.: K421364 Fórmula: C₂₀H₂₂N₂O Peso molecular: 306.4 Número CE: 111-893-2

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Visão geral

Koumine can induce apoptosis of LoVo cells in a time-dependent manner and inhibit the DNA synthesis in LoVo cells, thereby blocking the cell cycle from G1 to S phase. Koumine has a significant analgesic effect in rodent behavioral models of inflammatory and neuropathic pain, and that the reduction in neuropathic pain may be associated with the upregulation of allopregnanolone in the spinal cord. Koumine has therapeutic effect against psoriasis, which is related to the inhibition of epidermal cell proliferation, promoting the formation of granular cells and decreasing the serum level of IL- Koumine can significantly reduce the damage to axon and myelin sheath of the sciatic nerve and increase sensory nerve conduction velocity , without affecting body weight and blood glucose, these findings encourage the use of koumine in the treatment of diabetic neuropathy. Koumine has antineoplastic effect, may be a future breast cancer chemotherapeutic agent. Koumine may produce anxiolytic-effect by increasing the levels of pregnenolone and allopregnenolone in hippocampus.

Specifications

Especificações e pureza

10mM in DMSO

Condições de armazenamento de armazenamento

Store at -80°C

Enviado em

Dry ice packs + Cold packs

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Tipo de ação

ACTIVATOR

Propriedades do produto

• ALogP: 1.879
• hba_count: 2
• Ligação rotativa: 1

Nomes e identificadores

• Pubchem Sid: 528765089
• Sorrisos canónicos: CN1CC2(C3CC4C5=NC6=CC=CC=C6C52CC1C3CO4)C=C
• IUPAC Name: (1R,10R,12S,15S,16R,17S)-15-ethenyl-13-methyl-19-oxa-3,13-diazahexacyclo[14.3.1.02,10.04,9.010,15.012,17]icosa-2,4,6,8-tetraene
• InChIKey: VTLYEMHGPMGUOT-FXWNUWCSSA-N
• INCHI: 1S/C20H22N2O/c1-3-19-11-22(2)16-9-20(19)13-6-4-5-7-15(13)21-18(20)17-8-14(19)12(16)10-23-17/h3-7,12,14,16-17H,1,8-11H2,2H3/t12-,14+,16-,17+,19-,20+/m0/s1
• SMILES isoméricas: CN1C[C@]2([C@@H]3C[C@@H]4C5=NC6=CC=CC=C6[C@]52C[C@H]1[C@H]3CO4)C=C
• Peso molecular: 306.4
• Reaxy-Rn: 25328208
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=25328208&ln=

Propriedades químicas e físicas

• DMSO (mg/mL) Solubilidade máxima: 15
• DMSO (mM) Solubilidade máxima: 48.9553771084918