KYN-101 - ≥98% , CAS No.2247950-73-6

CAS: 2247950-73-6 Cat. No.: K649692 Fórmula: C₂₂H₁₉FN₆ Peso molecular: 386.42

GRADE & PURITY ≥98%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Visão geral

KYN-101 is a potent, selective and orally active AHR inhibitor. KYN-101 decreases the CYP1A1 mRNA expression. KYN-101 shows anti-cancer activity.

In Vitro

KYN-101 (0.5, 1 µM; 24 h) decreases the CYP1A1 mRNA expression in IDO high samples. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

KYN-101 (10 mg/kg; p.o.; daily for 12 days) shows anti-cancer activity in mice . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: 6-8 weeks, C57BL/6J mice (B16IDO tumor-bearing mice) Dosage: 10 mg/kg Administration: P.o.; daily for 12 days Result: Reduced tumor growth in B16IDO tumor-bearing mice and combination of KYN-101 and anti-PD-1 led to improved tumor growth delay and extended survival in CT26 models.

Form:Solid

Specifications

Especificações e pureza

≥98%

Mecanismos bioquímicos e fisiológicos

KYN-101 is a potent, selective and orally active AHR inhibitor. KYN-101 decreases the CYP1A1 mRNA expression. KYN-101 shows anti-cancer activity.

Condições de armazenamento de armazenamento

Store at -20°C

Enviado em

Ice chest + Ice pads

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Tipo de ação

INHIBITOR

Pureza

≥98%

Nomes e identificadores

• Peso molecular: 386.42

Referências

1. Yvhao Xie, Xinxin Li, Qingshi Meng, Jinjun Li, Xin Wang, Liying Zhu, Weiwei Wang, Xiaoqiong Li.  (2024)  Interplay between gut microbiota and tryptophan metabolism in type 2 diabetic mice treated with metformin.  Microbiology Spectrum,      [PMID:39162538] [10.1128/spectrum.00291-24]

Perguntas frequentes

What is the purity of this product?

This product is supplied at ≥98% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2247950-73-6, the molecular formula is C22H19FN6, and the molecular weight is 386.42 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.